2016 | 2015 | 2014 | 2013 | 2012

  • 2017

Capítulos de livros/Book chapters

Helena F Florindo, João A Lopes, Liana C Silva, L Corvo, MB Martins, R Gaspar (2017). Regulatory development of Nanotechnology-based vaccines. in Micro and Nanotechnology in Vaccine Development, edited by Dr Mariusz Skwarczynski and Professor Istvan Toth, Elsevier ISBN: 978-0-323-39981-4;

Laure Lambricht, Carina Peres, Helena F Florindo, Véronique Préat, Gaëlle Vandermeulen. Polymer-based nanoparticles as modern vaccine delivery systems (2017). in Micro and Nanotechnology in Vaccine Development, edited by Dr Mariusz Skwarczynski and Professor Istvan Toth, Elsevier

Praça, F.S., Marinho, H.S., Martins, M.B.F., Gaspar, R.S., Corvo, M.L., Medina, W.  Current aspects of breast cancer therapy and diagnosis based on a nanocarrier approach, in Nanostructures for Cancer Therapy Alexandru Mihai Grumezescu and Anton Ficai, ed. Chapter 27. Elsevier. 2017 (in press)

Ana R.P. Varela, André Sá Couto, Alexander Fedorov, Anthony H. Futerman, Manuel Prieto, Liana C. Silva* (2016) “Glucosylceramide reorganizes cholesterol-containing domains in a fluid phospholipid membrane”, Biophys J, 110, 612-622 doi: 10.1016/j.bpj.2015.12.019

Ascenso A., Pedrosa T., Pinho S., Pinho F., Oliveira J.M.P. , Marques H.C. , Oliveira H., Simões S., Santos C. The Effect of Lycopene Pre-Exposure on UV-B Irradiated Human Keratinocytes. Oxidative Medicine and Cellular Longevity 2016. doi:10.1155/2016/8214631.

Beloqui A., Solinís MA, Rodríguez-Gascón A, Almeida AJ, Préat V (2016). Nanostructured lipid carriers: promising drug delivery systems for future clinics. Nanomed-Nanotechnol. 12: 143–161.

Bettencourt A, Feliz MA, Gonçalves LM, Neves CB (2016). An acrylic reline resin loaded with chlorhexidine:Insights on drug release. Rev Port Estomatol Med Dent Cir Maxilofac, Revista Portuguesa de Estomatologia 05/2016 (DOI:10.1016/j.rpemd.2016.04.001)

Bicho J, Marto J, Salgado A, Raposo S, Simões S, Ribeiro H (2016). Lipid nanocarriers for ketoconazole topical delivery. Gavin J Dermatol Res Ther  2016: 7-13.

Caetano LA, Almeida AJ, Gonçalves LMD (2016). Effect of experimental parameters on alginate/chitosan microparticles for BCG encapsulation. Mar Drugs. 14: 90; doi:10.3390/md14050090.

Calado S, Eleutério C, Mendes E, Rocha MJ, Francisco AP, Gaspar MM (2016) Nanoformulations of a triazene analogue with specific affinity to human melanoma, J Nanosci Adv Tech, 2016, 1(4): 1-9.

Carrasco MP, Machado M, Gonçalves L, Sharma M, Gut J, Góis A, Lukens AK, Wirth DF, André V, Duarte MT, Guedes RC, Santos DJ, Rosenthal PhJ, Mazitzschek R, Prudêncio M, Moreira R (2016). Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites. ChemMedChem. (DOI: 10.1002/cmdc.201600327)

Corvo, M. L., Mendo, A. S., Figueiredo, S., Gaspar, R., Larguinho, M., Guedes da Silva, M. F., Baptista, P. V. & Fernandes, A. R. 2016. Liposomes as Delivery System of a Sn(IV) Complex for Cancer Therapy. Pharmaceutical Research,  1-8. doi:10.1007/s11095-016-1876-6.

Cláudia A. Teixeira dos Santos, Ricardo N.M.J. Páscoa, Patrícia A.L.S. Porto, António L. Cerdeira, João A. Lopes (2016) Application of Fourier-transform infrared spectroscopy for the determination of chloride and sulfate in wines, LWT – Food Sci. Technol., 67, 181–186 [doi: 10.1016/j.lwt.2015.11.050]

Duarte I, Corvo ML, Serodio P, Vicente J, Pinto JF, Temtem M, 2016 Production of Nano-Solid Dispersions Using a Novel Solvent-Controlled Precipitation Process – Benchmarking Their in Vivo Performance With an Amorphous Micro-Sized Solid Dispersion Produced by Spray Drying. Eur J Pharm Sci;93:203-214

Durán-Lobato M, Martín-Banderas L, Lopes R, Gonçalves L, Fernández-Arévalo M, Almeida AJ (2016). Lipid nanoparticles as an oral delivery platform for cannabinoids. Drug Dev Ind Pharm. 42: 190-198.

Fábio M.F. Santos, João N. Rosa, Nuno R. Candeias, Cátia P. Carvalho, Ana I. Matos, Ana E. Ventura, Helena F. Florindo, Liana C. Silva, Uwe Pischel, Pedro M.P. Góis (2016) “A Three-Component Assembly Pomoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes)”, Chem Eur J, 22, 1631-1637 doi: 10.1002/chem.201503943

Fonte P, Roque Lino P, Seabra V, Almeida AJ, Reis S, Sarmento B (2016). Annealing as a tool for the optimization of lyophilization and ensuring of the stability of protein-loaded PLGA nanoparticles.  Int J Pharm. 503:163-173.

Gaspar DP, Faria V, Gonçalves LM, Taboada P, Remuñán-López C, Almeida AJ (2016). Rifabutin-loaded solid lipid nanoparticles for inhaled antitubercular therapy: physicochemical and in vitro studies. Int J Pharm. 497: 199–209.

Gonçalves LMD, Maestrelli F, Mannelli LC, Ghelardini C, Almeida AJ, Mura P. (2016). Development of solid lipid nanoparticles as carriers for improving oral bioavailability of glibenclamide. Eur J Pharm Biopharm. 102: 41-50.

João R. Santos, Miguel Lopo, António O.S.S. Rangel, João A. Lopes* (2016) Exploiting near infrared spectroscopy as an analytical tool for on-line monitoring of acidity during coffee roasting, Food Cont., 60, 408-415 [doi:10.1016/j.foodcont.2015.08.007]

J.M. G. Sarraguça, C. Lima, F. Machado, J.A. Lopes*, A. Almeida, L. Fernandes, T. Magalhães, A. Santos (2016) A FT-NIR spectroscopy methodology for estimating the firing distance based on the direct analysis of the bullet impact surface, Analyst, 141, 4410-4416 [doi:10.1039/C6AN00247A]

J.R. Santos, O. Viegas, R.N.M.J. Páscoa*, I.M.P.L.V.O. Ferreira, A.O.S.S. Rangel, J.A. Lopes (2016) In-line monitoring of the coffee roasting process with near infrared spectroscopy: measurement of sucrose and colour, Food Chem., 208, 103-110 [doi: 10.1016/j.foodchem.2016.03.114]

Lopes RM, Pereira J, Esteves A, Gaspar MM, Carvalheiro M, Eleutério CV, Gonçalves LMD, Jiménez-Ruiz A, Almeida AJ, Cruz MEM (2016). Lipid-based nanoformulations of trifluralin analogs in the management of Leishmania infantum infections. Nanomedicine (Lond), 11: 153-170.

