2015 | 2014 | 201320122011 | 2010 | 20092008 | Patentes

    • 2016

Bárcia RN, Santos JM, Teixeira M, Filipe M, Pereira AR, Ministro A, Água-Doce A, Carvalheiro M, Gaspar MM, Miranda JP, Graça L, Simões S, Santos SC, Cruz P, Cruz H. 2016. Umbilical cord tissue-derived mesenchymal stromal cells maintain immunomodulatory and angiogenic potencies after cryopreservation and subsequent thawing. Cytotherapy. 2016 Dec 28. pii: S1465-3249(16)30587-4.

Bettencourt AF, et al. An acrylic reline resin loaded with chlorhexidine: Insights on drug release. Rev Port Estomatol Med Dent Cir Maxilofac. 2016. /j.rpemd.2016.04.001

Cipriano M, Correia JC, Camões SP, Oliveira NG, Cruz P, Cruz H, Castro M, Ruas JL, Santos JM, Miranda JP. 2016. The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells. Arch Toxicol. [Epub ahead of print]

Cipriano M, Freyer N, Knöspel F, Oliveira NG, Barcia R, Cruz PE, Cruz H, Castro M, Santos JM, Zeilinger K, Miranda  2016. Self-assembled 3D spheroids and hollow-fibre bioreactors improve MSC-derived hepatocyte-like cell maturation in vitro. Arch Toxicol. [Epub ahead of print]

Costa JG, Saraiva N, Guerreiro PS, Louro H, Silva MJ, Miranda JP, Castro M, Batinic-Haberle I, Fernandes AS, Oliveira NG. 2016. Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: an integrative approach of complementary endpoints. Food Chem Toxicol. 87:65-76. DOI: 10.1016/j.fct.2015.11.018
DOI: 10.1016/j.jcyt.2016.11.008.

Faustino, C., Bettencourt, A.F., Alfaia, A., Pinheiro, L. Conceitos Básicos de Reologia. Sua aplicação a alimentos, cosméticos e excipientes farmacêuticos. Química, 2016;140, 37-41.

Figueiredo, N.L.L., Canário, J., O’Driscoll, Duarte, A. and Carvalho, C. 2016. Aerobic mercury-resistant bacteria alter Mercury speciation and retention in the Tagus estuary (Portugal). Ecotoxicology and Environmental Safety, 124:60-67. doi: 10.1016/j.ecoenv.2015.10.001. Epub 2015 Oct 19.

Guerreiro PS, Estácio SG, Antunes F, Fernandes AS, Pinheiro PF, Costa JG, Castro M, Miranda JP, Guedes RC*, Oliveira NG*. Structure-based virtual screening toward the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1. Chem Biol Drug Des. 88(6):915-925. DOI: 10.1111/cbdd.12826.

Marinho AT, Dias CG, Pinheiro PF, Lemos AR, Antunes AM, Marques MM, Monteiro EC, Miranda JP*, Pereira SA*. 2016. Nevirapine modulation of paraoxonase-1 in the liver: an in vitro three-model approach. Eur J Pharm Sci. 82: 147-153.DOI: 10.1016/j.ejps.2015.11.019

Marques CF, Matos AC, Ribeiro IA, Gonçalves LM, Bettencourt A, Ferreira JM. Insights on the properties of levofloxacin-adsorbed Sr- and Mg-doped calcium phosphate powders. J Mater Sci Mater Med. 2016 Jul;27(7):123. doi: 10.1007/s10856-016-5733-2. Epub 2016 Jun 14

Nimb S, Mónico A, Rawalb M K, Duarte N, Prasad R, Di Pietro A, Ferreira MJU. Overcoming multidrug resistance in Candida albicans: macrocyclic diterpenes from Euphorbia species as potent inhibitors of drug-efflux pumps. Planta Medica 2016 (in press). DOI: 10.1055/s-0042-106169

Pinheiro PF, Pereira SA, Harjivan SG, Martins IL, Marinho AT, Cipriano M, Jacob CC, Oliveira NG, Castro MF, Marques MM, Antunes AM, Miranda  2016. Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study. Arch Toxicol [Epub ahead of print]

Salma Saoudi, Nadia Chammem, Ines Sifaoui, Maha Bouassida-Beji, Ignacio A. Jiménez, Isabel L. Bazzocchi, Sandra Diniz Silva, Moktar Hamdi, Maria Rosário Bronze  Influence of Tunisian aromatic plants on the prevention of oxidation in soybean oil under heating and frying conditions Food Chem.  2016; 212, 503-511

Serafim, C., Ferreira, I., Rijo, P., Pinheiro, L., Faustino, C., Calado, A., Garcia-Rio, L. Lipoamino acid-based micelles as promising delivery vehicles for monomeric amphotericin B. International Journal of Pharmacy, 2016; 497 (1), 23-35. Doi: 10.1016/j.ijpharm.2015.11.034

Susana Calado, Carla Eleutério, Eduarda Mendes, Maria de Jesus Rocha, Ana Paula Francisco and Maria Manuela Gaspar. Nanoformulations of a Triazene Analogue with Specific Affinity to Human Melanoma. J Nanosci Adv Tech, 2016;1(4): 1-9.

Vanessa de Jesus Gaffney, Helder Mota-Filipe, Rui Amaro Pinto, Chris Thiemermann, Marta Loureiro, Vitor Vale Cardoso, Maria João Benoliel, and Cristina M. M. Almeida. Chemical and biochemical characterization and in vivo safety evaluation of pharmaceuticals in drinking water. Environ Toxicol Chem. 2016; Accepted Author Manuscript. Doi:10.1002/etc.3451

V. Gaffney, V. V. Cardoso, M. J. Benoliel, C. M. M. Almeida,.Chlorination and oxidation of sulfonamides by free chlorine: Identification and behaviour of reaction products by UPLC-MS/MS, Journal of Environmental Management, 2016;166, 466-477.

Wilks MF, Blaauboer BJ, Schulte-Hermann R, Wallace HM, Galli CL, Grönlund MH, Matovic V, Teixeira JP, Ziliacus J, Basaran N, Bonefeld E, Bourrinet P, Brüller W, Claude N, Miranda JP, Gundert-Remy U, Hakansson H, Kovatsi L, Liesivuori J, Linderman B, Lison D, Leconte D, Matinez E, Murias M, Michel C, Scheepers P, Stanley L, Tsatsakis A. 2016. The European Registered Toxicologist (ERT): Current status and prospects for advancement. Tox Letters. [Epub ahead of print]

Wisniewski J, Wesolowska O, Paprocka M, Pomianek K, Pohl A, Dús D, Duarte N, Ferreira MJ, Michalak K. Euphorbia Species-derived Diterpenes and Coumarins as Multidrug Resistance Modulators in Human Colon Carcinoma Cells. Anticancer Research 2016, 36(5): 2259-64.

Capítulos de livros

Andreia Mónico, Angela Paterna, Mariana A. Reis, Ricardo Ferreira, Noélia Duarte, Ana M. Madureira, and Maria-José U. Ferreira. Isolation and Structural Identification of Piperine, the Major Alkaloid of Black Pepper. Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. Edited by Carlos A. M. Afonso, Nuno R. Candeias, Dulce Pereira Simão, Alexandre F. Trindade, Jaime A. S. Coelho, Bin Tan, and Robert Franzén. © The Royal Society of Chemistry, 2016.

Costa, J., Franco Machado, J., Cabral, M.F., 2016. Preparation of a thia-tetraaza macrocyclic compound through a dual-step synthesis,. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. Afonso, C.A.M., Candeias, N.R., Simão, D., Trindade, A., Coelho, J., Tan, B., Franzén, R. (Eds). Royal Society of Chemistry, U.K., pp 911-915. ISBN: 978-1-84973-963-4.


