Publicações


2014201320122011 | 2010

  • 2015

Afonso MB, Rodrigues PM, Carvalho T, Caridade M, Borralho P, Cortez-Pinto H, Castro RE, Rodrigues CMP. Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis. Clinical Science. 2015;129(8);721-39.

Brito H, Martins AC, Lavrado J, Mendes E, Francisco AP, Santos SA, Ohnmacht SA, Kim NS, Rodrigues CMP, Moreira R, Neidle S, Borralho PM, Paulo A. Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo 3,2-b quinoline Tri-Alkylamine Derivatives. Plos One. 2015;10(5).

Dionisio PA, Amaral JD, Ribeiro MF, Lo AC, D’Hooge R, Rodrigues CMP. Amyloid-beta pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset. Neurobiology of Aging. 2015;36(1);228-40.

Florindo PR, Pereira DM, Borralho PM, Rodrigues CMP, Piedade MFM, Fernandes AC. Cyclopentadienyl-Ruthenium(II) and Iron(II) Organometallic Compounds with Carbohydrate Derivative Ligands as Good Colorectal Anticancer Agents. Journal of Medicinal Chemistry. 2015;58(10);4339-47.

Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, Lopez-Otin C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Munoz-Pinedo C, Nunez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Berghe TV, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation. 2015;22(1);58-73.

Morgado AL, Xavier JM, Dionisio PA, Ribeiro MFC, Dias RB, Sebastiao AM, Sola S, Rodrigues CMP. MicroRNA-34a Modulates Neural Stem Cell Differentiation by Regulating Expression of Synaptic and Autophagic Proteins. Molecular Neurobiology. 2015;51(3);1168-83.

Moutinho M, Nunes MJ, Gomes AQ, Gama MJ, Cedazo-Minguez A, Rodrigues CMP, Bjorkhem I, Rodrigues E. Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells. Molecular Neurobiology. 2015;51(3);1489-503.

Paterna A, Borralho PM, Gomes SE, Mulhovo S, Rodrigues CMP, Ferreira MJU. Monoterpene indole alkaloid hydrazone derivatives with apoptosis inducing activity in human HCT116 colon and HepG2 liver carcinoma cells. Bioorganic & Medicinal Chemistry Letters. 2015;25(17);3556-9.

Preusse K, Tveriakhina L, Schuster-Gossler K, Gaspar C, Rosa AI, Henrique D, Gossler A, Stauber M. Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo. Plos Genetics. 2015;11(6).

Rodrigues PM, Afonso MB, Simao AL, Borralho PM, Rodrigues CMP, Castro RE. Inhibition of NF-kappa B by deoxycholic acid induces miR-21/PDCD4-dependent hepatocelular apoptosis. Scientific Reports. 2015;5(

Santos LA, Sola S, Rodrigues CMP, Rebelo-de-Andrade H. Distinct kinetics and pathways of apoptosis in influenza A and B virus infection. Virus Research. 2015;205(33-40.

Simoes AES, Pereira DM, Gomes SE, Brito H, Carvalho T, French A, Castro RE, Steer CJ, Thibodeau SN, Rodrigues CMP, Borralho PM. Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-kappa B activation. Cell Death & Disease. 2015;6(

Sousa T, Castro RE, Pinto SN, Coutinho A, Lucas SD, Moreira R, Rodrigues CMP, Prieto M, Fernandes F. Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties. Journal of Lipid Research. 2015;56(11);2158-71.

Lavrado, Joao; Brito, Hugo; Borralho, Pedro M; et al. KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines. Scientific reports Volume: 5 Pages: 9696 Published: 2015

Borralho PM; Steer CJ, Rodrigues CMP. Isolation of mitochondria from liver and extraction of total RNA and protein: analyses of micriRNA and prtein expressions. Methods in Molecylar Biology 2015; 1241: 9-22.

Cascalheira JF, Goncalves M, Barroso M, Castro R, Palmeira M, Serpa A, Dias-Cabral AC, Domingues FC, Almeida S. Association of the transcobalamin II gene 776C -> G polymorphism with Alzheimer’s type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A -> C polymorphism genotype. Annals of Clinical Biochemistry. 2015;52(4);448-55.

Coelho AI, Lourenco S, Trabuco M, Silva MJ, Oliveira A, Gaspar A, Diogo L, de Almeida IT, Vicente JB, Rivera I. Functional correction by antisense therapy of a splicing mutation in the GALT gene. European Journal of Human Genetics. 2015;23(4);500-6.

Madeira A, Mosca AF, Moura TF, Soveral G. Aquaporin-5 Is Expressed in Adipocytes with Implications in Adipose Differentiation. Iubmb Life. 2015;67(1);54-60.

Madeira A, Moura TF, Soveral G. Aquaglyceroporins: implications in adipose biology and obesity. Cellular and Molecular Life Sciences. 2015;72(4);759-71.

Martins SV, Madeira A, Lopes PA, Pires VMR, Alfaia CM, Prates JAM, Moura T, Soveral G. Adipocyte membrane glycerol permeability is involved in the anti-adipogenic effect of conjugated linoleic acid. Biochemical and Biophysical Research Communications. 2015;458(2);356-61.

Matos JE, Marques CC, Moura TF, Baptista MC, Horta AEM, Soveral G, Pereira RMLN. Conjugated linoleic acid improves oocyte cryosurvival through modulation of the cryoprotectants influx rate. Reproductive Biology and Endocrinology. 2015;13(

Molina-Hidalgo FJ, Medina-Puche L, Gelis S, Ramos J, Sabir F, Soveral G, Prista C, Iglesias-Fernandez R, Caballero JL, Munoz-Blanco J, Blanco-Portales R. Functional characterization of FaNIP1;1 gene, a ripening-related and receptacle-specific aquaporin in strawberry fruit. Plant Science. 2015;238(198-211.

Rodriguez A, Moreno NR, Balaguer I, Mendez-Gimenez L, Becerril S, Catalan V, Gomez-Ambrosi J, Portincasa P, Calamita G, Soveral G, Malagon MM, Fruehbeck G. Leptin administration restores the altered adipose and hepatic expression of aquaglyceroporins improving the non-alcoholic fatty liver of ob/ob mice. Scientific Reports. 2015;5(

Sperl W, Fleuren L, Freisinger P, Haack TB, Ribes A, Feichtinger RG, Rodenburg RJ, Zimmermann FA, Koch J, Rivera I, Prokisch H, Smeitink JA, Mayr JA. The spectrum of pyruvate oxidation defects in the diagnosis of mitochondrial disorders. Journal of Inherited Metabolic Disease. 2015;38(3);391-403.

Wamelink MMC, Ramos RJJF, van den Elzen APM, Ruijter GJG, Bonte R, Diogo L, Garcia P, Neves N, Nota B, Haschemi A, de Almeida IT, Salomons GS. First two unrelated cases of isolated sedoheptulokinase deficiency: A benign disorder? Journal of Inherited Metabolic Disease. 2015;38(5);889-94.

Singh J, Sabir F, Sangwan RS, Narnoliya LK, Saxena S, Sangwan NS. Enhanced secondary metabolite production and pathway gene expression by leaf explants-induced direct root morphotypes are regulated by combination of growth regulators and culture conditions in Centella asiatica (L.) urban. Plant Growth Regulation. 2015;75(1);55-66.