Luís M. Magalhães, Sandia Machado, Marcela A. Segundo, João A. Lopes, Ricardo, N.M.J. Páscoa* (2016) Rapid assessment of bioactive phenolics and methylxanthines in spent coffee grounds by FT-NIR spectroscopy, Talanta, 147, 460–467 [doi:10.1016/j.talanta.2015.10.022]

Mafalda Cruz Sarraguça, Rita Matias, Raquel Figueiredo, Paulo Roberto S. Ribeiro, Ana T. Martins, João Almeida Lopes*, Near infrared spectroscopy to monitor drug release in-situ during dissolution tests, Int. J. Pharm. (accepted on the 2nd of september 2016)

Matos, J.C., Avelar, I., Martins, M.B.F., Gonçalves, C. Greensilica® vectors for Smart Textiles. Carbohydrate Polymers, in press. http:/

Marçal, R., Carrola, J., Jarak, I., Corvo, M. L., Duarte, I. F. & Pereira, M. L. 2016. Microscopic Studies of Liver and Kidney in Mice Exposed to Silver Nanoparticles. Microscopy and Microanalysis, 22, 18-19. DOI: 10.1017/S1431927616000283.

Marcel de Matas*, Thomas De Beer, Staffan Folestad, Jarkko Ketolainen, Hans Lindén, João Almeida Lopes, Wim Oostra,  Marco Weimerh, Per Ohrngren, Jukka Rantanen (2016) Strategic Framework for Education and Training in Quality by Design (QbD) and Process Analytical Technology (PAT), Eur. J. Pharm. Sci., 90, 2-7 [doi:10.1016/j.ejps.2016.04.024]

Marques CF, Matos AC, Ribeiro IAC, Gonçalves LM, Bettencourt A, Ferreira JMF (2016). Insights on the properties of levofloxacin-adsorbed Sr- and Mg-doped calcium phosphate powders. J Mater Sci Mater Med. 27(7):123.

Marto J, Vitor C, Guerreiro A, Severino C, Eleutério C, Ascenso A, Simões S (2016). Ethosomes for enhanced skin delivery of griseofulvin Colloids Surf B Biointerfaces 146: 616-623.

Marto J, Ascenso A, Gonçalves LM, Gouveia LF, Manteigas P, Eleutério C, Chiari-Andréo BG, Isaac V, Pinto P, Oliveira E, Almeida AJ, Ribeiro HM (2016). Melatonin-based Pickering emulsion for skin’s photoprotection. Drug Deliv. 23: 1594-1607.

Marto J, Ascenso A, Simões S, Almeida AJ, Ribeiro HM (2016). Pickering emulsions: challenges and opportunities in topical delivery. Exp Opin Drug Deliv. In press.

Marto J, Gouveia LF, Chiari BG, Paiva A, Isaac V, Pinto P, Simões P, Almeida AJ, Ribeiro HM (2016). The green generation of sunscreens: Using coffee industrial sub-products. Ind Crops Prod. 80: 93–100.

Marto J, Gouveia LF, Gonçalves LM, Gaspar DP, Pinto P, Carvalho FA, Oliveira E, Ribeiro HM, Almeida AJ (2016). A Quality by Design (QbD) approach on starch-based nanocapsules: a promising platform for topical drug delivery. Colloid Surface B. 143: 177-185.

Marto J, Gouveia LF, Gonçalves LM, Chiari-Andréo B, Isaac V, Pinto P, Oliveira E, Almeida AJ, Ribeiro H (2016). Design of novel starch-based Pickering emulsions as platforms for skin photoprotection. J Photochem Photobiol B. 162: 56-64.

Menezes AC, Campos PM, Euletério C, Simões S, Praça FSG, Bentley MVLB, Ascenso A (2016). Development and characterization of novel 1-(1-naphthyl)piperazine-loaded lipid vesicles for prevention of UV-induced skin inflammation. Eur J Pharm Biopharm. 104:101-109

M. Lopo, R.N.M.J. Páscoa, A.R. Graça, J.A. Lopes (2016) Classification of vineyards soils using portable and benchtop near infrared spectrometers: a comparative study, Soil Sci. Soc. Am., 80(3), 652-661[doi:10.2136/sssaj2015.09.0324]

Nave M, Castro RE, Cecília M. P. Rodrigues CMP, Casini A, Soveral G, Gaspar MM (2016) Nanoformulations of a potent copper-based aquaporin inhibitor with cytotoxic effect against cancer cells, Nanomedicine UK, 2016, 11 (4): 1817-1830.

Peeters E., Silva A.F.T., Toiviainen M., Van Renterghem J., Vercruysse J., Juuti M., Lopes J.A., De Beer T.,  Vervaet C.,  Remon J-P. (2016) Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy, Asian J. Pharm. Sci., 11(4), 547-558 [doi:10.1016/j.ajps.2016.04.004]

Raposo, L. R., Roma-Rodrigues, C., Faisca, P., Alves, M., Henriques, J., Carvalheiro, M. C., Corvo, M. L., Baptista, P. V., Pombeiro, A. J. & Fernandes, A. R. (2016). Immortalization and characterization of a new canine mammary tumour cell line FR37-CMT. Veterinary and Comparative Oncology , in press. DOI: 10.1111/vco.12235

Ribeiro CJA, Espadinha M, Machado M, Gut J, Gonçalves LM, Rosenthal PhJ, Prudêncio M, Moreira R, Santos MMM (2016). Novel squaramides with in vitro liver stage antiplasmodial activity. Bioorg. Med. Chem. 24(8), 1786-1792.

Ruivo EFP, Gonçalves LM, Carvalho LAR, Guedes RC, Hofbauer St, Brito JA, Archer M, Moreira R, Lucas SD (2016). Clickable `4-oxo-β-lactam-based probe for human neutrophil elastase related proteomes. ChemMedChem. (DOI:10.1002/cmdc.201600258)

R.N.M.J. Páscoa, M. Lopo, C.A. Teixeira dos Santos, A.R. Graça, J.A. Lopes* (2016) Exploratory study on vineyards soil mapping by visible/near-infrared spectroscopy of grapevine leaves, Comput. Elect. Agric., 127, 15-25 [doi:10.1016/j.compag.2016.05.014]

Sarraguça M.C., Paisana M., Pinto J., Lopes J.A.. (2016) Real-time monitoring of cocrystallization processes by solvent evaporation: a near infrared study, Eur. J. Pharm. Sci., 90, 76-84  [doi:10.1016/j.ejps.2015.12.025]

Silva FC, Marto J, Salgado A, Machado P, Silva A, Almeida AJ (2016). Nystatin and lidocaine pastilles for the local treatment of oral mucositis. Pharm Dev Technol. Accepted.

Simões S, Carvalheiro M, Gaspar MM. (2016) Lipid-Based Nanocarriers for Cutaneous Leishmaniais and Buruli Ulcer Management, Current Pharmaceutical Design, 22.