A. Mata, J.P. Ferreira, C. Semedo, T. Serra, C.M.M. Duarte, M.R. Bronze, Contribution to the characterization of Opuntia spp. juices by LC–DAD–ESI-MS/MS, Food Chem. A. Mata, J.P. Ferreira, C. Semedo, T. Serra, C.M.M. Duarte, M.R. Bronze. Contribution to the characterization of Opuntia spp. juices by LC–DAD–ESI-MS/MS, Food Chem. 2015; 210, 558–565. DOI; 10.1016/j.foodchem.2016.04.033

Andrade, VM, Mateus, ML, Batoréu, MC, Aschner, M and Marreilha dos Santos, AP. Lead, Arsenic, and Manganese Metal Mixture Exposures: Focus on Biomarkers of Effect. Biol Trace Elem Res, 2015. DOI 10.1007/s12011- 015-0267-x;

Baptista R, Madureira AM, Jorge R, Adão R, Duarte A, Duarte N, Lopes M M, Teixeira G. Antioxidant and antimycotic activities of two Lavandula species native from Portugal. Evidence-Based Complementary and Alternative Medicine, Volume 2015, Article ID 570521, 2015.

Branco, M.A., Pinheiro, L., Faustino, C. Amino acid-based cationic gemini surfactant-protein interactions. Colloids Surf A: Physicochem. Eng. Aspects, 2015; 480, 105-112. (doi:

Brito H, Martins AC, Lavrado J, Mendes E, Francisco AP, Santos SA, et al. Targeting KRAS Oncogene in Colon Cancer Cells with 7- Carboxylate Indolo[ 3,2-b]quinoline Tri-Alkylamine Derivatives. PLoS ONE 2015; 10(5): e0126891. doi:10.1371/journal.pone.0126891

Cristina M. M. Almeida, Maria M. Lopes. Fungi isolated from traditional and exotic apple varieties from Portugal and patulin production, Journal of Pharmacy and Nutrition Sciences, 2015;5, 30-37.

Faustino, C., Bettencourt, A.F., Alfaia, A., Pinheiro, L. Introducing Students to Rheological Classification of Foods, Cosmetics, and Pharmaceutical Excipients Using Common Viscous Materials. J Chem Educ, 2015; 92, 936-939. doi:

Faustino, C., Serafim, C., Ferreira, I., Pinheiro, L., Calado, A. Solubilization power of an amino acid-based gemini surfactant towards the hydrophobic drug amphotericin B. Colloids Surf A: Physicochem. Eng. Aspects, 2015; 480, 426-432. (doi: 10.1016/j.colsurfa.2014.11.039).

Fernandes, A.S., Flórido, A., Saraiva, N., Cerqueira, S., Ramalhete, S., Cipriano, M., Cabral, M.F., Miranda, J.P., Castro, M., Costa, J., Oliveira, N.G. Role of the copper(II) complex Cu[15]pyN5 in intracellular ROS and breast cancer cell motility and invasion. Chem Biol Drug Des, 2015;1-11. doi: 10.1111/cbdd.12521.

Ferreira IFS, Bettencourt A, Betrisey B, Gonçalves LM, Trampuz A, Almeida AJ. Improvement of the Antibacterial Activity of Daptomycin-loaded Polymeric Microparticles by Eudragit RL 100: an Assessment by Isothermal Microcalorimetry. Int. J. of Pharm. 485 (2015) 171–182. 2015.

João Sebastião Rebelo, Mário Dias Almeida, Lucília Vales, Cristina M. M. Almeida. Presence of nitrates in baby foods marketed in Portugal, Cogent Food & Agriculture, 2015;1:1010414.

Karima Dhaouadi, Manel Belkhir, Faten Raboudi, Elsa Mecha, Imen Ghommeme, Maria Do Rosario Bronze, Hajer Ammar, Sami Fattouch. Pomegranate and mint syrup addition to green tea beverage stabilized its polyphenolic content and biofunctional potentials during refrigerated storage. J Food Sci Technol, 2015; 53, 2, 1164-1177.  DOI: 10.1007/s13197-015-2109-4.

Marques CF, Lemosa A, Lemosa A, Vieira SI, Cruz e Silva OAB, Bettencourt A, Ferreira JMF. Antibiotic-loadedSr doped porous calcium phosphate granules as multifunctional bonegrafts,Ceramics International 2015,

Mata, A.T., Ferreira, J.P., Oliveira B.R., Batoréu, M.C., Crespo, M.T. Barreto, Pereira, V.J., Bronze, M.R. Bottled water: Analysis of mycotoxins by LC–MS/MS. Food Chem., 2015; 176, 455–464. DOI: 10.1016/j.foodchem.2014.12.088

Matos A, Ribeiro I, Guedes R, Pinto R, Vaz M, Gonçalves L, Almeida AJ, Bettencourt A. Key- properties Outlook of a levofloxacin-loaded acrylic bone cement with improved antibiotic delivery. Int J Pharm. 2015 May 15;485(1-2):317-28. doi: 10.1016/j.ijpharm.2015.03.035.

Matos AC, Marques CF, Pinto RV, Ribeiro IA, Gonçalves LM, Vaz MA, Ferreira JM, Almeida AJ, Bettencourt AF4. Novel doped calcium phosphate-PMMA bone cement composites as levofloxacin delivery systems. Int J Pharm. 2015 Jul 25;490(1-2):200-8. doi: 10.1016/j.ijpharm.2015.05.038.

Matos, Ana M, Reis M, Duarte N, Spengler G, Molnár J, Ferreira MJU. Epoxylathyrol Derivatives: Modulation of ABCB1-mediated multidrug resistance in human colon adenocarcinoma and mouse T-lymphoma cells. Journal of Natural Products 2015, 78: 2215-2228 DOI: 10.1021/acs.jnatprod.5b00370.

Miranda JP, Filipe E, Fernandes AS, Almeida J, Martins JP, Barcia R, Cruz P, De la Fuente A, Abal M, Castro M, Cruz H, Santos JM. 2015. The human umbilical cord tissue-derived MSC population UCX® promotes early motogenic effects on keratinocytes and fibroblasts and G-CSF-mediated mobilization of BM-MSCs when transplanted in vivo. Cell Transplant. 24(5): 865-77. DOI: 10.3727/096368913X676231

Pinheiro PF, Marinho AT, Antunes AMM, Marques MM, Pereira SA, Miranda JP. 2015. Sex differences in hepatic and intestinal contributions to nevirapine biotransformation in rats. Chem Biol Interact. 233: 115-121. DOI: 10.1016/j.cbi.2015.03.024

Rodrigues, J., Branco V., Lu ,J., Holmgren, A., Carvalho, C. (2015). Toxicological effects of thiomersal and ethylmercury: Inhibition of the thioredoxin system and NADP(+)-dependent dehydrogenases of the pentose phosphate pathway. Toxicology and Applied Pharmacology,  2015; 286: 216-223. DOI: 10.1016/j.taap.2015.05.002

Santos-Ferreira I, Bettencourt A, Almeida AJ. Nanoparticulate Platforms for Targeting Bone Infections: Meeting a Major Therapeutic Challenge. Future Medicine Nanomedicine (Lond). 2015 Oct;10(20):3131-45. (invited opinion paper).

Santos-Ferreira I, Bettencourt A, Gonçalves LM, Kasper S, Bétrisey B, Kikhney J, Moter A, Trampuz A, Almeida AJ. Activity of Daptomycin and Vancomycin-loaded poly-epsilon-caprolactone microparticles against mature staphylococcal biofilms. Int J Nanomedicine, 2015, vol 15, pages 4351-4366. Doi:

Santos JM, Camões SP, Filipe E, Cipriano M, Barcia R, Filipe M, Teixeira M, Mosqueira D, Nascimento DS, Simões S, Gaspar M, Pinto-do-Ó P, Cruz P, Cruz H, Castro M, Miranda JP. 2015. 3D spheroid cell culture of umbilical cord tissue-derived MSCs (UCX®) leads to enhanced paracrine induction of wound healing. Stem Cell Res Ther.6(1):90-109.DOI:10.1186/s13287-015-0082-5

Silva S, Combet E, Figueira ME, Koeck T, Mullen W, Bronze MR. New perspectives on bioactivity of olive oil: evidence from animal models, human interventions and the use of urinary proteomic biomarkers. Proc Nutr Soc. 2015; 74(3):26881. DOI: 10.1017/S0029665115002323

Silva, S., Bronze, M. R., Figueira, M. E., Siwy, J., Mischak, H., Combet, E., Mullen W. Impact of a sixweek olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease and diabetes (types 1 & 2): a randomized, parallel, controlled, doubleblind study. Am J Clin Nutr. 2015; 101 ( 1), 44-54. doi: 10.3945/ajcn.114.094219.