Mendes MI, Smith DE, Vicente JB, Tavares De Almeida I, Ben-Omran T, Salomons GS, Rivera IA, Leandro P, Blom HJ. Small aminothiol compounds improve the function of Arg to Cys variant proteins: effect on the human cystathionine β-synthase p.R336C. Hum Mol Genet. 2015 Dec 20;24(25):7339-48.

Rocha J, Eduardo-Figueira M, Barateiro A, Fernandes A, Brites D, Bronze R, Duarte CMM, Serra AT, Pinto R, Freitas M, Fernandes E, Silva-Lima B, Mota-Filipe H, Sepodes B. Anti-inflammatory Effect of Rosmarinic Acid and an Extract of Rosmarinus officinalis in Rat Models of Local and Systemic Inflammation. Basic & Clinical Pharmacology & Toxicology. 2015;116(5);398-413.

Brites D, Fernandes A. Bilirubin-induced neural impairment: A special focus on myelination, age-related windows of susceptibility and associated co-morbidities. Seminars in Fetal & Neonatal Medicine. 2015;20(1);14-9.

Rocha J, Eduardo-Figueira M, Barateiro A, Fernandes A, Brites D, Pinto R, Freitas M, Fernandes E, Mota-Filipe H, Sepodes B. Erythropoietin Reduces Acute Lung Injury and Multiple Organ Failure/Dysfunction Associated to a Scald-Burn Inflammatory Injury in the Rat. Inflammation. 2015;38(1);312-26.

Janota CS, Brites D, Lemere CA, Brito MA. Glio-vascular changes during ageing in wild-type and Alzheimer’s disease-like APP/PS1 mice. Brain Research. 2015;1620(153-68.

Vaz AR, Cunha C, Gomes C, Schmucki N, Barbosa M, Brites D. Glycoursodeoxycholic Acid Reduces Matrix Metalloproteinase-9 and Caspase-9 Activation in a Cellular Model of Superoxide Dismutase-1 Neurodegeneration. Molecular Neurobiology. 2015;51(3);864-77.

Palmela I, Correia L, Silva RFM, Sasaki H, Kim KS, Brites D, Brito MA. Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study. Frontiers in Neuroscience. 2015;9(

Rocha J, Figueira M-E, Barateiro A, Fernandes A, Brites D, Pinto R, Freitas M, Fernandes E, Mota-Filipe H, Sepodes B. Inhibition of glycogen synthase kinase-3 beta attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat. Shock. 2015;43(4);369-78.

Brites D, Fernandes A. Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation. Frontiers in Cellular Neuroscience. 2015;9(

Vila-Real H, Coelho H, Rocha J, Fernandes A, Rita Ventura M, Maycock CD, Iranzo O, Simplicio AL. Peptidomimetic beta-Secretase Inhibitors Comprising a Sequence of Amyloid-beta Peptide for Alzheimer’s Disease. Journal of Medicinal Chemistry. 2015;58(14);5408-18.

Silva S, Sepodes B, Rocha J, Direito R, Fernandes A, Brites D, Freitas M, Fernandes E, Bronze MR, Figueira ME. Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis. Journal of Nutritional Biochemistry. 2015;26(4);360-8.

Zeng W, Pirzgalska RM, Pereira MMA, Kubasova N, Barateiro A, Seixas E, Lu Y-H, Kozlova A, Voss H, Martins GG, Friedman JM, Domingos AI. Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis. Cell. 2015;163(1);84-94.

Cardoso FL, Herz J, Fernandes A, Rocha J, Sepodes B, Brito MA, McGavern DB, Brites D. Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects. Journal of Neuroinflammation. 2015;12(82.

 

Barateiro A, Domingues HS, Fernandes A, Relvas JB, Brites D. Rat Cerebellar Slice Cultures Exposed to Bilirubin Evidence Reactive Gliosis, Excitotoxicity and Impaired Myelinogenesis that Is Prevented by AMPA and TNF-alpha Inhibitors. Molecular Neurobiology. 2014;49(1);424-39.

Barateiro A, Fernandes A. Temporal oligodendrocyte lineage progression: In vitro models of proliferation, differentiation and myelination. Biochimica Et Biophysica Acta-Molecular Cell Research. 2014;1843(9);1917-29.

Brites D, Vaz AR. Microglia centered pathogenesis in ALS: insights in cell interconnectivity. Frontiers in Cellular Neuroscience. 2014;8; 117

Brito MA, Palmela I, Cardoso FL, Sa-Pereira I, Brites D. Blood-Brain Barrier and Bilirubin: Clinical Aspects and Experimental Data. Archives of Medical Research. 2014;45(8);660-76.

Caldeira C, Oliveira AF, Cunha C, Vaz AR, Falcao AS, Fernandes A, Brites D. Microglia change from a reactive to an age-like phenotype with the time in culture. Frontiers in Cellular Neuroscience. 2014;8; 152

Carvalho AN, Lim JL, Nijland PG, Witte ME, Van Horssen J. Glutathione in multiple sclerosis: More than just an antioxidant? Multiple Sclerosis Journal. 2014;20(11);1425-31.

Falcao AS, Silva RFM, Vaz AR, Gomes C, Fernandes A, Barateiro A, Tiribelli C, Brites D. Cross-Talk Between Neurons and Astrocytes in Response to Bilirubin: Adverse Secondary Impacts. Neurotoxicity Research. 2014;26(1);1-15.

Fernandes A, Miller-Fleming L, Pais TF. Microglia and inflammation: conspiracy, controversy or control? Cellular and Molecular Life Sciences. 2014;71(20);3969-85.

Ferreira DMS, Afonso MB, Rodrigues PM, Simao AL, Pereira DM, Borralho PM, Rodrigues CMP, Castro RE. c-Jun N-Terminal Kinase 1/c-Jun Activation of the p53/MicroRNA 34a/Sirtuin 1 Pathway Contributes to Apoptosis Induced by Deoxycholic Acid in Rat Liver. Molecular and Cellular Biology. 2014;34(6);1100-20.

Ferreira DMS, Simao AL, Rodrigues CMP, Castro RE. Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease. Febs Journal. 2014;281(11);2503-24.

Figueira ME, Camara MB, Direito R, Rocha J, Serra AT, Duarte CMM, Fernandes A, Freitas M, Fernandes E, Marques MC, Bronze MR, Sepodes B. Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis. Food & Function. 2014;5(12);3241-51.

Luis DV, Silva J, Tomaz AI, de Almeida RFM, Larguinho M, Baptista PV, Martins LMDRS, Silva TFS, Borralho PM, Rodrigues CMP, Rodrigues AS, Pombeiro AJL, Fernandes AR. Insights into the mechanisms underlying the antiproliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies. Journal of Biological Inorganic Chemistry. 2014;19(6);787-803.

Mansoor TA, Borralho PM, Luo X, Mulhovo S, Rodrigues CMP, Ferreira M-JU. 6-Acetonyldihydrochelerythrine Is a Potent Inducer of Apoptosis in HCT116 and SW620 Colon Cancer Cells. Journal of Natural Products. 2014;77(8);1825-30.

Ratilal BO, Coutinho Arroja MM, Fidalgo Rocha JP, Afonso Fernandes AM, Barateiro AP, Tuna Oliveira Brites DM, Amaro Pinto RM, Nogueira Sepodes BM, Mota-Filipe HD. Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion. Journal of Neurosurgery. 2014;121(1);55-62.

Ribeiro CJA, Amaral JD, Rodrigues CMP, Moreira R, Santos MMM. Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents. Bioorganic & Medicinal Chemistry. 2014;22(1);577-84.

