Investigação > Publicações


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  • 2016

Assoah, B., Veiros, L. F. Afonso, C. A. M. Candeias, N. R. (2016) Biomass-Based and Oxidant-Free Preparation of Hydroquinone from Quinic Acid. Eur. J. Org. Chem., In Press, DOI: 10.1002/ejoc.201600616

Bonito, C. A., Leandro, P., Ventura F. V. & Guedes, R. C. (2016). Chemical Biology & Drug Design, 2(88), 281–292, doi:10.1111/cbdd.12755

Calado, S., Eleutério, C., Mendes, E., Rocha, M.J., Francisco, A.P., & Gaspar, M.M. (2016), Nanoformulations of a Triazene Analogue with Specific Affinity to Human Melanoma. Journal of Nanoscience with Advanced Technology, 1(4): 1-9

Carrasco, M. P., Machado, M., Gonçalves, L., Sharma, M.,  Gut, V., Lukens, A. K., Wirth, D. F.,  André, V.,  Duarte, M. T. , dos Santos, D. J. V. A. , Guedes, R. C.,  Rosenthal, P. J., Mazitschek, R., Prudêncio, M., R. Moreira, R., Probing the azaaurone scaffold against the hepatic and erythrocytic stages of malaria parasites, ChemMedChem, 2016, in press. DOI: 10.1002/cmdc.201600327.

Carvalho, A. N., Marques, C., Guedes, R. C, Castro-Caldas, M., Rodrigues, E., Van Horssen, J., & Gama, M. J. (2016). S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection FEBS Lett., 590(10), 1455-1466, doi:10.1002/1873-3468.12177

Daniel, C. I., Rubio, A. M., Sebastiao, P. J., Afonso, C. A. M., Storch, J., Izak, P., Portugal, C. A. M., and Crespo, J. G. (2016) Magnetic modulation of the transport of organophilic solutes through Supported Magnetic Ionic Liquid Membranes, Journal of Membrane Science 505, 36-43.

Faustino, C., Serafim, C., Rijo, P., Reis, C. P. (2016). Bile acids and bile acid derivatives: use in drug delivery systems and as therapeutic agents. Expert Opinion on Drug Delivery. Doi:10.1080/17425247.2016.1178233.

Guedes, R.A., Serra, P., Salvador, J. A. R., & Guedes, R. C. (2016). Computational Approaches for the Discovery of Human Proteasome Inhibitors: An Overview. Molecules, 21, 927. doi:10.3390/molecules21070927

Guerreiro, P. S., Estácio,S. G., Antunes, F., Fernandes, A. S., Pinheiro, P. F., Costa, J. G., Castro, M., Miranda, J. P., Guedes, R. C., & Oliveira, N. G. (2016). Structure-based virtual screening towards the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1 Chemical Biology & Drug Design; Accepted manuscript online: 23 JUL 2016, doi:10.1111/cbdd.12826

Ladeiras, D., Monteiro, C. M., Pereira, F., Reis, C. P., Afonso, C. A. M., and Rijo, P. (2016) Reactivity of Diterpenoid Quinones: Royleanones, Current Pharmaceutical Design 22, 1682-1714.

Martins, C. F., Neves, L. A., Estevão, M., Rosatella, A., Alves, V.D., Afonso, C.A.M. Crespo, J.G. Coelhoso, I.M.(2016) Effect of water activity on carbon dioxide transport in cholinium-based ionic liquids with carbonic anhydrase. Separation and Purification Technology, 168, 74-82; doi:10.1016/j.seppur.2016.05.004

Matos A.C., Marques C.F., Pinto R.V., Ribeiro I.A.C., Goncalves L.M., Vaz M.A., Ferreira J.M.F., Almeida A.J., Bettencourt A.F. (2015) Novel doped calcium phosphate-PMMA bone cement composites as levofloxacin delivery systems. International Journal of Pharmaceutics. 490, 200-208.