Simões S., Mendes T., Eleutério C., Pinto P., Ascenso A.. Development and Characterization of a Novel Vesicular System for Topical Delivery: an Opportunity for Dimethylsulfoxide. Med chem (Los Angeles) 6: 250-256. doi:10.4172/2161-0444.1000354


Capítulos de livros/Book chapters

Adeoye, O.; Figueiredo, A and Cabral-Marques, H. Cyclodextrins and Skin Disorders: Therapeutic and Cosmetic Applications In: A Andreia (ed), Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Pan Stanford Publishing Pte Ltd., Singapore (ISBN: 9789814745581)., 2016. (in press)

Ana E. Ventura, Tânia Santos, Ana. C. Carreira, Nuno M. Martinho, J. Conniot, Ana R. Varela, Rogério Gaspar, Helena F. Florindo, Liana C. Silva (2016) “Drugs, delivery systems and membrane organization in model and cell membranes.” In: Angel Catala (Eds) “Membrane organization and lipid rafts in the cell and artificial membranes”, Chapter 4, Nova Science Publishers Inc, New York, ISBN: 978-1-63484-589-2

Corvo, M.L., Marinho, H.S., Martins, M.B.F. Nanomedicines as a strategy for the therapeutic use of superoxide dismutases, in Superoxide Dismutase (SOD): Sources, Therapeutic Uses and Health Benefits. Nancy H. Phillips, ed., Chapter 4,  NY: Nova Publishers.20016 (in press)

Gaspar D, Peres C, Florindo H, Almeida AJ (2016). Mucosal immunization using polyester-based particulate systems. In: Ravi Kumar MNV (ed), Handbook of Polyester Drug Delivery Systems. Pan Stanford Publishing Pte. Ltd., Singapore (ISBN: 978-9814669658), pp. 521-561.

Mafalda C. Sarraguça, Ricardo N.M.J. Páscoa, Miguel Lopo, Jorge M.G. Sarraguça, João A. Lopes*.(2016) Chapter 8:  Bioactive compounds in coffee as health promotors, 180-220, in Natural bioactive compounds from fruits and vegetables as health promoters, Vol. 2, Edited by Luís Silva and Branca Silva, Bentham Science Publishers, 2016 (ISBN: 978-1-68108-240-0)

Marto J, Jorge I, Almeida AJ, Ribeiro HM (2016). Novel starch-derived topical delivery systems. In: Ascenso A, Ribeiro, H, Sinões S (eds), Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Pan Stanford Publishing Pte Ltd., Singapore (ISBN: 9789814745581). In Press.

Paulo Salústio, Graça Miguel, and Helena Cabral-Marques. Chapter 40. Molecular (Cyclodextrin) Encapsulation of Volatiles and Essential Oils. In: Munmaya Mishra, ed. Handbook of Encapsulation and Controlled Release. CRC Press, Taylor & Francis Group, 2016. pp. 867-906. Available from:

Vitorino C, Almeida AJ (2016). Solid lipid nanoparticles (SLN) and nanostructured lipid carries (NLC) as topical delivery systems for antioxidants. In: Ascenso A, Ribeiro, H, Sinões S (eds), Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Pan Stanford Publishing Pte Ltd., Singapore (ISBN: 9789814745581). In Press.



Ana C. Carreira, Ana E. Ventura, Ana R.P. Varela, Liana C. Silva*, (2015) “Tackling the biophysical properties of sphingolipids to decipher their biological roles”, Biol Chem, 396 (6-7): 597-609, doi: 10.1515/hsz-2014-0283

Areias LRP, Ruivo EFP, Gonçalves LM, Duarte TM, André V, Moreira R., Lucas SD, Guedes RC (2015). A unified approach toward rational design of nanomolar human neutrophil elastase inhibitors. RSC Adv., 5: 51717-51721

Ascenso A., Raposo S., Batista C., Cardoso P., Mendes T., Praça F.G., Bentley M.V.LB., Simões S.. Development, Characterization and Skin Delivery Studies of Related Ultradeformable Vesicles: Transfersomes, Ethosomes and Transethosomes. International Journal of Nanomedicine 2015 (10): 5837–5851

Bárcia RN, Santos JM, Filipe M, Teixeira M, Martins JP, Almeida J, Água-Doce A, Almeida SCP, Varela A, Pohl S, Dittmar KEJ, Calado S, Simões SI, Gaspar MM, Cruz MEM, Lindenmaier W, Graça L, Cruz H, Cruz PE. (2015) What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?, Stem Cells International, 1-14,

Cámara-Martos, F.*, Lopes, J. A., Moreno-Rojas, R. and Pérez-Rodríguez, F. (2015), Detection and quantification of Escherichia coli and Pseudomonas aeruginosa in cow milk by near-infrared spectroscopy. Int. J. Dairy Technol., 68(3), 357-365 [doi: 10.1111/1471-0307.12191]

Carvalheiro, M., Esteves, M.A., Santos-Mateus, D., Lopes, R.M., Rodrigues, M.A., Eleutério, C.V. Scoulica, E., Santos-Gomes, G., Cruz, M.E.M. (2015). Hemisynthetic trifluralin analogues incorporated in liposomes for the treatment of leishmanial infections. Eur. J. Pharma. Biopharm., 93, 346–352.

Corvo, M.L., Marinho, H.S., Marcelino, P., Lopes, R., Vale, C.A., Marques, C.R., Martins, L.C.D., Laverman, P., Storm. G., Martins, M.B.F. (2015) Superoxide Dismutase Enzymosomes: Carrier Capacity Optimization, in Vivo Behaviour and Therapeutic Activity. Pharmaceutical Research. 32(1): 91-102. DOI 10.1007/s11095-014-1447-7.

Cristina Quintelas, Daniela P. Mesquita, João A. Lopes, Eugénio C. Ferreira, Clara Sousa* (2015) Near-infrared spectroscopy for the detection and quantification of bacterial contaminations in pharmaceutical products, Int. J. Pharm., 492(1-2), 199-206 [doi:10.1016/j.ijpharm.2015.07.005]

Durán-Lobato M, Martín-Banderas L, Gonçalves L, Fernández-Arévalo M, Almeida AJ (2015). Comparative study of chitosan- and PEG-coated lipid and polymeric nanoparticles as oral delivery systems for cannabinoids. J Nanopart Res. 17: 61. DOI 10.1007/s11051-015-2875-y.

Eva Zupančič, Carina Peres, Ana I Matos, João N Moreira, Rogério S Gaspar, Helena F Florindo. Translational Peptide-associated Nanosystems: Promising Role as Cancer Vaccines. Cur Topics Med Chem. 2015; 16(3): 291-313 PMID: 26126909

Ferreira IS, Bettencourt A, Almeida AJ (2015). Nanoparticulate platforms for targeting bone infections: meeting a major therapeutic challenge. Nanomedicine (Lond). 10: 3147-3166.

Gaspar MM, Calado S, Pereira J, Ferronha H; Correia I, Castro H, Tomás AM, Cruz MEM  (2015) Targeted Delivery of Paromomycin in Murine Infectious Diseases Through Association to Nano Lipid Systems, Nanomedicine: Nanotechnology, Biology, and Medicine, 2015, 11(7): 1851-1860. Doi: 10.1016/j.nano.20115.06.008.