V. Gaffney, C. M. M. Almeida, A. Rodrigues, E. Ferreira, M. J. Benoliel, V. V. Cardoso. Occurrence of pharmaceuticals in a water supply system and related human health risk assessment, Water Research, 2015; 72, 199-208.

Capítulos de livros

Bettencourt A., Almeida A. Poly(methyl methacrylate): Drug Delivery Applications. “Encyclopedia of Biomedical Polymers and Polymeric Biomaterials”, Taylor and Francis, ISBN1-13: 9781439898796) (2015).

Faustino, C., Pinheiro, L., 2015. Antimicrobial properties and therapeutic benefits of honey in the quest for more efficient antimicrobial agents, in: Méndez-Vilas (Ed.), The Battle Against Microbial Pathogens: Basic Science, Technological Advances and Educational Programs.Formatex, Badajoz, Spain, pp. 98–108.

Louro H., Bettencourt A, et al. Role of nanogenotoxicology studies in safety evaluation of nanomaterials. S. Thomas, Y. Grohens, N. Ninan: Nanotechnology Applications for Tissue Engineering. ISBN: 978-0-323-32889-0. Elsevier (2015)

Oliveira NG, Miranda JP, Fernandes AS, Castro MF. Biomarcadores em Toxicologia. In Toxicologia Forense, ed. Dinis-Oliveira RJ, Carvalho FC, Bastos ML, Pactor-LIDEL–Edições Técnicas, Lda., Portugal. pp 79-101. ISBN: 978-989-693-045-5


Andrade V, Mateus ML, Santos D, Aschner M, Batoreu MC, Marreilha dos Santos AP. Arsenic and Manganese Alter Lead Deposition in the Rat. Biol Trace Elem Res, 2014,158(3):384-91.DOI10.1007/s12011-014-9954-2.

Andrade, V, Mateus, ML, Batoréu, MC, Aschner, M and  Marreilha dos Santos, AP. Changes in rat urinary porphyrin profiles predict the magnitude of the neurotoxic effects induced by a mixture of lead, arsenic and manganese.  NeuroToxicology, 2014; 45, 168-177. DOI:10.1016/j.neuro.2014.10.009.

Branco V., Godinho-Santos, A., Gonçalves, J. LU, J., Holmgren, A., Carvalho, C. Mitochondrial thioredoxin reductase inhibition, selenium status and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds. Free Radical Biology and Medicine,  2014; 73: 95-105. DOI: 10.1016/j.freeradbiomed.2014.04.030

D. Santos, M. Camila Batoréu, M. Luísa Mateus, A.P. Marreilha dos Santos, Michael Aschner. Manganese in human parenteral nutrition: Considerations for toxicity and biomonitoring NeuroToxicology, 2014;

de Carvalho, G.G., Degaspari, I.A., Branco, V., Canário, J., de Amorim AF, Kennedy VH, Ferreira JR. Assessment of total and organic mercury levels in blue sharks (Prionace glauca) from the south and southeastern Brazilian coast. Biological Trace Element Research 2014; 159: 128-134. DOI: 10.1007/s12011-014-9995-6

de Sá, M., Ferreira, J.P., Queiroz, V.T., Vilas-Boas, L., Silva, M.C., Almeida, M.H., Guerra-Guimarães, L. and Bronze, M.R. A liquid chromatography/electrospray ionisation tandem mass spectrometry method for the simultaneous quantification of salicylic, jasmonic and abscisic acids in Coffea arabica leaves. Journal of the Science of Food and Agriculture. 2014; 94 (3), 529-536.

Eduarda Mendes, Maria de Jesus Perry, Ana Paula Francisco.  Design and discovery of mushroom tyrosinase inhibitors and their therapeutic applications. Expert Opinion on Drug Discovery, 2014; Vol. 9, No. 5, Pages 533-554 (doi:10.1517/17460441.2014.907789).

Faustino C, Bettencourt AF, Alfaia A, Pinheiro L. Introducing Students to Rheological Classification of Foods, Cosmetics, and Pharmaceutical Excipients Using Common Viscous Materials. J. Chem. Educ., DOI: 10.1021/ed4008364. 2015.

Ferreira MJ, Duarte N, Reis M, Madureira AM, Molnár J. Euphorbia and Momordica metabolites  for Overcoming Multidrug Resistance. Phytochemistry Reviews 2014, 13: 915 – 935. DOI 10.1007/s11101-014-9342-8.

Figueira, M.E., Câmara, M.B., Direito, R., Rocha, J.P., Serra, T., Duarte, C., Frenandes, A., Freitas, M., Fermnandes, E., Marques, M.C., Bronze, M.R., Sepodes, B. Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis, Food Funct. 2014; 5, 3241-3251.

Figueiredo, N.L.L., Canário, J., Duarte, A., Serralheiro, M.L., Carvalho, C. 2014. Isolation and characterization of mercury-resistant bacteria from sediments of tagus estuary (Portugal): Implications for environmental and human health risk assessment. Journal of Toxicology and Environmental Health – Part A: Current Issues 77: 155-168. doi: 10.1080/15287394.2014.867204.

Gaffney, V. Cardoso, A. Rodrigues, E. Ferreira, M. J.  Benoliel, C. M. M. Almeida. Analysis of Pharmaceutical Compounds in Water by SPE-UPLC-ESI-MS/MS, Química Nova , 2014; 37(1)138-149.

Jordi Juárez-Jiménez, Eduarda Mendes, Carles Galdeano, Carla Martins, Daniel B. Silva, José Marco-Contelles, Maria do Carmo Carreiras, F. Javier Luque, Rona R. Ramsay. Exploring the structural basis of the selective inhibition of monoamine oxidase A by dicarbonitrile aminoheterocycles: Role of Asn181 and Ile335 validated by spectroscopic and computational studies. Biochimica et Biophysica Acta 2014; 1844, 389–397.

Lopes, A., Silva, N., Bronze, M.R., Ferreira, J. and Morais, J. Analysis of cocaine and nicotine metabolites in wastewater by liquid chromatography-tandem mass spectrometry. Cross abuse index patterns on a major community. Science of the Total Environment, 2014; 487, 673-680.

M. Edite Torres, Luísa L. Gonçalves, M. Rosário Bronze, A.P. Marreilha dos Santos, M. Camila Batoréu, M. Luísa Mateus. Alternative Biomarkers of n-Hexane exposure: Characterization of aminoderived pyrroles and thiol-pyrrole conjugates in urine of rats exposed to 2,5-Hexanedione. Toxicology Letters, 2014, 224: 54– 63. j.toxlet.2013.10.011.

Madeira, Paulo J. Amorim, Sitoe, Ana Raquel Fernandes, Gonçalves, Daniel, Rodrigues, Tiago, Guedes, Rita C ., Lopes, Francisca, Moreira, Rui, Bronze,  M. Rosário. Antiplasmodial drugs in the gas phase: A C ID and DFT study of quinolon-4(1H)-imine derivatives. Journal of the American Society for Mass Spectrometry, 2014; 25, 9, 1650-1661.

Márcia Reto, Cristina Almeida, João Rocha, Bruno Sepodes, Maria-Eduardo Figueira. Green Tea (Camellia sinensis) Hypocholesterolemic Effects in Humans and Anti-Inflammatory Effects in Animals, Food and Nutrition Sciences, 2014; 5, 2185-2194.

Matos A., Gonçalves LM, Rijo P, Vaz M, Almeida AJ, Bettencourt A. A novel modified acrylic bone cement matrix. A step forward on antibiotic delivery against multiresistant bacteria responsible for prosthetic joint infections. Mat Sci and Engineering: C 2014. 38 (1), 218–226.

Mendes De Oliveira, MC; Pires Lopes, L; Miranda, J; Castro, M; Bettencourt, AF; Bettencourt Neves, C. Effects of salivary acetylcholinesterase on the cytotoxicity of acrylic reline resins. Rev Port Estomatol Med Dent Cir Maxilofac. 2014;55:7-13.

Neusa Figueiredo, Andreia Areias, Ricardo Mendes, João Canário, Aida Duarte, and Cristina Carvalho 2014. Mercury-resistant Bacteria from Salt Marsh of Tagus Estuary: the influence of plants presence and mercury contamination levels. Journal of Toxicology and Environmental Health – Part A: Current Issues 77:1–13. DOI: 10.1080/15287394.2014.911136

Nunes, E., Cavaco, A., Carvalho, C. 2014. Children’s health risk and benefits of fish consumption: Risk indices based on a diet diary follow-up of two weeks. Journal of Toxicology and Environmental Health – Part A: Current Issues 77:103 – 114. doi: 10.1080/15287394.2014.866926.