Restolho, J. Barroso, M., Saramago, B., Dias, M., Afonso, C. A. M. (2016). Contactless decontamination of hair samples: cannabinoids; Drug Testing and Analysis, 2016, DOI: 10.1002/dta.1958

Ribeiro, C. J. A., Amaral, J. D., Rodrigues, C. M. P., Moreira, R., Santos, M. M. M. (2016). Spirooxadiazoline oxindoles with promising in vitro antitumor activities. Med. Chem. Commun. (“New Talent: Europe” issue), 7, 420-425. doi: 10.1039/C5MD00450K

Ribeiro, C. J. A., Espadinha, M., Machado, M., Gut, J., Gonçalves, L., Rosenthal, P. J., Prudêncio, M., Moreira, R., Santos, M. M. M. (2016). Novel squaramides with in vitro liver stage antiplasmodial activity, Bioorg. Med. Chem., 24(8), 1786-1792. doi: 10.1016/j.bmc.2016.03.005

Ribeiro, C. J. A., Rodrigues, C. M. P., Moreira, R., Santos, M. M. M. (2016). Chemical Variations on the p53 Reactivation Theme, Pharmaceuticals, 9(2), 25. doi: 10.3390/ph9020025

Rosatella, A. A., Siopa, F., Frade, R. F. M., and Afonso, C. A. M. (2016) New low viscous cholinium-based magnetic ionic liquids, New Journal of Chemistry 40, 3124-3129.

Ruivo, E. F. P., Gonçalves, L. M., Carvalho, L. A. R., Guedes, R. C., Hofbauer, S., Brito, J. A., Archer, M., Moreira, R., & Lucas, S. D. (2016). Clickable 4-Oxo-b-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes ChemMedChem Accepted manuscript. doi:10.1002/cmdc.201600258

Santos, M. M. M. (2016). A QUÍMICA ORGÂNICA: Uma ferramenta essencial no desenvolvimento de novos fármacos, YoungChem, 2, 13-18.

Serafim, C., Ferreira, I., Rijo, P., Pinheiro, L., Faustino, C., Calado, A., Garcia-Rio, L. (2016). Lipoamino acid-based micelles as promising delivery vehicles for monomeric amphotericin B. International Journal of Pharmaceutics, 497, 23–35.

Simeonov, S. P., and Afonso, C. A. M. (2016) Basicity and stability of urea deep eutectic mixtures, Rsc Advances 6, 5485-5490.

Simeonov, S. P., Coelho, J. A. S., Afonso, C. A. M. (2016). Synthesis of 5‐(Hydroxymethyl)furfural (HMF). Org. Synth. 93, 29-36, DOI: 10.15227/orgsyn.093.002

Simeonov, S. P., Nunes, J. P. M., Guerra, K., Kurteva, V. B., and Afonso, C. A. M. (2016) Synthesis of Chiral Cyclopentenones, Chemical Reviews 116, 5744-5893.

Soares, J., Raimundo, L., Pereira, N. A. L., Monteiro, A., Gomes, S., Bessa, C., Pereira, C., Queiroz, G., Bisio, A., Fernandes, J., Gomes, C., Reis, F., Gonçalves, J., Inga, A., Santos, M. M. M., Saraiva, L. (2016). Reactivation of wild-type and mutant p53 by tryptophanol-derived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule, Oncotarget, 7(4), 4326-4343. doi: 10.18632/oncotarget.6775

Vale, J. R., Siopa, F., Branco, P. S., and Afonso, C. A. M. (2016) Ring Opening of 6-Azabicyclo 3.1.0 hex-3-en-2-ols in Water under Mild Conditions, European Journal of Organic Chemistry, 2048-2053

Ventura, S. P. M. Morais, P., Coelho, J. A. S., Sintra, T. Coutinho, J. A. P., Afonso C. A. M.(2016) Evaluating the toxicity of biomass derived platform chemicals. Green Chem., 2016, Advance Article, DOI: 10.1039/C6GC01211F

Book chapters

Constantino, L., Dias, C., and Valente, E. (2016) Reduction of a Ketone Using Sodium Borohydride. Control of a Reaction by TLC. In Afonso, C.A.M., et. al. (Ed.) Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. (Chapter 196, pp. 886-891) The Royal Society of Chemistry. Published by: The Royal Society of Chemistry.

Dias, C., Valente, E., and Constantino, L. (2016) Synthesis of Paracetamolby Acetylation. In Afonso, C.A.M., et. al. (Ed.) Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. (Chapter 32, pp. 146-150) The Royal Society of Chemistry. Published by: The Royal Society of Chemistry.