Torrado EF, Gomes C, Santos G, Fernandes A, Brites D, Falcao AS. Directing mouse embryonic neurosphere differentiation toward an enriched neuronal population. International Journal of Developmental Neuroscience. 2014;37(94-9).

Xavier JM, Morgado AL, Rodrigues CMP, Sola S. Tauroursodeoxycholic acid increases neural stem cell pool and neuronal conversion by regulating mitochondria-cell cycle retrograde signaling. Cell Cycle. 2014;13(22);3576-89.

 

Amaral JD, Herrera F, Rodrigues PM, Dionísio PA, Outeiro TF, Rodrigues CMP. Live-cell imaging of p53 interactions using a novel Venus-based bimolecular fluorescence complementation system. Biochem. Pharmacol. 2013; 85: 745-752.

Barateiro A, Domingues HS, Fernandes A, Relvas JB, Brites D. Rat Cerebellar Slice Cultures Exposed to Bilirubin Evidence Reactive Gliosis, Excitotoxicity and Impaired Myelinogenesis that Is Prevented by AMPA and TNF-α Inhibitors. Mol. Neurobiol. 2013  [Epub ahead of print] PubMed PMID: 23982745.

Barateiro A, Miron VE, Santos SD, Relvas JB, Fernandes A, Ffrench-Constant C, Brites D. Unconjugated bilirubin restricts oligodendrocyte differentiation and axonal myelination. Mol. Neurobiol. 2013; 47: 632-44.

Castro RE, Ferreira DM, Afonso MB, Borralho PM, Machado MV, Cortez-Pinto H, Rodrigues CMP. miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. J. Hepatol. 2013; 58: 119-125.

Coelho AI, Ramos R, Gaspar A, Costa C, Oliveira A, Diogo L, Garcia P, Paiva S, Martins E, Teles EL, Rodrigues E, Cardoso MT, Ferreira E, Sequeira S, Leite M, Silva MJ, de Almeida IT, Vicente JB, Rivera I. A frequent splicing mutation and novel missense mutations color the updated mutational spectrum of classic galactosemia in Portugal. J. Inher. Metab. Dis. 2013; [Epub ahead of print]

de Almeida A, Oliveira BL, Correia JDG, Soveral G, Casini A. Emerging protein targets for metal-based pharmaceutical agents: an update. Coordination Chemistry Reviews, 2013; 257: 2689-2704.

Dosa PI, Ward T, Castro RE, Rodrigues CMP, Steer CJ. Synthesis and evaluation of water-soluble prodrugs of ursodeoxycholic acid (UDCA), an anti-apoptotic bile acid. Chem. Med. Chem. 2013; 8: 1002-1011.

Esse R, Florindo C, Imbard A, Rocha MS, de Vriese AS, Smulders YM, Teerlink T, Tavares de Almeida I, Castro R, Blom HJ. Global protein and histone arginine methylation are affected in a tissue-specific manner in a rat model of diet-induced hyperhomocysteinemia. Biochim. Biophys. Acta. 2013; 1832: 1708-14.

Esse R, Rocha MS, Barroso M, Florindo C, Teerlink T, Kok RM, Smulders YM, Rivera I, Leandro P, Koolwijk P, Castro R, Blom HJ, de Almeida IT. Protein arginine methylation is more prone to inhibition by S-adenosylhomocysteine than DNA methylation in vascular endothelial cells. PLoS One 2013; 8: e55483.

Estudante M, Maya M, Morais JAG, Soveral G, Benet LZ. Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil. Molecular Pharmaceutics 2013; in press.

Falcão AS, Silva RF, Vaz AR, Silva SL, Fernandes A, Brites D. Cross-talk between neurons and astrocytes in response to bilirubin: early beneficial effects. Neurochem. Res. 2013; 38: 644-59.

Fonseca MB, Solá S, Xavier JM, Dionísio PA, Rodrigues CMP. Amyloid β peptides promote autophagy-dependent differentiation of mouse neural stem cells: Aβ-mediated neural differentiation. Mol. Neurobiol. 2013. [Epub ahead of print].

Gaspar JM, Martins A, Cruz R, Rodrigues CMP, Ambrósio AF, Santiago AR. Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose. Neuroscience. 2013;

Lavrado J, Borralho PM, Ohnmacht SA, Castro RE, Rodrigues CMP, Moreira R, Santos DJ, Neidle S, Paulo A. Synthesis, G-Quadruplex stabilisation, docking studies, and effect on cancer cells of indolo [3,2-b]quinolines with one, two, or three basic side chains. Chem. Med. Chem. 2013

Lo AC, Callaerts-Vegh Z, Nunes AF, Rodrigues CMP, D’Hooge R. Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice. Neurobiol. Dis. 2013; 50: 21-29.

Mansoor TA, Borralho PM, Dewanjee S, Mulhovo S, Rodrigues CMP, Ferreira MJ. Monoterpene bisindole alkaloids, from the African medicinal plant Tabernaemontana elegans, induce apoptosis in HCT116 human colon carcinoma cells. J. Ethnopharmacol. 2013; 149: 463-470.

Mansoor TA, Borralho PM, Luo X, Mulhovo S, Rodrigues CMP, Ferreira MJ. Apoptosis inducing activity of benzophenanthridine-type alkaloids and 2-arylbenzofuran neolignans in HCT116 colon carcinoma cells. Phytomedicine. 2013; 20: 923-929.

Mariano C, Palmela I, Pereira P, Fernandes A, Falcão AS, Cardoso FL, Vaz AR, Campos AR, Gonçalves-Ferreira A, Kim KS, Brites D, Brito MA. Tricellulin expression in brain endothelial and neural cells. Cell Tissue Res. 2013; 351: 397-407.

Martins AP, Ciancetta A, de Almeida A, Marrone A, Re N, Soveral G, Casini A. Aquaporin inhibition by gold(III) compounds: new insights. ChemMedChem. 2013; 8: 1086-1092.

Mello-Vieira J, Sousa T, Coutinho A, Fedorov A, Lucas SD, Moreira R, Castro RE, Rodrigues CMP, Prieto M, Fernandes F. Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations. Biochim. Biophys. Acta. 2013; 1828: 2152-63.

Mendes MI, Colaço HG, Smith DE, Ramos RJ, Pop A, van Dooren SJ, Tavares de Almeida I, Kluijtmans LA, Janssen MC, Rivera I, Salomons GS, Leandro P, Blom HJ. Reduced response of Cystathionine Beta-Synthase (CBS) to S-Adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in Homocystinuria patients. J. Inher. Metab. Dis 2013; [Epub ahead of print].

Nunes MJ, Moutinho M, Gama MJ, Rodrigues CMP, Rodrigues E. Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux. PLoS One. 2013; 8: e53394.

Pereira DM, Rodrigues PM, Borralho PM, Rodrigues CMP. Delivering the promise of miRNA cancer therapeutics. Drug Discov. Today. 2013; 18: 282-289.

Pinton S, Sampaio TB, Ramalho RM, Rodrigues CMP, Nogueira CW. p,p’-Methoxyl-diphenyl diselenide prevents neurodegeneration and glial cell activation induced by streptozotocin in rats. J. Alzheimers. Dis. 2013; 33: 133-144.

Ramalho RM, Nunes AF, Dias RB, Amaral JD, Lo AC, D’Hooge R, Sebastião AM, Rodrigues CMP. Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice. Neurobiol. Aging. 2013; 34: 551-561.