Nunes, E., Cavaco, A., Carvalho, C.2014. Exposure assessment of pregnant portuguese women to methylmercury through the ingestion of fish: Cross-sectional survey and biomarker validation. Journal of Toxicology and Environmental Health – Part A: Current Issues 77: 133 – 142. doi: 10.1080/15287394.2014.867200.

Oliveira MMC, Lopes LP, Miranda JP, Castro M, Bettencourt AF, Neves CB. 2014. Effects of salivary acetylcholinesterase on the cytotoxicity of acrylic reline resins.  Rev Port Estomatol Med Dent Cir Maxilofac. 55(1): 7-13. DOI: 10.1016/j.rpemd.2013.12.134

Oliveira Rudi, Guedes Rita C, Meireles Patricia, Albuquerque Inês S, Gonçalves Lídia M, Pires Elisabete, Bronze Maria Rosário, Gut Jiri, Rosenthal Philip J, Prudêncio Miguel, Moreira Rui, O’Neill Paul M, Lopes Francisca. Tetraoxane-Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials.  J. Med. Chem., 2014; 57 (11), 4916–4923.

Peres,  Cátia M., Alves,  Marta, Hernandez-Mendoza, Adrián, Moreira, Liliana, Silva, Sandra, Bronze, Maria R., Vilas-Boas, Luís, Peres, Cidália, Malcata, F. Xavier. Novel isolates of lactobacilli from fermented Portuguese olive as potential probiotics. LWT – Food Science and Technology, 2014; 59, Issue 1, 234-246.

Silva S., Sepodes, B., Rocha, J., Direito, R. Fernandes, A., Brites, D., Freitas, M., Fernandes, E., Bronze, M. R., Figueira M. E. Protective effects of hydroxytyrosol supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis.  J. Nutrit. Biochem., 2014; 26(4), 360-8. DOI: 10.1016/j.jnutbio.2014.11.011

Silva, Sandra D.; Feliciano, Rodrigo P.; Boas, Luis V.; et al., Application of FTIR-ATR to Moscatel dessert wines for prediction of total phenolic and flavonoid contents and antioxidant capacity. Food Chemistry, 2014; 150, 489-493.

Torres ME, Marreilha dos Santos AP, Goncalves L, Andrade V, Batoréu MC, Mateus ML. Role of N-Acetylcysteine in Protecting Against 2,5-Hexanedione Neurotoxicity in a Rat Model: Changes in urinary pyrroles levels and motor activity performance  Environmental Toxicology and Pharmacology, 2014, 38: 807-813; DOI:10.1016/j.etap.2014.09.008.

Torres, M.E., Gonçalves, L.L., Bronze, M.R., Santos, A.P.M.D., Batoréu, M.C. and Mateus, M.L. Alternative biomarkers of n-hexane exposure: Characterization of aminoderived pyrroles and thiol-pyrrole conjugates in urine of rats exposed to 2,5-hexanedione. Toxicology Letters 2014; 224, 54-63.

Torres, N., Gonçalves, S., Fernandes, A.S., Franco Machado, J., Villa Brito, M.J., Oliveira, N.G., Castro, M., Costa, J., Cabral, M.F. [15]aneN4S: Synthesis, thermodynamic studies and potential applications in chelation therapy. Molecules, 2014; 19, 550-567. doi: 10.3390/molecules19010550.

Vieira C, Duarte N, Reis M, Spengler G, Madureira AM,  Molnár J, Ferreira MJU. Improving the MDR reversal activity of 6,17-epoxylathyrane diterpenes. Bioorganic Medicinal chemistry, 2014, 22: 6392–6400.

Zancajo,  Victor M.R., Brito, J., Carrasco, Marta P., Bronze, M.R., Moreira, Rui, Lopes Alvaro. Analytical profiles of “legal highs” containing cathinones available in the area of Lisbon, Portugal.  Forensic Science International, 2014; 244, 102-110.


Capítulos de livros

Ana C. Ribeiro, Maria J. Silva, Maria E. Figueira. In Galactose, Struture and function in Biology and Medicine, 2014. Chapter 3- Galactose: Diet and its Implication in Galactosémia, 47-74. Vitor Hugo Pomin (edt), Novapublishers, New York. ISBN: 978-1-63117-928-0

Cristina M. M. Almeida, 2014. Fruit Juices: Types, Nutrition, Composition and Health Benefits, Chapter 4: Overview of Fruit Juices’ Composition: Health Benefits, Edited by Katherlyn Elizabeth Elder, Nova Science Publishers, New York, ISBN: 978-1-63321-135-3.


Andrade, V., Mateus, ML., Batoréu, MC., Aschner, M.,. Marreilha dos Santos, AP. Urinary delta-ALA: a potential biomarker of exposure and neurotoxic effect in rats co-treated with a mixture of lead, arsenic and manganese. NeuroToxicology, 2013, Vol 38, 33-41. (3.269).

A.S. Monteiro, J. Almeida, G. Cabral, P. Severino, P.A. Videira, A. Sousa, R. Nunes, J.D. Pereira, A.P. Francisco, M.J. Perry, E. Mendes, Synthesis and evaluation of N-acylamino acids derivatives of triazenes. Activation by tyrosinase in human melanoma cell lines, Eur J of Med Chem, 2013, doi: 10.1016/j.ejmech.2013.09.040 (in press).

Bandarra S, Fernandes AS, Magro I, Guerreiro PS, Pingarilho M, Churchwell MI, Gil OM, Batinic-Haberle I, Gonçalves S, Rueff J, Miranda JP, Marques MM, Beland FA, Castro M, Gaspar JF, Oliveira NG. Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells. Mutagenesis, 2013 (accepted 9th September, in press) 28(6): 721-9.  DOI: 10.1093/mutage/get052

Daniel Silva, Mourad ChiouaAbdelouahid SamadiPaula AgostinhoPedro Garção, Rocío Lajarín-CuestaCristobal de los Ríos,Isabel IriepaIgnacio Moraleda, Laura Gonzalez-Lafuente, Eduarda Mendes, Concepción PérezMaría Isabel Rodríguez-FrancoJosé Marco-Contelles, and M. Carmo Carreiras, “Synthesis, Pharmacological Assessment, and Molecular Modeling of Acetylcholinesterase/Butyrylcholinesterase Inhibitors: Effect against Amyloid-β-Induced Neurotoxicity”, CS Chem. Neurosci., 2013, 4 (4), pp 547–565.

Ferreira MJ, Luo X, Pires D, Ainsa JA, Gracia B, Duarte N, Mulhovo S, Anes E. Searching for natural antituberculars from mozambican medicinal plants. Conference Proceeding from International Congress “Saber Tropical em Moçambique: História, Memória e Ciência”. pp. 1 – 10. Instituto de Investigação Científica Tropical,. Lisboa 2013. ISBN 978-989-742-006-1

Fojo C, Figueira ME, Almeida CM., Fluoride contente of soft drinks, nectars, juices, juice drinks, concentrates, teas and infusions marketed in Portugal.  Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013, 30(4):705-12.

Gomes D., Pereira M., Bettencourt A. Osteomyelitis: an overview of antimicrobial therapy.  Brazilian Journal of Pharmaceutical Sciences 2013; 49(1); 13-27.

Guerreiro PS, Fernandes AS, Costa JG, Castro M, Miranda JP, Oliveira NG*. Differential effects of methoxyamine on the cytotoxicity and genotoxicity of doxorubicin in MDA-MB-231 human breast cancer cells, Mut Res, 2013 [Epub ahead of print]

Luo X, Pires D, Ainsa JA, Gracia B, Duarte N, Mulhovo S, Anes E, Ferreira MJ. Zanthoxylum capense constituents with antimycobacterial activity against Mycobacterium tuberculosis in vitro and ex vivo within human macrophages. Journal of Ethnopharmacology2013, 146: 417-22.

M. Carmo Carreiras, Eduarda Mendes, M. Jesus Perry, Ana Paula Francisco and J. Marco-Contelles. The Multifactorial Nature of Alzheimer`s Disease for Developing Potential Therapeutics. Current Topics in Medicinal Chemistry, 2013, 13, 1745-1770.