Joana M Silva, Eva Zupancic, Gaëlle Vandermeulen, Vanessa Oliveira, Ana Salgado, Mafalda Videira, Manuela Gaspar, Luís Graça, Véronique Préat*, Helena F Florindo*. In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model. J Control Release 2015; 198C; 91-103. IF=7.768 DOI: 10.1016/j.jconrel.2014.11.033

Joana Mogrão, Catarina A da Costa, R Gaspar, Helena F Florindo. Dendritic cell in vivo modulation by nanotechnology-based immunotherapeutic strategies. J Biomed Nanotechnol 2015; 11: 1-30

Lucas SD, Carrasco MP, Gonçalves LM, Moreira R, Guedes R (2015). Discovery of C-shaped aurone human neutrophil elastase inhibitors. Med. Chem. Commun. 6(8): 1508-1512

Madalena V. Cruz, Mafalda Cruz Sarraguça, Filomena Freitas, João Almeida Lopes*, Maria A. M. Reis (2015) Online monitoring of P(3HB) produced from used cooking oil with near-infrared spectroscopy, J. Biotechnol., 194, 1-9 [doi: 10.1016/j.jbiotec.2014.11.022]

Mafalda C. Sarraguça, Paulo R. S. Ribeiro, Adenilson O. dos Santos, João A. Lopes* (2015) Batch statistical process monitoring approach to a cocrystallization process, J. Pharm. Sci., 104(12),4099-4108 [doi: 10.1002/jps.24623]

Mancini G, Lopes R, Clemente P, Raposo S, Gonçalves LMD, Bica A, Ribeiro HM, Almeida AJ (2015).  Lecithin and parabens play a crucial role in tripalmitin-based lipid nanoparticle stabilization throughout moist heat sterilization and freeze-drying. Eur J Lip Sci Tech. 117: 1947-1959.

Matos AC, Ribeiro IAC, Guedes RC, Pinto R, Vaz MA, Gonçalves LM, Almeida AJ, Bettencourt AF (2015). Key-Properties outlook of levofloxacin-loaded acrylic bone cement for improved antibiotic delivery. Int J Pharm. 485: 317–328.

Matos AC, Marques CF, Pinto RV, Ribeiro IC, Gonçalves LMD, Vaz MA, Ferreira JM, Almeida AJ, Bettencourt A (2015). Novel doped calcium phosphate-PMMA bone cement composites as levofloxacin delivery systems: exploring the concept.  Int J Pharm. 490: 200-208.

Marto J, Gouveia L, Jorge IM, Duarte A, Gonçalves LM, Silva SMC, Antunes FE, Pais AACC, Oliveira E, Almeida AJ, Ribeiro HM (2015). Starch-based Pickering emulsions for topical drug delivery: a QbD approach. Colloid Surface B 135: 183-192.

Menezes A.C., Raposo S., Simões S., Ribeiro H., Oliveira H., Ascenso A.. Prevention of Photocarcinogenesis by Agonists of 5-HT1A and Antagonists of 5-HT2A Receptors. Molecular Neurobiology, 2015 DOI 10.1007/s12035-014-9068-z

Raposo S, Tavares R, Gonçalves L, Simões S, Urbano M, Ribeiro HM (2015). Mometasone Furoate – loaded cold processed oil-in-water emulsions: in vitro and in vivo studies. Drug Delivery, 22(4):562-572 (DOI: 10.3109/10717544.2013.871086) IF: 2,015

Ricardo N.M.J. Páscoa, Sandia Machado, Luís M. Magalhães*, João A. Lopes (2015) Value-adding to red grape pomace exploiting eco-friendly FT-NIR spectroscopy technique, Food Bioproc. Technol., 8, 865-874 [doi:10.1007/s11947-014-1454-z]

Santos Ferreira I, Bettencourt A, Bétrisey B, Gonçalves LMD, Trampuz A, Almeida AJ (2015). Improvement of antibacterial activity of daptomycin-loaded polymeric microparticles by Eudragit RL100: an assessment by isothermal microcalorimetry. Int J Pharm. 485: 171-182.

Santos Ferreira I, Gonçalves LMD, Kasper S, Bétrisey B, Kikhney J, Moter A, Trampuz A, Bettencourt AF, Almeida AJ (2015). Activity of daptomycin and vancomycin-loaded poly-epsilon-caprolactone microparticles against mature staphylococcal biofilms. Int J Nanomed. 10: 4351-4366.

Santos JM, Camões JP, Filipe E, Cipriano M, Bárcia RN, Filipe M, Teixeira M, Simões SI, Gaspar MM, Mosqueira D, Nascimento DS, Pinto-do-Ó P, Cruz P, Cruz H, Castro M, Miranda JP. (2015) 3D spheroid cell culture of umbilical cord tissue-derived MSCs (UCX®) leads to enhanced paracrine induction of wound healing, Stem Cell Research & Therapy. 6 (90): 1-19. DOI: 10.1186/s13287-015-0082-5

Silvana Moreira, Jorge Sarraguça, Daniel Saraiva, Renato Carvalho, Joao Almeida Lopes* (2015) Optimization of NIR spectroscopy based PLSR models for critical properties of vegetable oils used in biodiesel production, Fuel, 150, 697-704 [doi: 10.1016/j.fuel.2015.02.082]

Sousa C, Botelho J, Grosso F, Silva LJ, Lopes JA and Peixe L* (2015) Unsuitability of MALDI-TOF MS to discriminate Acinetobacter baumannii clones under our routine experimental conditions. Front. Microbiol., 6, Article 481 [doi: 10.3389/fmicb.2015.00481]

Susana A Lopes*, Jorge MG Sarraguça, João A Lopes, Maria E Duarte (2015) A new approach to talent management in law firms: integrating performance appraisal and assessment center data, Int. J. Prod. Perf. Manag., 64(4), 523-543 [doi:10.1108/IJPPM-08-2013-0147]

Vanessa Sainz, João Conniot, Ana I Matos, Carina Peres, Liane Moura, Liana C Silva, Helena F Florindo, Rogério Gaspar* (2015) “Regulatory Aspects on Nanomedicine” Biochem Biophys Res Commun, 468 (3): 504-510, doi: 10.1016/j.bbrc.2015.08.023


Capítulos de livros/Book chapters

Bettencourt A, Almeida AJ (2015). Poly(methyl methacrylate) (PMMA): drug delivery carrier applications. In: Mishra MK, (ed), Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. CRC Press, Taylor & Francis, (ISBN-13: 978-1-4398-9879-6), pp. 6511-6525.

Oliveira RF, Flores P, Teixeira SF, Marques HMC, Teixeira JC. A Form-Closed Cam-Follower Mechanism for a Breath Simulator Machine. In: Flores P, Viadero F, editors. New Trends Mech. Mach. Sci. [Internet]. Springer International Publishing; 2015 [cited 2014 Aug 30]. pp. 129–37. Available from:

Louro AH, Bettencourt A, Gonçalves LM, Almeida AJ, Silva MJ (2015). The role of nanogenotoxicology studies in safety evaluation of nanomaterials. In: Thomas S, Grohens Y, Ninan N (eds). Nanotechnology Applications in Tissue Engineering. Elsevier Inc. (ISBN: 978-0-323-32889-0), pp. 263-284.