Santos DM, Santos MM, Moreira R, Solá S, Rodrigues CMP. Synthetic condensed 1,4-naphthoquinone derivative shifts neural stem cell differentiation by regulating redox state. Mol. Neurobiol. 2013; 47: 313-324.

Silva A, Luís D, Santos S, Silva J, Mendo AS, Coito L, Silva TF, da Silva MF, Martins LM, Pombeiro AJ, Borralho PM, Rodrigues CMP, Cabral MG, Videira PA, Monteiro C, Fernandes AR. Biological characterization of the antiproliferative potential of Co(II) and Sn(IV) coordination compounds in human cancer cell lines: a comparative proteomic approach. Drug. Metabol. Drug Interact. 2013; 28: 167-176.

Simões AE, Pereira DM, Amaral JD, Nunes AF, Gomes SE, Rodrigues PM, Lo AC, D’Hooge R, Steer CJ, Thibodeau SN, Borralho PM, Rodrigues CMP. Efficient recovery of proteins from multiple source samples after TRIzol(®) or TRIzol(®)LS RNA extraction and long-term storage. BMC Genomics. 2013; 14: 181.

Solá S, Morgado AL, Rodrigues CMP. Death receptors and mitochondria: two prime triggers of neural apoptosis and differentiation. Biochim. Biophys. Acta. 2013; 1830: 2160-2166.

Ventura F, Leandro P, Luz A, Rivera I, Silva MFB, Ramos R, Rocha H, Lopes A,  Fonseca H, Gaspar A, Diogo L, Martins E, Leão-Teles E, Vilarinho L, Tavares de Almeida I. Retrospective study of the medium-chain acyl-CoA dehydrogenase deficiency in PortugalClin. Genet. 2013; [Epub ahead of print].

Violante S, Ijlst L, Ruiter J, Koster J, van Lenthe H, Duran M, de Almeida IT, Wanders RJ, Houten SM, Ventura FV. Substrate specificity of human carnitine acetyltransferase: Implications for fatty acid and branched-chain amino acid metabolism. Biochim. Biophys. Acta. 2013; 1832: 773-779.

Violante S, Ijlst L, Te Brinke H, Koster J, de Almeida IT, Wanders RJ, Ventura FV, Houten SM. Peroxisomes contribute to the acylcarnitine production when the carnitine shuttle is deficient. Biochim. Biophys. Acta. 2013; 1831: 1467-1474.

Violante S, Ijlst L, Te Brinke H, Tavares de Almeida I, Wanders RJ, Ventura FV, Houten SM. Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines. FASEB J. 2013; 27: 2039-2044.

 

Barateiro A, Vaz AR, Silva SL, Fernandes A, Brites D. ER Stress, mitochondrial dysfunction and calpain/JNK activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin. Neuromol. Med. 2012; 14: 285-302

Barroso M, Rocha MS, Esse R, Gonçalves Jr I, Gomes AQ, Teerlink T, Jakobs C, Blom HJ, Loscalzo J, Rivera I, Tavares de Almeida I, Castro R. Cellular hypomethylation is associated with impaired nitric oxide production by cultured human endothelial cells. Amino. Acids. 2012; 42: 1903-1911.

Brito MA, Zurolo E, Pereira P, Barroso C, Aronica E, Brites D. Cerebellar axon/myelin loss, angiogenic sprouting, and neuronal increase of vascular endothelial growth factor in a preterm infant with kernicterus. J. Child. Neurol. 2012; 27: 615-624.

Cal PM, Vicente JB, Pires E, Coelho AV, Veiros LF, Cordeiro C, Gois PM. Iminoboronates: a new strategy for reversible protein modification. J. Am. Chem. Soc. 2012; 134: 10299-10305.

Cardoso FL, Kittel A, Veszelka S, Palmela I, Tóth A, Brites D, Deli MA, Brito MA. Exposure to lipopolysaccharide and/or unconjugated bilirubin impair the integrity and function of brain microvascular endothelial cells. PLoS One. 2012; 7: e35919.

Castro-Caldas M, Carvalho AN, Rodrigues E, Henderson C, Wolf CR, Gama MJ. Glutathione S-transferase pi mediates MPTP-induced c-Jun N-terminal kinase activation in the nigrostriatal pathway. Mol. Neurobiol. 2012; 45: 466-477.

Castro-Caldas M, Neves Carvalho A, Rodrigues E, Henderson C, Wolf CR, Rodrigues CMP, Gama MJ. Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson’s disease. Mol. Neurobiol. 2012; 46: 475-486.

Celestino-Soper PB, Violante S, Crawford EL, Luo R, Lionel AC, Delaby E, Cai G, Sadikovic B, Lee K, Lo C, Gao K, Person RE, Moss TJ, German JR, Huang N, Shinawi M, Treadwell-Deering D, Szatmari P, Roberts W, Fernandez B, Schroer RJ, Stevenson RE, Buxbaum JD, Betancur C, Scherer SW, Sanders SJ, Geschwind DH, Sutcliffe JS, Hurles ME, Wanders RJ, Shaw CA, Leal SM, Cook EH Jr, Goin-Kochel RP, Vaz FM, Beaudet AL. A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism. Proc. Natl. Acad. Sci. USA 2012; 109: 7974-7981.

Dias C, Testa B, Soveral G, Dias M, Constantino L. Screening of the inhibitory effect of xenobiotics on alcohol metabolism using S9 rat liver fractions. Toxicol. in Vitro 2012; 26: 1177-1180.

Esse R, Florindo C, Imbard A, Rocha MS, de Vriese AS, Smulders YM, Teerlink T, Tavares de Almeida I, Castro R, Blom HJ. Global protein and histone arginine methylation are affected in a tissue-specific manner in a rat model of diet-induced hyperhomocysteinemia. Biochim. Biophys. Acta. 2013; 1832: 1708-14.

Esse R, Rocha MS, Barroso M, Florindo C, Teerlink T, Kok RM, Smulders YM, Rivera I, Leandro P, Koolwijk P, Castro R, Blom HJ, de Almeida IT. Protein arginine methylation is more prone to inhibition by S-adenosylhomocysteine than DNA methylation in vascular endothelial cells. PLoS One 2013; 8: e55483.

Estudante M, Maya M, Morais JAG, Soveral G, Benet LZ. Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil. Molecular Pharmaceutics 2013; in press.

Estudante M, Morais JA, Soveral G, Benet LZ. Intestinal drug transporters: an overview. Advanced Drug Delivery Reviews 2012, in press.

Falcão AS, Silva RF, Vaz AR, Silva SL, Fernandes A, Brites D. Cross-talk between neurons and astrocytes in response to bilirubin: early beneficial effects. Neurochem. Res. 2013; 38: 644-59.

Fonseca MB, Nunes AF, Rodrigues CMP. c-Jun regulates the stability of anti-apoptotic ∆Np63 in amyloid β-induced apoptosis. J. Azheimers Dis. 2012; 28: 685-694.

Fonseca MB, Solá S, Xavier JM, Dionísio PA, Rodrigues CMP. Amyloid β peptides promote autophagy-dependent differentiation of mouse neural stem cells: Aβ-mediated neural differentiation. Mol. Neurobiol. 2013. [Epub ahead of print].