Martins IL, Miranda JP, Oliveira NG, Fernandes AS, Gonçalves S, Antunes AMM. 2013. Synthesis and biological activity of 6-seleno-caffeine: Potential modulator of chemotherapeutic drugs in breast cancer cells, Molecules, 2013, 18(5), 5251-5264

Neves B, Lopes L, Miranda J, Castro M, Bettencourt A. Ethanol post-polymerization treatment for improving the biocompatibility of acrylic relin resins. Biomed Res International. 2013; 485246, 9 pages.

Pingarilho M, Oliveira NG, Martins C, Gomes BC, Fernandes AS, Martins V, Labilloy A, de Lima JP, Rueff J, Gaspar JF. Induction of sister chromatid exchange by acrylamide and glycidamide in human lymphocytes: Role of polymorphisms in detoxification and DNA-repair genes in the genotoxicity of glycidamide, Mutat Res, 2013, 1-2: 1-7.

Pinheiro LMV, Moita MLCJ, Santos AFS, Lampreia IMS. Ultrasound Speeds and Molar Isentropic Compressions of 3-ethoxypropane-1-amine + water Mixtures from T = (283.15 to 303.15) K. J Chem Thermodynamics, 2013, 64, 93-99.

Prigol M, Nogueira CW, Zeni G, Bronze MR, Constantino L. Physicochemical and Biochemical Profiling of Diphenyl Diselenide, Appl Biochem Biotechnol2013, 169:885–893.

Ribeiro IA, Bronze MR, Castro MF, Ribeiro MHL. Sophorolipids: improvement of the selective production by Starmella bombicola through the design of nutritional requirements, Applied Microbiology and Biotechnology, 2013, 97(5): 1875-87.

Rodrigues T, da Cruz F, Monasterio MJ, Gonçalves D, Ressurreicao A, Sitoe A, Bronze  MR, Gut J, Schneider  G, Mota M, Rosenthal P, Prudêncio M, Gamo FJ, Lopes F, Moreira R. Quinolin-4(1H)-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria, J. Med. Chem., 2013, 56, 4811−4815.

Sá M, Ferreira J, Queiroz V,  Vilas-Boas  L,  Silva M,  Almeida M, Guerra-Guimarães L, Bronze, MR.  A liquid chromatography-electrospray tandem mass spectrometry method for the simultaneous quantification of salicylic, jasmonic, and abscisic acid in Coffea arabica leaves”, 2013, JSFA 6288.

Santos, D.,  Batoreu MC., Aschner, M.,  Marreilha dos Santos, AP. Comparison Between 5-Aminosalicylic Acid (5-ASA) and Para-Aminosalicylic Acid (4-PAS) as Potential Protectors Against Mn-Induced Neurotoxicity, Biol Trace Elem Res2013, 152(1):113-6. (I F= 1.923).

Santos, D., Batoreu MC., Aschner, M.,  Marreilha dos Santos, AP.Manganese in Human Parenteral Nutrition: Considerations on Toxicity and Biomonitoring, NeuroToxicology.2013, Ref. No. NEUTOX-D-13-00213. Accepted 12 sept 2013. (3.269).

Santos, DM., Batoréu,MC., Tavares de Almeida,i., L Davis,R., Mateus,ML., Andrade,V., Ramos,R., Torres, E., Aschner, M., Marreilha dos Santos, AP. Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese, Toxicology, 2013, TOX reference:51294 (accepted in 30 august 2013). (IF= 3.681).

Capítulos de livros

Rodrigues AS, Gomes BC, Martins C, Gromicho M, Oliveira NG, Guerreiro PS, Rueff J. “DNA Repair and Resistance to Cancer Therapy”, 2013, Chapter 18, 489-528. New Research Directions in DNA Repair, Intech (


Bettencourt A, Almeida AJ. Poly (methyl methacrylate) Particulate Carriers in Drug Delivery. J Microencapsul 2012; 29(4): 353–367.

Branco V, Canário J, Jun L, Holmgren A, Carvalho, C.. In vivo interaction between mercury compounds and selenium: effects on thioredoxin reductase and glutathione peroxidase. Free Radical Biology & Medicine 2012, 52: 781–793.DOI: 10.1016/j.freeradbiomed.2011.12.002

Capucha, V, Mendes E, Francisco, AP, Perry MJ. “Development of triazene prodrugs or ADEPT strategy: New insights into drug delivery system based on carboxypeptidase G2 activation”. Bioorg&Med Chem Letters 22, 2012, 6903-6908.

Fernandes AS, Costa J, Gaspar J, Rueff J, Cabral MF, Cipriano M, Castro M, Oliveira NG. Development of pyridine-containing macrocyclic copper(II) complexes: potential role in the redox modulation of oxaliplatin toxicity in human breast cells, Free Radical Res, 2012, 46(9): 1157-1166.

Francesco Montalbano, Nuno R. Candeias, Luís F. Veiros, Vânia André, M. Teresa Duarte, Maria R. Bronze, Rui Moreira, Pedro M. P. Gois, Four Component Assembly of Chiral N-B Heterocycles with a Natural Product Like Framework”;Organic Letters 2012, 14 (4), 988-991

Gonçalves S, Fernandes AS, Oliveira NG, Marques J, Costa J, Cabral MF, Miranda J,  Cipriano M, Guerreiro PS, Castro M. Cytotoxic effects of cadmium in mammary epithelial cells: Protective role of the macrocycle [15]pyN5, Food and Chemical Toxicology, 2012, 50, 2180–2187.

Luo X, Pedro L, Milic V, Mulhovo S, Duarte A, Duarte N, Ferreira MJ. Antibacterial benzofuran neolignans and benzophenanthridine alkaloids from the roots of Zanthoxylum capense. Planta Medica  2012, 78: 148-153.

Marreilha dos Santos, A.P., Lucas, Rui L., Andrade, Vanda, Mateus, M. Luísa, Milatovic, Dejan, Aschner, Michael, Batoreu, M. Camila. Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity, Toxicol Appl Pharmacol., 2012, Vol 258 (3); 1.( I F = 4.447) (cit 7).

Martins F, Leitão RE, Ventura MC, Pinheiro L, Nunes N. Densities and refraction indexes for the ternary mixture methanol/1-propanol/acetonitrile. J. Molecular Liq. 2012, 170: 30-36.

Moita ML, Pinheiro LMV, Santos AFS, Lampreia IMS. Volumetric study of (3-ethoxypropan-1-amine + water) mixtures between (283.15 and 303.15) K.  J Chem Eng Data. 2012, 57(8): 2290-2295.

Pingarilho M, Oliveira NG, Martins C, Fernandes AS, Lima JP, Rueff J, Gaspar JF. Genetic polymorphisms in detoxification and DNA repair genes and in vitro susceptibility to glycidamide-induced DNA damage, J Toxicol Environ Health A, 2012, 75: 920-33.

Pinheiro L, Moita ML, Borges S, Reis M, Sousa I, Santos S, Ventura C, Martins F. QSPR modelling of lipophilicity and antitubercular activity of thiobenzanilide derivatives. Chem Listy 2012, 106, s874.

Prigol M, Nogueira CW, Zeni G, Bronze MR, Constantino L. In vitro metabolism of diphenyl diselenide in rat liver fractions. Conjugation with GSH and binding to thiol groups, Chemico-Biological Interactions, 2012, 200(2-3): 65-72.

Reis M, Ferreira R, Serly J, Duarte N, Madureira A, Santos D, Molnár J, Ferreira MJ. Colon adenocarcinoma multidrug resistance reverted by Euphorbia diterpenes: structure-activity relationships and pharmacophore modeling. Anticancer Agents inMedicinalChemistry2012, 12: 1015-1024.

Ribeiro IA, Bronze MR, Castro MF, Ribeiro MHL. Design of selective production of sophorolipids by Rhodotorula bogoriensis through nutritional requirements, Journal of Molecular Recognition, 2012, 25(11): 630-640.

Ribeiro IA, Bronze MR, Castro MF, Ribeiro MHL. Optimization and correlation of HPLC-ELSD and HPLC-MS/MS methods for identification and characterization of sophorolipids, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2012, 899:72-80.