Ricardo N.M.J. Páscoa, Mafalda C. Sarraguça, Luis M. Magalhães, João R. Santos, António O.S.S. Rangel, João A. Lopes. (2015) Chapter 103: Use of near infrared spectroscopy for coffee beans quality assessment, pag. 933-942. In: Coffee in health and disease prevention, Section 4 – Analysis and Methods. Edited by Victor R. Preedy, Academic Press, Elsevier, London, UK 2015 (ISBN: 978-0-12-409517-5)

R. Pascoa, M. Lopo, C. Santos, J.A. Lopes, (2015) Applications of Portable Near-Infrared Spectrometers in Encyclopedia of Analytical Chemistry, 1-27, Edited by R.A. Meyers, John Wiley: Chichester. UK. 2015 (ISBN: 9780470027318)

Sá Couto, A, Salústio, P, Cabral-Marques, H. Cyclodextrins. In: Ramawat, KG, Mérillon, J-M, (eds). • Adeoye, O.; Figueiredo, A and Cabral-Marques, H. Polysaccharides: Bioactivity and Biotechnology. Springer International Publishing, 2015, Pp. 247-288

Vitorino C, Almeida AJ, Sousa JJ, Pais AACC (2015). Crossing the skin barrier: a development strategy. In: Pais AACC, Sousa JJ, Vitorino C (eds), Simvastatin Delivery: Challenges and Opportunities. Nova Science Publishers, Inc., New York (ISBN: 978-1-63482-148-3), pp. 61-91.



Goncalves, M.C.H.B., Fortes, L.M.A., Martins, M.B.A.F., Carvalho, A.M.F.C.D., Feio, A.G.M. Mulfuntional superparamagnetic nanosystem as contrast agente for magnetic resonance imaging and its production method. PCT Patent, WO 2015026252A1.


A. Sá Couto, J. Vieira, H. Florindo, M. Videira, H. Cabral-Marques. Characterisation of DM-β-cyclodextrin:prednisolone complexes and their formulation as eye drops. J Incl Phenom Macrocycl Chem (2014) 80(1-2):155–164. DOI: 10.1007/s10847-014-0420-8

Ana R.P. Varela, Amélia M.P.S. Gonçalves da Silva, Alexander Fedorov, Anthony H. Futerman, Manuel Prieto, Liana C. Silva*, (2014) “Influence of intracellular membrane pH on sphingolipid organization and membrane biophysical properties” Langmuir , 30: 4094-4104 doi: 10.1021/la5003397

Ângela Novais, Clara Sousa, Juan de Caballero, Ana Fernandez-Olmos, João Lopes, Maria Helena Ramos, Teresa M Coque, Rafael Cantón, Luísa Peixe* (2014) MALDI-TOF mass spectrometry as a tool for the discrimination of high-risk Escherichia coli clones from phylogenetic groups B2 (ST131) and D (ST69, ST405, ST393), Eur. J. Clin. Microbiol. Infec. Dis., 33(8), 1391-1399 [doi: 10.1007/s10096-014-2071-5]

Antunes, A.M., Teixeira, C., Corvo, M.L., Perdigoto, R., Barroso, E. Marcelino, P. 2014. Prophilactic Use of Liposomal Amphotericin B in Preventing Fungal Infections Early After Liver Transplantation. A Retrospective, SingleCenter Study. Transplantation Proceedings 46(10), 3554–3559. DOI: 10.1016/j.transproceed.2014.06.065

Ascenso A, Ribeiro H, Marques H, Oliveira H, Santos C, Simões S. Chemoprevention of Photocarcinogenesis by Lycopene. Experimental Dermatology. 2014, 23 (12): 874–878

Ascenso A., Ribeiro H., Marques H.C., Oliveira H., Santos C., Simões S.. Is Tretinoin still a Key Agent for Photoaging Management? Mini-Review in Medicinal Chemistry, 2014, 14 (8): 629-641

Ascenso A, Salgado A, Euletério C, Praça F, Bentley MV, Marques HC, et al. In Vitro and In Vivo Topical Delivery Studies of Tretinoin – Loaded Ultradeformable Vesicles European Journal of Pharmaceutics and Biopharmaceutics. 2014, 88(1):48-55

Branquinho R, Sousa C, Lopes J, Pintado M, Peixe L, Osório H* (2014) Differentiation of Bacillus pumilus and Bacillus safensis using MALDI-TOF-MS, PLOS ONE, 9(10), 1-10 (e110127) [doi: 10.1371/journal.pone.0110127]

Bruno M. Castro, Manuel Prieto, Liana C. Silva* (2014) “Ceramide: a simple sphingolipid with unique biophysical properties”, Prog Lipid Res, 54: 53-67 doi: 10.1016/j.plipres.2014.01.004

Caetano LA, Almeida AJ, Gonçalves LMD (2014). Approaches to tuberculosis mucosal vaccine development using nanoparticles and microparticles: a review. J Biomed Nanotechnol. 10: 2295-2316.

Carrasco MP, Newton AS, Gonçalves L, Góis A, Machado M, Gut J, Nogueira F, Hänscheid Th, Guedes RC, Santos DJ, Rosenthal PhJ, Moreira R (2014). Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial. Eur. J. Med. Chem. 80:(10): 523–534.

Carvalho, A., Martins, M. B. F., Corvo, M.L., Feio G. (2014) Enhanced contrast efficiency in MRI by PEGylated magnetoliposomes loaded with PEGylated SPION: Effect of SPION coating and microenvironment. Materials Science & Engineering. C, Materials for biological applications 43: 521-526.

Couto M.C.M., Pinto I., Madureira T.V., Rocha M.J., Tiritan M.E., Lopes J.A., Almeida A.A.* (2014), Lower Douro river basin (Portugal) water quality – Focus on trace element changes and anthropogenic sources of contamination, Global NEST Journal, 16(2), 251-267

C.C.S. Sousa, F. Grosso, L. Meirinhos-Soares, L. Peixe, J.A. Lopes* (2014) Identification of carbapenem-resistant A. baumannii clones using infrared spectroscopy, J. Biophoton., 7(5), 287–294 [doi: 10.1002/jbio.201200075]

Clara Sousa, Liliana Silva, Filipa Grosso, João P. Lopes, Luísa Peixe* (2014) Development of a FTIR-ATR based model for typing clinically relevant Acinetobacter baumannii clones belonging to ST98, ST103, ST208 and ST218, J. Photochem. Photobiol. B, 133,  108-114 [doi:10.1016/j.jphotobiol.2014.02.015]

Eva Zupancic, Ana Carreira, Rodrigo F. M. de Almeida, Liana C. Silva* (2014) “Biophysical Implications of sphingosine accumulation in membrane properties at neutral and acidic pH” J. Phys. Chem. B, 118 (18): 4858-4866 doi: 10.1021/jp501167f

Eva Zupančič, J M Silva, Mafalda A Videira, João N Moreira, Helena F Florindo. Development of a novel nanoparticle-based therapeutic vaccine for breast cancer immunotherapy. Procedia in Vaccinology. 2014, 8C: 62-67 DOI: 10.1016/j.provac.2014.07.011

Joana M. Silva, Gaëlle Vandermeulen, Vanessa G. Oliveira, Sandra N. Pinto, Catarina Rodrigues, Carlos A. Afonso, Christine Jérôme, Liana C. Silva, Luis Graça, Véronique Préat, Helena F. Florindo* (2014) “Development of Functionalized Nanoparticles for Vaccine Delivery to Dendritic Cells: a Mechanistic Approach” Nanomedicines, 9 (17), 2639-2669 doi: 10.2217/mnm.14.135

João Conniot, Joana M. Silva, Joana G. Fernandes, Liana C. Silva, Rogério Gaspar, Steve Brocchini, Helena Florindo*, Teresa Barata*, (2014) “Cancer immunotherapy: role of nanodelivery approaches for combined targeting and tracking of immune cells”, Frontiers in Chemistry, Research Topic: Cancer Nanotheranostics: What have we learned so far? Front. Chem, 2:105. doi: 10.3389/fchem.2014.00105  Invited

Lopes RM, Gaspar MM, Pereira J, Eleutério CV, Carvalheiro M, Almeida AJ, Cruz MEM (2014). Liposomes versus lipid nanoparticles: comparative study of lipid-based systems as oryzalin carriers for the treatment of leishmaniasis. J Biomed Nanotechnol. 10: 3647-3657.