Gaspar JM, Martins A, Cruz R, Rodrigues CMP, Ambrósio AF, Santiago AR. Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose. Neuroscience. 2013;

Lavrado J, Borralho PM, Ohnmacht SA, Castro RE, Rodrigues CMP, Moreira R, Santos DJ, Neidle S, Paulo A. Synthesis, G-Quadruplex stabilisation, docking studies, and effect on cancer cells of indolo [3,2-b]quinolines with one, two, or three basic side chains. Chem. Med. Chem. 2013

Leitão L, Prista C, Moura TF, Loureiro-Dias MC, Soveral G. Grapevine Aquaporins: Gating of a Tonoplast Intrinsic Protein (TIP2;1) by Cytosolic pH. PLoS ONE 2012; 7(3): e33219.

Lo AC, Callaerts-Vegh Z, Nunes AF, Rodrigues CMP, D’Hooge R. Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice. Neurobiol. Dis. 2013; 50: 21-29.

Luís PB, Ruiter JP, Ijlst L, Diogo L, Garcia P, Tavares de Almeida I, Duran M, Wanders RJA and Silva MFB. Inhibition of 3-methylcrotonyl-CoA carboxylase explains the increased excretion of 3 hydroxyisovaleric acid in valproate-treated patients. J. Inher. Metab. Dis. 2012; 35: 443-449.

Machado MV, Ferreira DMS, Castro RE, Silvestre AR, Evangelista T, Coutinho J, Carepa F, Costa A, Rodrigues CMP, Cortez-Pinto H. Fatty muscle associates with severity of nonalcoholic fatty liver and insulin resistance: liver and muscle interplay. PLoS One 2012; 7(2): e31738.

Mansoor TA, Borralho PM, Dewanjee S, Mulhovo S, Rodrigues CMP, Ferreira MJ. Monoterpene bisindole alkaloids, from the African medicinal plant Tabernaemontana elegans, induce apoptosis in HCT116 human colon carcinoma cells. J. Ethnopharmacol. 2013; 149: 463-470.

Mansoor TA, Borralho PM, Luo X, Mulhovo S, Rodrigues CMP, Ferreira MJ. Apoptosis inducing activity of benzophenanthridine-type alkaloids and 2-arylbenzofuran neolignans in HCT116 colon carcinoma cells. Phytomedicine. 2013; 20: 923-929.

Mansoor TA, Ramalho RM, Rodrigues CMP, Ferreira MJ. Dibenzylbutane- and butirolactone-type lignans as apoptosis inducers in human hepatoma HuH-7 cells. Phytother. Res. 2012; 26: 692-696.

Mariano C, Palmela I, Pereira P, Fernandes A, Falcão AS, Cardoso FL, Vaz AR, Campos AR, Gonçalves-Ferreira A, Kim KS, Brites D, Brito MA. Tricellulin expression in brain endothelial and neural cells. Cell Tissue Res. 2013; 351: 397-407.

Martins AP, Ciancetta A, de Almeida A, Marrone A, Re N, Soveral G, Casini A. Aquaporin inhibition by gold(III) compounds: new insights. ChemMedChem. 2013; 8: 1086-1092.

Martins AP, Lopes PA, Madeira MS, Martins SV, Santos NC, Moura TF, Prates JA, Soveral G. Differences in lipid deposition and adipose membrane biophysical properties from lean and obese pigs under dietary protein restriction. Biochem. Biophys. Res. Commun. 2012; 423: 170–175.

Martins, A.P., Marrone, A., Ciancetta, A., Galán-Cobo, A., Echevarría, M., Moura, T.F., Re, N., Casini, A., Soveral, G. Targeting Aquaporin Function: Potent Inhibition of Aquaglyceroporin-3 by a Gold-based Compound. PLoS ONE 2012;7(5): e37435.

Mello-Vieira J, Sousa T, Coutinho A, Fedorov A, Lucas SD, Moreira R, Castro RE, Rodrigues CMP, Prieto M, Fernandes F. Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations. Biochim. Biophys. Acta. 2013; 1828: 2152-63.

Mendes MI, Colaço HG, Smith DE, Ramos RJ, Pop A, van Dooren SJ, Tavares de Almeida I, Kluijtmans LA, Janssen MC, Rivera I, Salomons GS, Leandro P, Blom HJ. Reduced response of Cystathionine Beta-Synthase (CBS) to S-Adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in Homocystinuria patients. J. Inher. Metab. Dis 2013; [Epub ahead of print].

Milagre I, Nunes MJ, Castro-Caldas M, Moutinho M, Gama MJ, Rodrigues E. Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter. J. Neurochem. 2012; 120: 220-229.

Milagre I, Olin M, Nunes MJ, Moutinho M, Lövgren-Sandblom A, Gama MJ, Björkhem I, Rodrigues E. Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells. Neurochem. Int. 2012; 60: 192-198.

Nunes AF, Amaral JD, Lo AC, Fonseca MB, Viana RJS, Callaerts-Vegh Z, D’Hooge R, Rodrigues CMP. TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid β deposition in APP/PS1 mice. Mol. Neurobiol. 2012; 45: 440-454.

Nunes MJ, Moutinho M, Gama MJ, Rodrigues CMP, Rodrigues E. Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux. PLoS One. 2013; 8: e53394.

Nunes MJ, Moutinho M, Milagre I, Gama MJ, Rodrigues E. Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2- Sp3-dependent pathway. J. Lipid. Res. 2012; 53: 1910-1919.

Palmela I, Sasaki H, Cardoso FL, Moutinho M, Kim KS, Brites D, Brito MA. Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining. Front. Cell. Neurosci. 2012; 6: 1-14.

Palmela I, Sasaki H, Cardoso FL, Moutinho M, Kim KS, Brites D, Brito MA. Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining. Front. Cell. Neurosci. 2012; 6: 22.

Pereira DM, Rodrigues PM, Borralho PM, Rodrigues CMP. Delivering the promise of miRNA cancer therapeutics. Drug Discov. Today. 2013; 18: 282-289.

Pinheiro A, Nunes MJ, Milagre I, Rodrigues E, Silva MJ, Tavares de Almeida I, Rivera I. Demethylation of the coding region triggers the activation of the human testis-specific PDHA2 gene in somatic tissues. PLoS One 2012; 7: e38076.

Pinheiro A, Nunes MJ, Milagre I, Rodrigues E, Silva MJ, Tavares de Almeida I, Rivera I. Demethylation of the coding region triggers the activation of the human testis-specific PDHA2 gene in somatic tissues. PLos. One 2012; 7: e38076.

Pinheiro A, Silva MJ, Graça I, Silva J, Sá R, Sousa M, Barros A, Tavares de Almeida I, Rivera I. Pyruvate dehydrogenase complex: mRNA and protein expression patterns of E1α subunit genes in human spermatogenesis. Gene 2012; 506: 173-178.

Pinton S, Sampaio TB, Ramalho RM, Rodrigues CMP, Nogueira CW. p,p’-Methoxyl-diphenyl diselenide prevents neurodegeneration and glial cell activation induced by streptozotocin in rats. J. Alzheimers. Dis. 2013; 33: 133-144.

Ramalho RM, Nunes AF, Dias RB, Amaral JD, Lo AC, D’Hooge R, Sebastião AM, Rodrigues CMP. Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice. Neurobiol. Aging. 2013; 34: 551-561.

Rastew E, Vicente JB, Singh U. Oxidative stress resistance genes contribute to the pathogenic potential of the anaerobic protozoan parasite, Entamoeba histolytica. Int. J. Parasitol. 2012; 42: 1007-15.