Ribeiro, A. C.; Catarino, S.; Ferreira, R. B. Multiple lectin detection by cell membrane affinity binding. Carbohyd. Res. 2012, 352, 206–210. IF= 2,332

Rijo P, Fernandes AS, Simões F, Pinheiro L. Evaluation of diterpnoids from P. ornatus as potential COX-1 inhibitors. Biomed Biopharm Res. 2012; 9(1):111-118.

Santos D, M. Batoreu MC, Almeida I, Ramos R, Sidoryk-Wegrzynowicz M, Aschner M, Marreilha dos Santos AP. Manganese Alters Rat Brain Amino Acids Levels, Biol Trace Elem Res.,2012. Vol 150, Issue 1, 337-341. (I F= 1.923) DOI: 10.1007/s12011-012-9504-8.

Santos D., Batoreu MC., Aschner M., Marreilha dos Santos AP. Effect of manganese on acetylcholinesterase activity, Toxicology, 2012, vol 298, 61-62. (IF=3.681)

Santos D., Milatovic,D., Andrade, V., Batoreu, M. C., Aschner, M., Marreilha dos Santos, A.P. The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the rat brain, Toxicology, 2012. 26; 292(2-3), 90-8.(IF= 3.681) doi: 10.1016/j.tox.2011.11.017 (11 cit).

Serra AT, Rocha J, Sepodes B, Matias A A, Feliciano RP, Carvalho A, Bronze MR, Duarte CMM, Figueira ME. Evaluation of cardiovascular protective effect of different apple varieties – correlation of response with composition, Food Chemistry, 2012, 135(4): 2378-2386

Tavares L, Fortalezas S, Tyagi M, Barata D, Serra AT, Maria C, Duarte M, Duarte RO, Feliciano RP, Bronze MR, Espirito-Santo MD, Ferreira RB, Santos CN. Bioactive compounds from endemic plants of Southwest Portugal: Inhibition of acetylcholinesterase and radical scavenging activities, Pharmaceutical Biology. 2012, 50(2): 239-246.

Valente A, Bronze MR, Bicho M, Duarte R, Costa HS. Validation and clinical application of an UHPLC method for simultaneous analysis of total homocysteine and cysteine in human plasma, Journal of Separation Sciences, 2012. 35 (24):  3427–3433.

Valente I, Reis M, Duarte N, Serly J, Molnár J, Ferreira MJ. Jatrophane diterpenes from Euphorbia mellifera and their activity as P-glycoprotein modulators on multidrug resistant mouse lymphoma and human colon adenocarcinoma cells. Journal of NaturalProducts2012, 75, 1915 – 1921.

Vasco Branco, Paula Ramos, João Canário, Jun Lu, A. Holmgren, and Cristina Carvalho.2012 Biomarkers of adverse response to mercury: histopathology vs. thioredoxin reductase activity. Journal of Biomedicine and Biotechnology (2012) (accepted on 2012-05-25; published online 2012-07-20) Article ID 359879, 9 pages.                                           

Vilhena C, Bettencourt A. Daptomycin: A Review of Properties, Clinical Use, Drug Delivery and Resistance. Mini Reviews in Medicinal Chemistry, 2012, 12 (3), 202-209.

Wesolowska O, Wisniewski J, Pomianek K, Pohl A, Paprocka M, Dús D, Duarte N, Ferreira MJ, Michalak K. Multidrug resistance reversal and apoptosis induction in human colon cancer cells by some flavonoids present in Citrus plants. Journal of Natural Products 2012, 75, 1915 – 1921.


Bernier N, Costa J, Delgado R, Felix V, Royal G, Tripier R. trans-Methylpyridine cyclen versus cross-bridged trans-methylpyridine cyclen. Synthesis, acid-base and metal complexation studies (metal = Co2+, Cu2+, and Zn2+), Dalton Transactions, 2011, 40(17): 4514-26.

Branco V, Canário J, Holmgren A, Carvalho, C. 2011. Inhibition of the Thioredoxin System in the Brain and Liver of Zebra-Seabreams Exposed to Waterborne Methylmercury. Toxicology and Applied Pharmacology 2011, 251: 95-103.

Carvalho C, Lu J, Zhang X, Arnér E, Holmgren A. Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning. The FASEB Journal 2011, 25: 370-381DOI: 10.1096/fj.10-157594                                                       

Daniel Silva, Mourad Chioua, Abdelouahid Samadi, M Carmo Carreiras, María-Luisa Jimeno, Eduarda Mendes, Cristóbal de los Rios, Alejandro Romero, Mercedes Villaroya, Manuela G. Lopez, José Marco-Contelles. “Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-][1,8]naphthyridine derivatives” Eur J Med Chem, 2011, 1-6.

Fernandes AS, Cabral MF, Costa J, Castro M, Delgado R, Drew MGB, Felix V. Two macrocyclic pentaaza compounds containing pyridine evaluated as novel chelating agents in copper(II) and nickel(II) overload, Journal of Inorganic Biochemistry,2011, 105(3): 410-9.

Galego LR, Da Silva  JP, Almeida VR, Bronze MR, Boas L.V. Preparation of novel distinct highly aromatic liquors using fruit distillates. International Journal of Food Science and Technology, 2011, 46(1), 67-73.

L. Pinheiro, A. Bettencourt, A. Duarte, K. Bettencourt, A. J. Almeida, M. Castro, M. A. Rodrigues, L. Padrela, H. A. Matos. Antibacterial Activity of Minocycline, Tobramycin and Vancomycin Processed by Supercritical Fluids. Proceedings of the 13th European Meeting on Supercritical Fluids – SCFs as product and process solvents in emerging applications. Ed. Institut National Polytechnique de Lorraine. 2011, 1-8. ISBN: 978-2-905267-77-1.

Leite SB, Teixeira AP, Miranda JP, Tostões RM, Clemente JJ, Sousa MF, Carrondo MJ, Alves PM,Toxicol In vitro, 2011, 25(4):825-32.   

Marreilha dos Santos, A.P., Lopes Santos, M., Batoréu, M.C, Aschner, M. Prolactin is a peripheral marker of manganese neurotoxicity, Brain Res., 2011; 1382:282-90. doi: 10.1016/j.brainres.2011.01.047 (cit 9) (IF= 2.739).

Ramos DL, Gaspar JF, Pingarilho M, Gil OM, Fernandes AS, Rueff J, Oliveira NG. Genotoxic effects of doxorubicin in cultured human lymphocytes with different glutathione S-transferase genotypes, Mutat Res, 2011, 724: 28– 34.

Serra AT, Duarte RO, Bronze MR, Duarte, CMM. Identification of bioactive response in traditional cherries from Portugal. Food Chemistry, 2011. 125, 318-325.

Serra AT, Matias AA., Almeida APC,  Bronze MR,  Alves  PM,  Sousa HC , Duarte, CMM Processing cherries (Prunus avium) using supercritical fluid technology. Part 2. Evaluation of SCF extracts as promising natural chemoterapeutical agents, The Journal of Supercritical Fluids, 2011, 55(3), 1007-1013.

Silva S, Boross P, Soares R, Coelho AV, Vilas Boas L, Bronze MR. Characterization of Nüzhenide and Related Secoiridoids in Oleaeuropea L. Seeds Using MALDI TOF Mass Spectrometry, Acta Hort. (ISHS), 2011, 939:403-410.

Tostões RM, Leite SB, Miranda JP, Sousa M, Wang DI, Carrondo MJ, Alves PM.Perfusion of 3D encapsulated hepatocytes: a synergistic effect enhancing long-term functionality in bioreactors, Biotechnol Bioen, 2011, 108(1):41-9.       

Vila-Real H, Alfaia AJ,  Bronze MR, Calado ART, Ribeiro MHL. Enzymatic Synthesis of the Flavone Glucosides, Prunin and Isoquercetin, and the Aglycones, Naringenin and Quercetin, with Selective α-L-Rhamnosidase and β-D-Glucosidase Activities of Naringinase.  Enzyme Research, 2011, Article ID 692618, 11 pages.


Bettencourt A, Florindo HF, Ferreira IFS, Matos A, Monteiro J, Neves C, Lopes P, Castro M, Almeida AJ. Incorporation of Tocopherol Acetate-containing Particles in Acrylic Bone Cement. J Microencapsul,  2010; 27(6):91-101.