Mafalda C. Sarraguça, Paulo R. Ribeiro, Adenilson Santos, Marta C. Silva, João A. Lopes* (2014) A PAT approach for the on-line monitoring of pharmaceutical co-crystals formation with near infrared spectroscopy, Int. J. Pharm., 471, 478-484  [doi:10.1016/j.ijpharm.2014.06.003]

Matos AC, Gonçalves LM, Rijo P, Vaz MA, Almeida AJ, Bettencourt AF (2014). A novel modified acrylic bone cement matrix. A step forward on antibiotic delivery against multiresistant bacteria responsible for prosthetic joint infections. Mater Sci Eng C. 38: 218–226.

Martins, M.B.F., Corvo, M.L., Marcelino, P., Marinho, H.S., Feio,G., Carvalho, A. (2014) New long circulating magnetoliposomes as contrast agents for detection of ischemia-reperfusion injuries by MRI. Nanomedicine: Nanotechnology, Biology, and Medicine 10(1): 207-214.

Marto J, Baltazar D, Duarte A, Fernandes A, Gouveia L, Militão M, Salgado A, Simões S, Oliveira E, Ribeiro HM (2014) Topical gels of etofenamate: in vitro and in vivo evaluation. Pharm Dev Technol. 20:710-715.

Monteiro A, Gonçalves LM, Santos MMM (2014). Synthesis of novel spiropyrazoline oxindoles and evaluation of cytotoxicity in breast cancer cell lines. Eur. J. Med. Chem. 79: 266–272.

M.C. Gonçalves and Barbara Martins, “Multifunctional core-shell nanostructures in: Nanomedicine”, ed. by Dr N. Ali (UK) and Professor Alexander Seifalian (UK), One Central Press Office, Manchester, UK p. (2014) (ISBN 978-1-910086-00-1 Hardback; 978-1-910086-01-8 eBook-PDF).

N. Drumond, A. Sá Couto, Ana Costa, H.M. Cabral-Marques, Study of aerodynamic and release properties of inhaled particles containing cyclodextrins. J Incl Phenom Macrocycl Chem (2014) 80(1-2):25–30. DOI: 10.1007/s10847-014-0400-z

N. Arriagas, H.M. Cabral-Marques, S Obtention and characterization of a ciclesonide – methyl-beta cyclodextrin complex. J Incl Phenom Macrocycl Chem (2014) 80:125–132. DOI: 10.1007/s10847-014-0416-4

Nuno Martinho, Helena Florindo, Liana Silva, Steve Brocchini, Mire Zloh* and Teresa Barata* (2014), “Molecular Modeling for Dendrimers’ Design and Biomedical Applications”, Molecules, 19 (12), 20424-20467  doi: 10.3390/molecules191220424.

Oliveira R, Guedes R, Meireles P, Albuquerque I, Gonçalves L, Pires E, Bronze M. Gut. J, Rosenthal Ph, Prudêncio M, Moreira R, O’Neill P, Lopes F (2014). Tetraoxane-Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials. J. Med. Chem. 57(11):4916-23.

Raquel Branquinho, Clara Sousa, Hugo Osório, Luís Meirinhos-Soares, João A. Lopes, João A. Carriço, Hans-Jurgen Busse, Amir Abdulmawjood, Gunter Klein, Peter Kampfer, Manuela E. Pintado, Luísa V. Peixe* (2014) Bacillus invictae sp. nov., isolated from health products in Portugal, Int. J. Syst. Evol. Microbiol., 64, 3867-3876 [doi: 10.1099/ijs.0.067850-0]

R.G. Saraiva, J.A. Lopes, J. Machado, P. Gameiro, M.J. Feio* (2014) Discrimination of single-porin Escherichia (E.) coli mutants by ATR and transmission mode FTIR spectroscopy, J. Biophoton., 7(6), 392-400 [doi: 10.1002/jbio.201200131]

R. Matias, P.R.S. Ribeiro, M.C. Sarraguça, J.A. Lopes* (2014) A UV spectrophotometric method for the determination of folic acid in pharmaceutical tablets and dissolution tests, Anal. Met., 6(9), 3065-3071 [doi:10.1039/C3AY41874J]

Rodrigues MA, Tiago JM, Padrela L, Matos HA, Nunes TG, Pinheiro L, Almeida AJ, Gomes de Azevedo E (2014). New thermoresistant polymorph from CO2 recrystallization of minocycline hydrochloride. Pharm Res. 31: 3136-3149.

Sá Couto, D. E. Cardoso, H.M. Cabral-Marques, Validation of an HPLC analytical method for quantitative / qualitative determination of fluticasone propionate in inhalation particles on several matrixes, Scientia Pharmaceutica (2014) 82:787–797. (DOI:10.3797/scipharm.1404-11)

Sandra N. Pinto, Elad L. Laviad, Johnny Stiban, Samuel L. Kelly, Alfred H. Merrill, Manuel Prieto, Anthony H. Futerman, Liana C. Silva*, (2014) “Changes in membrane biophysical properties induced by sphingomyelinase depend on the sphingolipid N-acyl chain”, J. Lip. Res., 55: 53-61 doi: 10.1194/jlr.M042002.

Sílvia Mas, Catarina Miguel, Maria João Melo, João A. Lopes, Anna de Juan (2014) Screening and quantification of proteinaceous binders in medieval paints based on micro-Fourier transform infrared spectroscopy and multivariate curve resolution alternating least squares, Chemom. Intell. Lab Syst., 134, 148-147 [doi:10.1016/j.chemolab.2014.03.012]

Sousa C, Botelho J, Silva L, Grosso F, Nemec A, Lopes JA, Peixe L* (2014) MALDI-TOF MS and chemometric based identification of Acinetobacter calcoaceticus-Acinetobacter baumannii complex species. Int. J. Med. Microbiol., 304, 669-677 [doi:10.1016/j.ijmm.2014.04.014]

Sousa C, Silva L, Grosso F, Nemec A, Lopes J, Peixe L.* (2014) Discrimination of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex species by Fourier Transform Infrared Spectroscopy, Eur. J. Clin. Microbiol. Infec. Dis., 33(8), 1345-1353 [doi: 10.1007/s10096-014-2078-y]

Vanessa Otero, Diogo Sanches, Cristina Montagner, Márcia Vilarigues, Leslie Carlyle, João A. Lopes, Maria J. Melo* (2014) Characterisation of metal carboxylates by Raman and infrared spectroscopy in works of art, J. Raman Spectrosc., 45, 1197-1206  [doi:10.1002/jrs.4520]

Vitorino C, Almeida AJ, Sousa JJ, Lamarche I, Gobin P, Marchand S, Couet W, Olivier, JC, Pais AACC (2014). Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: in vitro vs in vivo studies. Eur J Pharm Biopharm. 86: 133–144.


Capítulos de livros/Book chapters

Almeida AJ, Grenha A (2014). Technosphere®: an inhalation system for pulmonary delivery of biopharmaceuticals. In: Neves J, Sarmento B (eds), Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies. Springer, New York (ISBN: 978-1-4614-9523-9), pp. 483-498.