Rocha MS, Teerlink T, Janssen M, Kluijtmans L, Smulders Y, Jakobs C, Tavares de Almeida I, Rivera I, Castro R, Blom HJ. Asymmetric Dimethylarginine in Homocystinuria due to Cystathionine b-synthase Deficiency. Atherosclerosis 2012; 222: 508-511.

Santos DM, Santos MM, Moreira R, Solá S, Rodrigues CMP. Synthetic condensed 1,4-naphthoquinone derivative shifts neural stem cell differentiation by regulating redox state. Mol. Neurobiol. 2013; 47: 313-324.

Santos DM, Xavier JM, Solá S, Rodrigues CMP. Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation. PLoS One 2012; 7(3):e33468.

Sá-Pereira I, Brites D, Brito MA. Neurovascular Unit: a Focus on Pericytes. Mol. Neurobiol. 2012; 45: 327-347.

Silva A, Luís D, Santos S, Silva J, Mendo AS, Coito L, Silva TF, da Silva MF, Martins LM, Pombeiro AJ, Borralho PM, Rodrigues CMP, Cabral MG, Videira PA, Monteiro C, Fernandes AR. Biological characterization of the antiproliferative potential of Co(II) and Sn(IV) coordination compounds in human cancer cell lines: a comparative proteomic approach. Drug. Metabol. Drug Interact. 2013; 28: 167-176.

Silva SL, Vaz AR, Diógenes MJ, van Rooijen N, Sebastião AM, Fernandes A, Silva RFM, Brites D. Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10. Neuropharmacology 2012; 62: 2398-2408.

Silva TFS, Martins LMDRS, Guedes da Silva MF, Fernandes AR, Silva A, Borralho PM, Santos S, Rodrigues CMP, Pombeiro AJL. Cobalt complexes bearing scorpionate ligands: synthesis, characterization and application as in vitro tumor-inhibitors. Dalton Transact. 2012; 41: 12888-12897.

Simões AE, Pereira DM, Amaral JD, Nunes AF, Gomes SE, Rodrigues PM, Lo AC, D’Hooge R, Steer CJ, Thibodeau SN, Borralho PM, Rodrigues CMP. Efficient recovery of proteins from multiple source samples after TRIzol(®) or TRIzol(®)LS RNA extraction and long-term storage. BMC Genomics. 2013; 14: 181.

Smith D, Mendes MI, Kluitjmans LA, Janssen MC, Smulders YM, Blom HJ. A liquid chromatography mass spectrometry method for the measurement of cystathionine β-synthase activity in cell extracts. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 2012; 911: 186-191.

Solá S, Aranha MM, Rodrigues CMP. Driving apoptosis-relevant proteins toward neural differentiation. Mol. Neurobiol. 2012; 46: 316-313.

Solá S, Morgado AL, Rodrigues CMP. Death receptors and mitochondria: two prime triggers of neural apoptosis and differentiation. Biochim. Biophys. Acta. 2013; 1830: 2160-2166.

Ventura F, Leandro P, Luz A, Rivera I, Silva MFB, Ramos R, Rocha H, Lopes A,  Fonseca H, Gaspar A, Diogo L, Martins E, Leão-Teles E, Vilarinho L, Tavares de Almeida I. Retrospective study of the medium-chain acyl-CoA dehydrogenase deficiency in PortugalClin. Genet. 2013; [Epub ahead of print].

Viana RJS, Nunes AF, Rodrigues CMP. Endoplasmic reticulum enrollment in Alzheimer’s disease. Mol. Neurobiol. 2012; 46: 522-534.

Vicente JB, Tran V, Pinto L, Teixeira M, Singh U. A detoxifying oxygen reductase in the anaerobic protozoan Entamoeba histolytica. Eukaryot. Cell. 2012; 11: 1112-18.

Violante S, Ijlst L, Ruiter J, Koster J, van Lenthe H, Duran M, de Almeida IT, Wanders RJ, Houten SM, Ventura FV. Substrate specificity of human carnitine acetyltransferase: Implications for fatty acid and branched-chain amino acid metabolism. Biochim. Biophys. Acta. 2013; 1832: 773-779.

Violante S, Ijlst L, Te Brinke H, Koster J, de Almeida IT, Wanders RJ, Ventura FV, Houten SM. Peroxisomes contribute to the acylcarnitine production when the carnitine shuttle is deficient. Biochim. Biophys. Acta. 2013; 1831: 1467-1474.

Violante S, Ijlst L, Te Brinke H, Tavares de Almeida I, Wanders RJ, Ventura FV, Houten SM. Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines. FASEB J. 2013; 27: 2039-2044.

 

Aires CC, Cruchten AV, Ijlst L, de Almeida IT, Duran M, Wanders RJ, Silva MF. New insights on the mechanisms of valproate-induced hyperammonemia: Inhibition of hepatic N-acetylglutamate synthase activity by valproyl-CoA. J. Hepatol. 2011; 55: 426-434.

Aranha MM, Santos DM, Solá S, Steer CJ, Rodrigues CMP. miR-34a regulates mouse neural stem cell differentiation. PLoS One 2011; 6: e21396.

Borralho PM, Simões AES, Gomes SE, Lima RT, Carvalho T, Ferreira DMS, Vasconcelos MH, Castro RE, Rodrigues CMP. miR-143 overexpression reduces the growth of xenograft tumors from colon carcinoma cells with increased apoptosis and reduced proliferation. PLoS One 2011; 6: e23787.

Brites D. Bilirubin injury to neurons and glial cells: new players, novel targets, and newer insights. Semin. Perinatol. 2011; 35: 114-20.

Campos E, Moura TF, Oliva A, Leandro P, Soveral G. Lack of Aquaporin 3 in bovine erythrocyte membranes correlates with low glycerol permeation. Biochem. Biophys. Res. Commun. 2011; 408: 477-481.

Fernandes A, Barateiro A. Falcão AS, Silva, SL, Vaz AR, Brito MA Silva, RFM, Brites D. Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways. Glia 2011; 59: 14-25.

Ferreira DMS, Castro RE, Machado MV, Evangelista T, Silvestre A, Costa A, Coutinho J, Carepa F, Cortez-Pinto H, Rodrigues CMP. Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease. Diabetologia 2011; 54: 1788-1798.

Handy DE, Castro R, Loscalzo J. Epigenetic Modifications: Basic Mechanisms and Role in Cardiovascular Disease. Circulation 2011; 123: 2145-2156.

Lopes PA, Martins SV, Viana RJS, Ramalho RM, Alfaia CM, Pinho MS, Jerónimo E, Bessa RJB, Castro MF, Rodrigues CMP, Prates JAM. Contrasting apoptotic responses of conjugated linoleic acid in the liver of obese Zucker rats fed palm oil or ovine fat. Prostag. Lekotr. Ess. 2011; 85: 89-96.

Luís PB, Ruiter JP, Ijlst L, Tavares de Almeida I, Duran M, Mohsen AW, Vockley J, Wanders RJ, Silva MF. Role of isovaleryl-CoA dehydrogenase and short branched-chain acyl-CoA dehydrogenase in the metabolism of valproic acid: implications for the branched-chain amino acid oxidation pathway. Drug. Metab. Dispos. 2011; 39: 1155-1160.

Luís PB, Ruiter JP, Ofman R, Ijlst L, Moedas M, Diogo L, Garcia P, de Almeida IT, Duran M, Wanders RJ, Silva MF. Valproic acid utilizes the isoleucine breakdown pathway for its complete β-oxidation. Biochem. Pharmacol. 2011; 82: 1740-1746.