Bettencourt A, Neves CB, de Almeida MS, Pinheiro LM, Oliveira SA, Lopes LP, Castro MF. Biodegradation of acrylic based resins: a review. Dent Mater2010; 26(5):e171-180.

Cui X, Delgado R, Costa J, Drew M.G.B., Felix V, Costa PJ. Rigid ferrocenophane and its metal complexes with transition and alkaline-earth metal ions, Polyhedron, 2010, 29, 1697-1705.

Dias T, Bronze MR, Houghton PJ, Mota-Filipe H, Paulo A. The flavonoid-rich fraction of Coreopsis tinctoria promotes glucose tolerance regain through pancreatic function recovery in streptozotocin-induced glucose-intolerant rats. Journal of Ethnopharmacology, 2010, 132(2), 483-490.

Duarte N, Lage H, Ferreira MJ. Phenolic compounds as antineoplasic agents against drug-sensitive and multidrug resistant human cancer cells. Planta Medica2010, 76: 1 – 6.

Feliciano RP, Antunes C, Ramos A, Serra AT, Figueira ME, Duarte CMM, de Carvalho A, Bronze MR. Characterization of traditional and exotic apple varieties from Portugal. Part 1- Nutritional, phytochemical and sensory analysis, Journal of Functional Foods, 2010, 2, 35-45.

Fernandes AS, Gaspar J, Cabral MF, Rueff J, Castro M, Batinic-Haberle I, Costa J, Oliveira NG. Protective role of ortho-substituted Mn(III) N-alkylpyridylporphyrins against the oxidative injury induced by tert-butylhydroperoxide, Free Radical Research, 2010, 44(4):430-40.

Fernandes AS, Serejo J, Gaspar J, Cabral F, Bettencourt AF, Rueff J, Castro M, Costa J, Oliveira NG. Oxidative injury in V79 Chinese hamster cells: protective role of the superoxide dismutase mimetic MnTM-4-PyP, Cell Biology and Toxicology, 2010, 26(2): 91-101.

Ion I, Culetu A, Costa J, Luca C, Ion AC. Polyvinyl chloride-based membranes of 3,7,11-tris (2-pyridylmethyl)-3,7,11,17-tetraazabicyclo 11.3.1 heptadeca-1(17),13,15-triene as a Pb(II)-selective sensor, Desalination, 2010, 259(1-3): 38-43.

Lage H, Duarte N, Ferreira MJ. Antitumor activity of terpenoids against classical and atypical multidrug resistant cancer cells. Phytomedicine2010, 17: 441 – 448.

Marreilha dos Santos AP, Milatovic D, Au C, Yin Z,  Batoreu M CC,  Aschner M. Rat brain endothelial cells are a target of manganese toxicity, Brain Res, 2010; Vol 1326: 152-161.  doi:10.1016/j.brainres.2010.02.016 (cit 17) (IF= 2.739).

Miranda JP, Rodrigues A, Tostões RM, Leite S, Zimmerman H, Carrondo MJ, Alves PM. Extending Hepatocyte Functionality for Drug-Testing Applications Using High-Viscosity Alginate-Encapsulated Three-Dimensional Cultures in Bioreactors.Tissue Eng Part C Methods, 2010, 16(6):1223-32.      

Pinheiro L, Bettencourt A, Duarte A, Bettencourt K, Almeida AJ, Castro M, Padrela L, Rodrigues MA, Matos HA. The Impact of Supercritical Fluids processing on Minocycline Antibacterial Activity. Proceedings of the 12th European Meeting on Supercritical Fluids. 2010, (ISBN: 978-2905267-72-6), 1-6.

Pinheiro L, Matos A, Crespo J, Padrela L, Rodrigues MA, Matos HA, Castro M, Duarte A, Almeida AJ, Bettencourt A. Antibacterial Activity of Tigecycline Micro/Nanoparticles under Supercritical Fluids Conditions. Eur Cells Mater. 2010, (ISSN: 1473-2262), Suppl. 3; 20: 202.

Pinheiro LMV, Ventura C, Moita ML. Application of QSPR-RLM Methodology to Solvatochromic behavior of Quinoline in Binary Solvent Mixtures. J Molecular Liq. 2010; 154 (2-3): 102-110.

Pusztai R, Abrantes M, Sherly J, Duarte N, Molnár J, Ferreira MJ. Antitumor-promoting activity of lignans: inhibition of human cytomegalovirus IE gene expression. Anticancer Research2010, 30: 451 – 454.

Rodrigues SM, Vale P, Chaveca T, Laires A, Rueff J, Oliveira NG. Naturally contaminated shellfish extracts samples: quantification of diarrhetic poisoning toxins in unhydrolysed and hydrolised extracts and cytotoxicity assessment, J Appl Toxicol, 2010, 30: 699-707.

Serra AT, Matias AA,  Frade R, Duarte RO, Feliciano R,  Bronze MR, de Carvalho A, Duarte, CMM. Characterization of traditional and exotic apple varieties from Portugal. Part 2- Antioxidant and antiproliferative activities, Journal of Functional Foods, 2010, 2, 46-53.

Serra AT, Matias AA, Almeida APC, Bronze MR, Alves PM, Sousa HC, Duarte, CMM. Processing cherries (Prunus avium) using supercritical fluid technology. Part 1. Recovery of extract fractions rich in bioactive compounds, The Journal of Supercritical Fluids, 2010, 55(1), 184-191.

Serra, H, Bronze MR, Simplício AL. Simultaneous determination of clopidogrel and its carboxylic acid metabolite by capillary electrophoresis, Journal of Chromatography B, 2010, 878, 19, 1480-1486.

Silva DES, Albuquerque LMPC, Calado ART, Pinheiro LMV, Segurado MAP. Partial Molar Volumes of Butyltriethylammonium Iodide in Single Non-Aqueous Solvents at 298.15 K. J Chem Eng Data. 2010; 55(3): 1100-1104.

Silva S, Gomes L., Leitão F, Bronze MR, Coelho AV, Boas LV. Secoiridoids in olive seed: characterization of nuzhenide and 11-methyl oleosides by liquid chromatography with diode array and mass spectrometry. Grasas Y Aceites, 2010, 61(2), 157-164.

Tavares L, Carrilho D, Tyagi M, Barata D, Serra AT, Duarte, CMM, Duarte RO, Feliciano R, Bronze MR, Chicau P, Espírito-Santo MD, Ferreira RB, Santos CN. Trace of molecules correlated with the antioxidant activity presented by Macaronesia traditional medicinal plants, Molecules, 2010, 15, 2576-2592.

Wesolowska O, Wisniewski J, Pohl A, Paprocka M, Duarte N, Ferreira MJ, Dús D, Michalak K. Stilbenes as multidrug resistance modulators and apoptosis inducers in human adenocarcinoma cells. Anticancer Research 2010, 30: 4587 – 4594.


Duarte N, Ramalhete C, Varga A, Molnár J, Ferreira MJ. Multidrug resistance modulation and apoptosis induction of cancer cells by terpenic compounds isolated from Euphorbia species. Anticancer Research2009, 29: 4467 – 4472.

Feliciano RP, Bravo MN, Pires MM, Serra AT, Duarte CMM, Boas LV, Luís, Bronze MR. Phenolic Content and Antioxidant Activity of Moscatel Dessert Wines from the Setúbal Region in Portugal, Food Anal. Methods, 2009, 2(2), 149-161.

Leticia Bignotto, Joao Rocha, Bruno Sepodes, Maria Eduardo-Figueira, Rui Pinto, Marco Chaud, Joao Carvalho, Heitor Moreno Junior, Helder Mota-Filipe, Anti-inflammatory effect of lycopene on carrageenan-induced paw edema and hepatic ischemia-reperfusion in the rat, British Journal of Nutrition. 2009, 102(1):126-33.

M. Jesus Perry, Eduarda Mendes, Ana Luísa Simplício, Ana Coelho, Ricardo V. Soares, Jim Iley, Rui Moreira and Ana Paula Francisco “Dopamine- and tyramine-based derivatives of triazenes. Activation by tyrosinase and implications for prodrug design”. Eur J Med Chem, 2009, 44, 3228-3234.

Maria Inês Amaro, João Rocha, Maria Eduardo-Figueira, Helder Mota-Filipe, Bruno Sepodes, Maria H. Ribeiro. Anti-inflammatory activity of naringin and the biosynthesid naringenin by naringinase immobilized in microstructured materials in a model of DSS-induced colitis in mice, Food Research International, 2009, 42(8): 1010-1017.