Clara C. Sousa and João A. Lopes. (2014) Chapter 20: Infrared spectroscopy detection coupled to chemometrics to characterize foodborne pathogens at a subspecies level, page 385. In: Mathematical and statistical approaches in food science and technology. Edited by Daniel Granato and Gáston Ares, IFT Press – Wiley-Blackwell, UK 2014 (ISBN: 978-1-118-43368-3)

Gaspar, R.S., Florindo; H.S., Silva, L.C., Videira, M.A; Corvo, M.L., Martins, M.B.F., SilvaLima, B. (2014) Regulatory Aspects of Oncologicals: Nanosystems Main Challenges “in” NanoOncologicals: New Targeting and Delivery Approaches, Advances in Delivery Science and Technology, M.J. Alonso, M. GarciaFuentes (eds.), Publisher: Springer International Publishing Switzerland. pp 425452. 2014. ISBN 978-3-319-08083-3

Helena F Florindo, João A Lopes, Liana C Silva, L Corvo, MB Martins, R Gaspar. Regulatory development of Nanotechnology-based vaccines. in Micro and Nanotechnology in Vaccine Development, edited by Dr Mariusz Skwarczynski and Professor Istvan Toth, Elsevier ISBN: 978-0-323-39981-4;

Laure Lambricht, Carina Peres, Helena F Florindo, Véronique Préat, Gaëlle Vandermeulen. Polymer-based nanoparticles as modern vaccine delivery systems. in Micro and Nanotechnology in Vaccine Development, edited by Dr Mariusz Skwarczynski and Professor Istvan Toth, Elsevier

Oliveira RF, Ferreira ACM, Teixeira SFCF, Teixeira JC, Marques HMC. A CFD Study of a pMDI Plume Spray. In: Yang G-C, Ao S-I, Gelman L, editors. Trans. Eng. Technol. [Internet]. Springer Netherlands; 2014. p. 163–76. Available from:

Praça, F.S., Marinho, H.S., Martins, M.B.F., Gaspar, R.S., Corvo, M.L., Medina, W. Current aspects of breast cancer therapy and diagnosis based on a nanocarrier approach, in Nanostructures for Cancer Therapy Alexandru Mihai Grumezescu and Anton Ficai, ed. Chapter 27. Elsevier. 2017 (in press)

Praça, F.S., Marinho, H.S., Martins, M.B.F., Gaspar, R.S., Corvo, M.L., Medina, W.  Current aspects of breast cancer therapy and diagnosis based on a nanocarrier approach, in Nanostructures for Cancer Therapy Alexandru Mihai Grumezescu and Anton Ficai, ed. Chapter 27. Elsevier. 2017 (in press)

Rodrigo F.M. de Almeida, Joaquim T. Marquês and Liana C. Silva* (2014) “Biophysics of lipid rafts and their interplay with ceramide. Studies in models systems and biological insights.” In: Daniel Sillence (Eds) “Lipid Rafts: Properties, Role in Signal transduction”, Chapter 2, Nova Science Publishers Inc, New York, ISBN: 978-1-62948-964-3, Invited; CA



Brachkova MI, Duarte MA, Pinto JF. (2012) Alginate films containing viable Lacotbacillus plantarum: preparation and in vitro evaluation. AAPS PharmSci Tech DOI 10.1208/s12249-012-9753-z.

Carvalho A, Gonçalves MC, Martins MBF, Meixedo D, Feio G (2013). Relaxivities of magnetoliposomes: the effect of cholesterol. Magnetic Resonance Imaging. in press:;

Carvalho A, Gonçalves MC, Martins MBF, Meixedo D, Feio G. Relaxivities of Magnetoliposomes: the Effect of Cholesterol.  Magnetic Resonance Imaging  31 (2013)  610-612. DOI: 10.1016/j.mri.2012.10.024

Colaço R, Gonçalves MC, Fortes LM, Gonçalves LMD, Almeida AJ,  and Martins BF. Preparation and Chemical Characterization of Eco-friendly ORMOSIL Nanoparticles of Potential Application in DNA Gene Therapy.  Current Nanoscience  9 (2013) 168-172. DOI: 10.2174/157341313805117875

Colaço R, Gonçalves MC, Fortes LM, Goncalves LMD, Almeida AJ, Martins MBF (2013). Preparation and Chemical Characterization of Eco-friendly ORMOSIL Nanoparticles of Potential Application in DNA Gene Therapy. Current Nanoscience. 9:168-172.;

Faria MR, Cruz MM, Gonçalves MC, Carvalho A, Feio G, Martins MBF (2013). Synthesis and characterization of magnetoliposomes for MRI contrast enhancement. Int.J.Pharm. 446:183-190.;

Faria MR, Margarida Cruz M, Gonçalves MC, Carvalho A, Feio G, Martins MBF.  Synthesis and Characterization of Magnetoliposomes for MRI Contrast Enhancement.  International   Journal of  Pharmaceutics  446 (2013) 183-190.     DOI: 10.1016/j.ijpharm.2013.02.025

Gaspar R (2013). NANOPARTICLES Pushed off target with proteins. Nature Nanotechnology. 8:79-80. Accession Number: WOS:000315178800011;

Martins MBF, Corvo ML, Marcelino P, Marinho HS, Feio G, Carvalho A. New long circulating magnetoliposomes as contrast agents for detection of ischemia-reperfusion injuries by MRI. Nanomedicine: Nanotechnology, Biology and Medicine, in press.DOI: 10.1016/j.nano.2013.06.008

Mello-Sampayo C, Corvo ML, Mendes R, Duarte D, Lucas JR, Batista AP, Raymundo A, Silva-Lima B, Bandarra MN, Gouveia L. (2013). Insights on the safety of carotenogenic Chlorella vulgaris in rodents, Algal Research in press.

Müllers KC, Wahl MA, Pinto JF. (2013) Multilayer laminar co-extrudate as a novel controlled release dosage form, Eur. J. Pharm. Sci. 49:491-498.

Müllers KC, Wahl MA, Pinto JF. (2013) Production of dosage forms for oral drug delivery by laminar extrusion of wet masses, Eur. J. Pharm. Sci. 84:626-632.

Oliveira G, Wahl MA, Pinto JF. (2013) Characterization of laminar extrudates manufactured at room temperature in the absence of solvents for the delivery of drugs, Int. J. Pharm. 454:90-98.

Pina MF, Pinto JF, Sousa JJ, Fábián L, Zhao M, Craig DQM. (2012) Identification and Characterization of Stoichiometric and Nonstoichiometric Hydrate Forms of Paroxetine HCl: Reversible Changes in Crystal Dimensions as a Function of Water Absorption, Mol. Pharm. 9:3515-3525.