Mansoor TA, Ramalho RM, Luo X, Ramalhete C, Rodrigues CM, Ferreira MJ. Isoflavones as apoptosis inducers in human hepatoma HuH-7 cells. Phytother Res. 2011; 25: 1819- 1824.

Mariano C, Silva SL, Pereira P, Fernandes A, Brites D, Brito MA. Evidence of tricellulin expression by immune cells, particularly microglia. Biochem. Biophys. Res. Commun. 2011; 409: 799-802.

Martins AP, Lopes PA, Costa AS, Martins SV, Santos NC, Prates JA, Moura TF, Soveral G. Differential mesenteric fat deposition in bovines fed on silage or concentrate is independent of glycerol membrane permeability. Animal 2011; 5 (12): 1949-1956.

Oberg AL, French AJ, Sarver AL, Subramanian S, Morlan BW, Riska SM, Borralho PM, Cunningham JM, Boardman LA, Wang L, Smyrk TC, Asmann Y, Steer CJ, Thibodeau SN. miRNA expression in colon polyps provides evidence for a multihit model of colon cancer. PLoS One 2011; 6: e20465.

Palmela I, Cardoso FL, Bernas M, Correia L, Vaz AR, Silva RFM, Fernandes A, Kim KS, Brites D, Brito MA. Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity. Curr. Neurovasc. Res. 2011; 8: 153-169.

Rivera I, Mendes D, Afonso A, Barroso M, Ramos R, Janeiro P, Oliveira A, Gaspar A, Tavares de Almeida I. Phenylalanine hydroxylase deficiency: Molecular epidemiology and predictable BH(4)-responsiveness in South Portugal PKU patients. Mol. Genet. Metab. 2011; 104 Suppl: S86-92.

Rodríguez IA, Silva RS, Martins AP, Soveral G., López-Barneo J, Aral JJ, Echevarría M. Functional and transcriptional induction of Aquaporin-1 gene by hypoxia; analysis of promoter and role of Hif-1. PLoS ONE 2011; 6(12): e28385.

Silva SL, Osório C, Vaz AR, Barateiro A, Falcão AS, Silva RF, Brites D. Dynamics of neuron-glia interplay upon exposure to unconjugated bilirubin. J. Neurochem. 2011; 117: 412-424.

Solá S, Xavier JM, Santos DM, Aranha MM, Morgado AL, Jepsen K, Rodrigues CMP. p53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation. PLoS One 2011; 6: e18421.

Soveral G, Prista C, Moura TF, Loureiro-Dias MC. Yeast Water Channels: an overview of orthodox aquaporins. Biology of the Cell 2011; 103: 35-54.

Vaz AR, Silva SL, Barateiro A, Falcão AS, Fernandes A, Brito MA, Brites D. Selective vulnerability of rat brain regions to unconjugated bilirubin. Mol. Cell. Neurosci. 2011; 48: 82-93.

Vaz AR, Silva SL, Barateiro A, Fernandes A, Falcão AS, Brito MA, Brites D. Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin. Exp. Neurol. 2011; 229: 381-390.

Viana RJS, Steer CJ, Rodrigues CMP. Amyloid β peptide-induced secretion of endoplasmic reticulum chaperone glycoprotein GRP94. J. Alzheimers Dis. 2011; 27: 61- 73.

 

Ravasco P, Aranha MM, Borralho PM, Moreira da Silva IB, Correia L, Fernandes A, Rodrigues CMP, Camilo ME. Colorectal cancer: can nutrients modulate NF-kappaB and apoptosis? Clin. Nutr. 2010; 29: 42-46.

Parry G, Rodrigues CMP, Aranha MM, Hilbert, Davey, Low WC, Steer CJ. Safety, tolerability and cerebral spinal fluid penetration of ursodeoxycholic acid in patients with amyotrophic lateral sclerosis. Clinic. Neuropharmacol. 2010; 33: 17-21.

Amaral JD, Xavier JM, Steer CJ, Rodrigues CMP. The role of p53 in apoptosis. Discov. Med. 2010; 9: 145-152.

Nunes MJ, Milagre I, Schnekenburger M, Gama MJ, Diederich M, Rodrigues E. Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription. J. Neurochem. 2010; 113: 418-431.

Amaral JD, Correia AR, Steer CJ, Gomes CM, Rodrigues CMP. No evidence of direct binding between ursodeoxycholic acid and the p53 DNA-binding domain. Biosci. Rep. 2010; 30: 359-364.

Viana RJS, Fonseca MB, Ramalho RM, Nunes AF, Rodrigues CMP. Organelle dysfunction and cell death mechanisms in neurodegenerative diseases. CNS Neurol. Disord. – Drug Targets 2010; 9: 679-692.

Amaral JD, Xavier JM, Steer CJ, Rodrigues CMP. p53, A guardian of apoptosis. Curr. Pharm. Design 2010; 16: 2493-2503.

Castro RE, Santos MMM, Glória PMC, Ribeiro CJA, Ferreira DMS, Xavier JM, Moreira R, Rodrigues CMP. Cell death targets in Alzheimer’s disease and potential modulators. Curr. Pharm. Design 2010; 16: 2851-2864.

Castro RE, Ferreira DMS, Zhang X, Borralho PM, Sarver AL, Zeng Y, Steer CJ, Kren BT, Rodrigues CMP. Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid. Am. J. Physiol. – Gastrointest. Liver Physiol. 2010; 299: G887-897.

Aranha MM, Santos DM, Xavier JM, Low WC, Steer CJ, Solá S, Rodrigues CMP. Apoptosis-associated microRNAs are modulated in mouse, rat and human neural differentiation. BMC Genomics 2010; 11: 514.

Amaral JD, Castro RE, Solá S, Steer CJ, Rodrigues CMP. Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53. Biochem. Biophys. Res. Commun. 2010; 400: 649-654.

Brito MA, Vaz AR, Silva SL, Falcão AS, Fernandes A, Silva RF, Brites D. N-methyl-Daspartate receptor and neuronal nitric oxide synthase activity on mediate bilirubin-induced neurotoxicity. Mol Med. 2010; 16: 372-80.

Vaz AR, Delgado-Esteban M, Brito MA, Bolaños JP, Brites D, Almeida A. Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid. J. Neurochem. 2010; 112: 56-65.

Bernas MJ, Cardoso FL, Daley SK, Weinand ME, Campos AR, Gonçalves Ferreira AJ, Hoying JB, Witte MH, Brites D, Persidsky Y, Ramirez SH, Brito MA. Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier. Nat Protoc. 2010; 5: 1265-1272.

Silva SL, Vaz AR, Barateiro A, Falcão AS, Fernandes A, Brito MA, Silva RFM, Brites D. Features of bilirubin-induced reactive microglia: from phagocytosis to inflammation. Neurobiol. Dis. 2010; 40: 663-675.

Cardoso FL, Sousa D, Brites D, Brito MA. Looking at the blood-brain barrier: molecular anatomy and possible investigation approaches. Brain Res. Ver. 2010; 64: 328-363.

Martins AP, Lopes PA, Martins SV, Madeira A, Santos NC, Prates J, Moura TF, Soveral G. Conjugated Linoleic Acid Reduces Permeability and Fluidity of Adipose Plasma Membranes from Obese Zucker Rats. Biochem. Biophys. Res. Commun. 2010; 398: 199-204.