Miranda JP, Leite SB, Muller-Vieira U, Carrondo MJT, Alves PM. Towards extended functional hepatocyte in vitro culture, Tissue Engineering PartC Methods, 2009, 15(2):17-67.  

Oliveira NG, Pingarilho M, Martins C, Fernandes AS, Vaz S, Martins V, Rueff J, Gaspar JF. Cytotoxicity and chromosomal aberrations induced by acrylamide in V79 cells: Role of glutathione modulators, Mutat Res, 2009, 676, 87-92.

Ruiz-Rodriguez A, Najdanovic-Visak V, Visak Z, Bronze MR, Antunes C, da Ponte, MN. High-pressure phase behaviour of binary (CO2 + nicotine) and ternary (CO2 + nicotine plus solanesol) mixtures. Fluid Phase equilibria, 2009, 282(1), 58-64.

Silva S., Rosa NF, Ferreira AE, Boas LV, Bronze MR. Rapid Determination of α-tocopherol in vegetable oils by Fourier transform infrared spectroscopy, Food Anal. Methods, 2009, 2(2), 120127.

Spengler G, Ramalhete C, Martins M, Martins A, Serly J, Viveiros M, Molnár J, Duarte N, Mulhovo S, Ferreira MJ, Amaral L. Evaluation of cucurbitane-type triterpenoids from Momordica balsamina on P-glycoprotein (ABCB1) by flow cytometry and real-time fluorometry. Anticancer Research2009, 29:  3989 – 3994.

Teisseyre A, Duarte N, Ferreira MJ, Michalak K. Influence of the multidrug transporter inhibitors on the activity of Kv1.3 on voltage gated potassium channels. Journal of Physiology and Pharmacoloy 2009, 60: 69 – 76.


Abrantes M, Mil-Homens T, Duarte N, Lopes D, Cravo P, Madureira MC, Ferreira MJ. Antiplasmodial activity of lignans and extracts from Pycnanthus angolensis. Planta Medica2008, 74: 1408 – 1412.

Aschner M, dos Santos APM, Erikson KM, Zheng W. Manganese transport into the brain: putative mechanisms, Metal Ions Biol Med, 2008; 10:695-700.

C.M.L.Carvalho, A.I.N.M.Matos, M.L.Mateus, A.P.M.Santos and M.C.C.Batoréu 2008. High-fish consumption and risk prevention: Exposure assessment to methylmercury in Portugal. Journal of Toxicology and Environmental Health, Part A, 2008, 71: 1279-1288. 

Carvalho CML, Matos AINM, Mateus ML, Santos APM, Batoreu MCC. High fish consumption and Risk Prevention: Assessment of Exposure to Methylmercury in Portugal, J Toxicol Environ Health, Part A, 2008, 71:18, 1279-1288.

Carvalho, CML, Chew, E-H, Hashemy, SI, Lu, J, Holmgren, A.  2008. Inhibition of Human Thioredoxin System: a molecular mechanism of mercury toxicity. Journal of Biological Chemistry, 2008, 283: 11913-11923. 

Duarte N, Járdánházy A, Molnár J, Ferreira MJ. Synergistic interaction between p-glycoprotein modulators and epirubicine on resistant cancer cells. Bioorganic and Medicinal Chemistry2008, 16: 9323 – 9330.

Duarte N, Kayser O, Abreu P, Ferreira MJ. Antileishmanial activity of piceatannol isolated from Euphorbia lagascae seeds. Phytotherapy Research2008, 22: 455 – 457.

Duarte N, Lage H, Ferreira MJ. Three new jatrophane polyesters and antiproliferative constituents from Euphorbia tuckeyana. Planta Medica 2008, 74: 61 – 68.

Lubal P, Albrecht-Gary AM, Blanc S, Costa J, Delgado R. Kinetic study of dissociation of a copper(II) complex of a 14-membered tetraaza-macrocyclic ligand containing pyridine and pendant N-carboxymethyl arms, Collection of Czechoslovak Chemical Communications, 2008, 73(2): 258-74.

Márcia Reto, Maria Eduardo Figueira, Helder Mota Filipe, Cristina M. M. Almeida. Teor de Fluoretos em Infusões de Chá Verde (Camellia sinensis), Química Nova, 2008, 31(2), 317-320.

Marreilha dos Santos AP, Santos D, Au C, Milatovic D, Aschner M,Batoréu MCC. Anti-oxidants prevent the cytotoxicity of Mn in RBE4 Cells, Brain Res, 2008, 1236C:200-205 (24 cit). doi: 10.1016/j.brainres.2008.07.125 (IF= 2.739).

Nunes N,  Martins F, Pinheiro L, Leitão RE.  Volumic properties for the ternary mixture methanol-formamide-acetonitrile. Proceedings of the 10th International Chemical and Biological Engineering Conference (ISBN: 978-972-97810-3-2), 2008; 1-6.

Yin Z, Aschner J, dos Santos AP, Aschner M. Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures, Mol Brain Res, 2008, 1203:1-11 (cit 45)(IF= 2.538).

Capítulos de livros

Ferreira MJ, Duarte N, Lage H, Molnár J. Reversal of multidrug resistance by macrocyclic and polycyclic diterpenoids from Euphorbia species. In Govil JN and Kaushik G (Editors), Recent Progress in Medicinal Plants: Ethnomedicine and Therapeutic Validation, Volume 32, Chapter 8, pp 193 – 213. Studium Press LLC, 2012. ISBN: 1-933699-22-1.

Ferreira MJ, Duarte N, Michalak K, Varga A, Molnár J. Piceatannol, an antitumor compound from Euphorbia lagascae seeds. In Preedy VR, Watson RR, Patel VB (Editors), Nuts & Seeds in Health and Disease Prevention (1st ed.), Chapter 54, pp 453-460. Academic Press, 2011. ISBN: 9780123756886.

Mendes E., Perry M.J., Francisco A.P. “The synthetic utility of triazenes in heterocycle synthesis”, Heterocyclic Targets in Advanced Organic Synthesis, 2011, Transworld Research Network, 37/661 (2), Trivandrum-695 023, Kerala, India.

Mingwei Ni, M., Li, X., Marreilha dos Santos, AP., Farina, M., Rocha, JBT., Soldin, OP., Rongzhu, L., Aschner, M. Reproductive and Developmental Toxicology, editor Ramesh Gupta, 2011, Elsevier, section 7, cap 35 (Metals). (Capitulo Livro) (8 autores).

Francisco A.P., Perry M.J., Moreira R., Mendes E. “Alkylating Agents” in Anticancer Therapeutics, ed. Sotiris Missailidis, John Wiley&Sons, Ltd, 2008, chapter 9, 133-157.

Santos JM, Filipe E, Filipe M, Teixeira M, Cipriano M, Barcia R, Cruz P, Mosqueira D, Nascimento DS, Pinto-do-O P, Cruz H, Castro M, Miranda JP. 2013. Method for priming umbilical cord tissue-derived mesenchymal stromal cells (UC-MSCs) towards a higher therapeutic potential and applications thereof. Portugal: ECBio; [INPI, Provisional Patent: 107148].

Rodrigues MAJ, Padrela LMB, Matos HAS, Gomes de Azevedo EJS, Pinheiro LMV, Bettencourt AF, Castro MLSDF, Almeida AJLN, Duarte MACSC. Thermo-resistant Crystalline Minocycline produced by Recrystallization with Carbon Dioxide. PT Patent 106063 D, December 19, (2013-06-19).

Rodrigues M, Padrela L, Matos H, Gomes de Azevedo E,  Pinheiro L, Bettencourt A,  Castro M, Almeida A, Duarte MA. Minociclina cristalina termorresistente produzida por recristalização com dióxido de carbono. Número de pedido PT Patente 20111000096911 (2011-12-19). Número de Publicação PT Patent 106063 (2013-06-19).

Rodrigues M, Padrela L, Matos H, Gomes de Azevedo E,  Pinheiro L, Bettencourt A,  Castro M, Almeida A, Duarte MA. Crystalline Minocycline Thermo-resistant obtained by recrystallization with carbon dioxide. Patent International Application Number PCT/PT2012/00005 (Nov 2012). Patent Publication number WO2013/095169 A1 (2013-06-27