Pinto SN, Fernandes F, Fedorov A, Futerman AH, Silva LC*, Prieto M (2013) “A combined fluorescence spectroscopy, confocal and 2-photon microscopy to re-evaluate the properties of sphingolipid domains”, Biochim. Biophys. Acta (Biomembranes), 1828 (9): 2099-2110 doi: 10.1016/j.bbamem.2013.05.011

Reis CP, Martinho N, Rosado C, Fernandes AS, and Roberto A. “Design of polymeric nanoparticles and its applications as drug delivery systems for acne treatment. (2013) Drug Development and Industrial Pharmacy. DOI: 10.3109/03639045.2013.767826

Silva JM, Videira M, Gaspar R, Préat V, Florindo HF (2013). Immune System Targeting by Biodegradable Nanoparticles for Cancer Vaccines. Journal of Controlled Release.;

Varela ARP, Gonçalves da Silva AMPS, Fedorov A, Futerman AH, Prieto M, Silva LC (2013). Effect of glucosylceramide on the biophysical properties of fluid membranes. Biochimica et Biophysica Acta-Biomembranes. 1828:1122-1130.;

Varela ARP, Gonçalves da Silva AMPS, Fedorov F, Futerman AH, Prieto M, Silva LC(2013) “Effect of glucosylceramide on the biophysical properties of fluid membranes”, Biochim. Biophys. Acta – Biomembranes, 1828 (3): 1122-1130 doi: 10.1016/j.bbamem.2012.11.018

Vicente J, Pinto JF, Menezes JC, Gaspar F. (2013) Applying Quality by Design to spray drying – The role of empirical and mechanistic modeling, Chemistry Today 31:32-35.

Vicente J, Pinto JF, Menezes JC, Gaspar F. (2013) Fundamental analysis of particle formation in spray drying Powder Technology, Powder Technology (accepted for publication).

Videira M, Arranja AG, Gouveia LF (2013). Experimental design towards an optimal lipid nanosystem: a new opportunity for Paclitaxel-based therapeutics. European Journal of Pharmaceutical Sciences.;

Viola J, Rafael DF, Wagner E, Besch R and Ogris M (2013) Gene therapy for advanced melanoma: selective targeting and therapeutic nucleic acids. Journal of Drug Delivery, vol.2013, Article ID 897348, 15 pages, 2013. Doi:10.1155/2013/897348.
Salústio PJ, Pinto JF, Costa PC, Cabral-Marques HM. (2013) Release profiles of indometacin in β-cyclodextrin complexes from HPMC capsules. J. Incl. Phenom. Macrocycl. Chem., 75:101-109.


Capítulos de livros/Book chapters

Joana Silva, Eva Zupancic, Carina Peres, Rogério Gaspar, Véronique Préat and Helena F Florindo. Immunomodulation against microbial pathogens through dendritic cells. (2013) In: A. Méndez-Vilas (ed.) Microbial pathogens and strategies for combating them: science, technology and education. Formatex Research Center. In press

Joana Silva, Véronique Préat and Helena F Florindo. (2013) Aliphatic Polyesters: Particulate Vaccine Delivery. Chapter for “Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, Taylor and Francis Group. In press

Rafael DF, Andrade F., Arranja A, Luís AS, Videira M. (2013) Lipoplexes and Polyplexes: Gene Delivery Applications. In: The Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, Taylor&Francis Group LLC, In press.

Rafael DF, Videira M, Oliva M, Ferreira D, Sarmento B, Andrade F. (2013) Amphiphilic polymers in drug delivery. In: The Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, Taylor&Francis Group LLC, In press.



Rodrigues MAJ, Padrela LMB, Azevedo EJSG, Matos HAS, Almeida AJLN, Gonçalves LMD (2013). Vaccine Against Strangles of the Equidae, 06.09.2013, WO2013/129953, PCT/PT2013/000012.

Gois PMP, Montalbano F, Cal PMDS, Carvalho MABR, Gonçalves LMD, (2013). Boron heterocycles as new inhibitors of human neutrophil elastase. June 2013, WO 2013/084199 A1. PCT/IB2012/057064.

Design Number – 002319590, Office for Harmonization in the internal Market, Trade Marks and Designs. Design of a nose-only-chamber, for several animals simultaneously, promoting the targeted pulmonary administration of dry powder formulations, Marques H.C., Gaspar M.M., Simões S.I., 2013



Figueiredo L, Cadete A, Goncalves LMD, Corvo ML, Almeida AJ (2012). Intranasal immunisation of mice against Streptococcus equi using positively charged nanoparticulate carrier systems. Vaccine. 30:6551-6558.;

Gaspar R, Aksu B, Cuine A, Danhof M, Takac MJM, Linden HH, Link A, Muchitsch EM, Wilson CG, Ohrngren P, Dencker L (2012). Towards a European Strategy for Medicines Research (2014-2020): The EUFEPS Position Paper on Horizon 2020. European Journal of Pharmaceutical Sciences. 47:979-987.;

Lopes RM, Corvo ML, Eleuterio CV, Carvalheiro MC, Scoulica E, Cruz ME (2012). Formulation of oryzalin (ORZ) liposomes: In vitro studies and in vivo fate. Eur.J.Pharm.Biopharm. 82:281-290.;

Moura V, Lacerda M, Figueiredo P, Corvo ML, Cruz MEM, Soares R, de Lima MCP, Simoes S, Moreira JN (2012). Targeted and intracellular triggered delivery of therapeutics to cancer cells and the tumor microenvironment: impact on the treatment of breast cancer. Breast Cancer Research And Treatment. 133:61-73.;

Rodrigues MA, Figueiredo L, Padrela L, Cadete A, Tiago J, Matos HA, de Azevedo EG, Florindo HF, Goncalves LMD, Almeida AJ (2012). Development of a novel mucosal vaccine against strangles by supercritical enhanced atomization spray-drying of Streptococcus equi extracts and evaluation in a mouse model. European Journal of Pharmaceutics and Biopharmaceutics. 82: 392-400.;

Silva LC, Ben David O, Pewzner-Jung Y, Laviad EL, Stiban J, Bandyopadhyay S, Merrill AH, Prieto M, Futerman AH (2012). Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes. Journal of Lipid Research. 53:430-436.;

Singh A, Wang HT, Silva LC, Na CZ, Prieto M, Futerman AH, Luberto C, Del Poeta M (2012). Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans. Cellular Microbiology. 14:500-516.;

Videira M, Almeida AJ, Fabra A (2012). Preclinical evaluation of a pulmonary delivered paclitaxel-loaded lipid nanocarrier antitumor effect. Nanomedicine-Nanotechnology Biology and Medicine. 8:1208-1215.;

Videira MA, Santos AC, Botelho MF. (2012) Biodistribution of Lipid Nanoparticles: a comparative study of pulmonary versus intravenous Administration in rats. Current Radiopharmaceuticals. 5(2):158-165.  DOI: 10.2174/1874471011205020158;


Capítulos de livros/Book chapters

Almeida AJ, Florindo, HF. Nanostructures overcoming the nasal barrier: Physiological considerations and mechanistic issues. (2012) In: Alonso MJ, Csaba NS (eds), Nanostructured Biomaterials for Overcoming Biological Barriers. RSC Publishing, Cambridge, 2012;117-132. DOI:10.1039/9781849735292-00117

Andrade F, Videira F, Ferreira D, Sosnik A, Sarmento B. (2012) nanotechnology and pulmonary delivery of anti-infectious drugs. In: Ali Eftekahari (ed), Emoerging Topics in Nanotechnology, John Wiley&Sons, In press.

Videira M and Gaspar R. (2012) Patentability and Intellectual Property Issues Related to Chitosan-based biopharmaceutical products. In: Sarmento B, Neves J (Eds) Chitosan-based systems for biopharmaceuticals: Delivery, targeting and polymer Therapeutics. John Wiley & Sons, Ltd. (DOI:10.1002/9781119962977.ch25).