Madeira A, Leitão L, Soveral G, Dias P, Prista C, Moura T, Loureiro-Dias MC. Effect of Ethanol on Fluxes of Water and Protons across the Plasma Membrane of Saccharomyces cerevisiae. FEMS Yeast Research 2010; 10: 252-258.

Aires CC, Ijlst L, Stet F, Prip-Buus C, de Almeida IT, Duran M, Wanders RJ, Silva MF. Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis. Biochem. Pharmacol. 2010; 79: 792-799. 

Castro R, Barroso M, Rocha M, Esse R, Ramos R, Ravasco P, Rivera I, de Almeida IT. The TCN2 776CNG polymorphism correlates with vitamin B(12) cellular delivery in healthy adult populations. Clin. Biochem. 2010; 43: 645-649.

Nascimento C, Leandro J, Lino PR, Ramos L, Almeida AJ, de Almeida IT, Leandro P. Polyol additives modulate the in vitro stability and activity of recombinant human phenylalanine hydroxylase. Appl. Biochem. Biotechnol. 2010; 162: 192-207.

Pinheiro A, Faustino I, Silva MJ, Silva J, Sá R, Sousa M, Barros A, de Almeida IT, Rivera I. Human testis-specific PDHA2 gene: methylation status of a CpG island in the open reading frame correlates with transcriptional activity. Mol. Genet. Metab. 2010; 99: 425-430.

Rocha MS, Castro R, Rivera I, Kok RM, Smulders YM, Jakobs C, de Almeida IT, Blom HJ. Global DNA methylation: comparison of enzymatic- and non-enzymatic-based methods. Clin. Chem. Lab. Med. 2010; 48: 1793-1798.

Violante S, Ijlst L, van Lenthe H, de Almeida IT, Wanders RJ, Ventura FV. Carnitine palmitoyltransferase II: New insights on the substrate specificity and implications for acylcarnitine profiling. Biochim. Biophys. Acta. 2010; 1802: 728-732

 

Amaral JD, Solá S, Steer CJ, Rodrigues CMP. Role of nuclear steroid receptors in apoptosis. Curr. Med. Chem. 2009; 16: 3886-3902.

Amaral JD, Steer CJ, Rodrigues CMP. p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis. Trends Mol. Med. 2009; 15: 531-541.

Amaral JD, Viana RJS, Steer CJ, Rodrigues CMP. Bile acids: regulation of apoptosis by ursodeocycholic acid. J. Lipid Res. 2009; 50: 1721-1734.

Aranha MM*, Solá S*, Low WC, Steer CJ, Rodrigues CMP. Caspases and p53 modulate FOXO3A/Id1 signaling during mouse neural stem cell differentiation. J. Cell. Biochem. 2009; 107: 748-758. *Equal contribution

Borralho PM, Kren BT, Castro RE, Moreira da Silva IB, Steer CJ, Rodrigues CMP. microRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells. FEBS J. 2009; 276: 6689-6700.

Brites D, Fernandes A, Falcão AS, Gordo AC, Silva RF, Brito MA. Biological risks for neurological abnormalities associated with hyperbilirubinemia. J. Perinatol. 2009; 29 Suppl 1:S8-13.

Cascalheira JF, João SS, Pinhanços SS, Castro R, Palmeira M, Almeida S, Faria MC, Domingues FC. Serum homocysteine: interplay with other circulating and genetic factors in association to Alzheimer’s type dementia. Clin. Biochem. 2009; 42: 783-790.

Castro-Caldas M, Milagre I, Rodrigues E, Gama MJ. Glutathione S-transferase pi regulates UV-induced JNK signaling in SH-SY5Y neuroblastoma cells. Neurosci. Lett. 2009; 451: 241-245.

Castro-Caldas M, Neves Carvalho A, Peixeiro I, Rodrigues E, Lechner MC, Gama MJ. GSTpi expression in MPTP-induced dopaminergic neurodegeneration of C57BL/6 mouse midbrain and striatum. J. Mol. Neurosci. 2009; 38: 114-127.

Costa E, Vieira E, Lopes AI, Saldanha MJ, Brites D, Dos Santos R. Identification of a novel deletion in UDP-glucuronosyltransferase gene in a patient with Crigler-Najjar syndrome type I. Blood Cells Mol. Dis. 2009; 42:265-6.

Diogo L, Grazina M, Garcia P, Rebelo O, Veiga MA, Cuevas J, Vilarinho L, de Almeida IT, Oliveira CR. Pediatric mitochondrial respiratory chain disorders in the Centro region of Portugal. Ped. Neurol. 2009; 40: 351-356.

Fernandes A, Brites D. Contribution of inflammatory processes to nerve cell toxicity by bilirubin and efficacy of potential therapeutic agents. Curr Pharm Des. 2009; 15:2915-26.

Fernandes A, Falcão AS, Abranches E, Bekman E, Henrique D, Lanier LM, Brites D. Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis. Dev Neurobiol. 2009; 69:568-82.

Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Ashkenazi A, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell SA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner M, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine S, Lipton SA, Lugli E, Madeo F, Malorni W, Marine J-CW, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JWM, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Scorrano L, SimonH-U, Steller H, Tschopp, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 2009; 16: 1093-1107.

Mansoor TA, Ramalho RM, Mulhovo S, Rodrigues CMP, Ferreira MJU. Induction of apoptosis in HuH-7 cancer cells by monoterpene and beta-carboline indole alkaloids isolated from the leaves of Tabernaemontana elegans. Bioorg. Med. Chem. Lett. 2009; 19: 4255-4258.

Popko J, Fernandes A, Brites D, Lanier LM. Automated Analysis of NeuronJ Tracing data. Cytometry Part A 2009; 75: 351-6.

Reimão S, C Morgado; I T Almeida; M Silva, H Corte Real, J Campos. 3-Hydroxy-3-Methylglutaryl Coenzyme A Lyase Deficiency: Initial presentation in a young adult. J. Inher. Metab. Dis. 2009; 32 Suppl 1: S49-52.

Santos DM, Santos MMM, Viana RJS, Castro RE, Moreira R, Rodrigues CMP. Naphtho[2,3-d]isoxazole-4,9-dione-3-carboxylates: potent, non-cytotoxic, anti- apoptotic agents. Chemico-Biol. Interact. 2009; 180: 175-182.

Sarver AL, French AJ, Borralho PM, Thayanithy V, Oberg AL, Silverstein KA, Morlan BW, Riska SM, Boardman LA, Cunningham JM, Subramanian S, Wang L, Smyrk TC, Rodrigues CMP, Thibodeau SN, Steer CJ. Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states. BMC Cancer 2009; 9: 401.

Silva MJ, Pinheiro A, Eusébio F, Gaspar A, Tavares de Almeida I, Rivera I. Pyruvate dehydrogenase deficiency: identification of a novel mutation in the PDHA1 gene which responds to amino acid supplementation. Eur. J. Pediatr. 2009; 168: 17-22

Soveral G, Martins AP, Martins SV, Lopes P, Alfaia C, Prates J, Moura TF.  Effect of dietary conjugated linoleic acid isomers on water and glycerol permeability of kidney membranes. Biochem. Biophys. Res. Commun. 2009; 383: 108-112.

Viana RJS, Nunes AF, Castro RE, Ramalho RM, Meyerson J, Fossati S, Ghiso J, Rostagno A, Rodrigues CMP. Tauroursodeoxycholic acid prevents E22Q Alzheimer’s Abeta toxicity in human cerebral endothelial cells. Cell. Mol. Life Sci. 2009; 66: 1094-1104.