Dourado, J., Pérez, M., Griera, R., Santos, M. M. M. (2016). Asymmetric Cyclocondensation Reaction Induced by Chiral Auxiliary. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, ed. C. A. M. Afonso, N. R. Candeias, D. P. Simão, A. F. Trindade, J. A. S. Coelho, B. Tan, R. Franzén, Royal Society of Chemistry, UK.

Francisco, A. P., Ressurreição, A. S., Perry, M. J., & Lopes, F. Knorr Pyrazole  Synthesis of Edaravone. In:  Afonso,  C. A. M., Candeias, N. R., Simão, D. P., Trindade, A. F., Jaime A. S. Coelho, J. A. S., Tan, B.,  &  Franzén, R. (Eds). Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. 2016, Ch. 94; 416-419. The Royal Society of Chemistry. ISBN: 978-1-84973-963-4.

Lavrado, J., Figueiras, M., Pereira, D.M., Santos, S.A., Moreira, R., Paulo, A. (2016). Synthesis of Indolo[3,2-b]quinolin-11-one by Acid-Catalysed Intramolecular Double Cyclization. In: Afonso, C.A.M., Candeias, N.R., Simão, D.P. et al. (eds). Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. The Royal Society of Chemistry, Cap. 133, 585-589. ISBN: 978-1-84973-963-4.

Lavrado, J., Figueiras, M., Ruivo, E., Lucas, S., Paulo, A (2016). Benzotriazole, a Useful Synthetic Auxiliary in Heterocyclizations. In: Afonso, C.A.M., Candeias, N.R., Simão, D.P. et al. (eds). Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. The Royal Society of Chemistry, Cap. 138, 609-612. ISBN: 978-1-84973-963-4.

Lopes, F., Perry, M. J., & Francisco, A. P. Preparation of Nitrostilbenes by the Wittig reaction. In:  Afonso,  C. A. M., Candeias, N. R., Simão, D. P., Trindade, A. F., Jaime A. S. Coelho, J. A. S., Tan, B.,  &  Franzén, R. (Eds). Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. 2016, Ch. 159; 709 -713. The Royal Society of Chemistry. ISBN: 978-1-84973-963-4.

Madureira, A.M., Santana, A.B., Valente, E., and Ferreira, M.-J.U. (2016) Synthesis of Dibenzalacetone 2,4-Dinitrophenylhydrazone. In Afonso, C.A.M., et. al. (Ed.) Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. (Chapter 70, pp. 309-313) The Royal Society of Chemistry. Published by: The Royal Society of Chemistry.

Ribeiro, C. J. A., Moreira, R., Santos, M. M. M. (2016). Synthesis of a spiroisoxazoline oxindole by 1,3-dipolar Cycloaddition. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, ed. C. A. M. Afonso, N. R. Candeias, D. P. Simão, A. F. Trindade, J. A. S. Coelho, B. Tan, R. Franzén, Royal Society of Chemistry, UK.

Valente, E., Dias, C., and Constantino, L. (2016) A SN1 Reaction: Synthesis of tert-Butyl Chloride. In Afonso, C.A.M., et. al. (Ed.) Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. (Chapter 14, pp. 64-68) The Royal Society of Chemistry. Published by: The Royal Society of Chemistry.

Valente, E., Dias, C., and Constantino, L. (2016) Acetylation of Cholesterol and Purification by Column Chromatography. In Afonso, C.A.M., et. al. (Ed.) Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. (Chapter 36, pp. 162-167) The Royal Society of Chemistry. Published by: The Royal Society of Chemistry.

 

Areias, L. R. P., Ruivo, E. F. P., Goncalves, L. M., Duarte, M. T., Andre, V., Moreira, R., Lucas, S. D., & Guedes, R. C., (2015). A unified approach toward the rational design of selective low nanomolar human neutrophil elastase inhibitors RSC Adv., 64 (5), 51717-51721. doi: 10.1039/C5RA07783D

Branco, M. A., Pinheiro, L., Faustino, C. (2015). Amino acid-based cationic gemini surfactant-protein interactions. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 480, 105–112.

Brito, H., Martins, A.C., Lavrado, J., Mendes, E., Francisco, A.P., Santos, S.A., Ohnmacht, S.A., Kim, N.S., Rodrigues, C.M.P., Moreira, R., Neidle, S., Borralho, P.M., Paulo, A. (2015) Targeting KRAS oncogene in colon cancer cells with 7-carboxylate indolo[3,2-b]quinoline tri-alkylamine derivatives. PlosOne 10(5): e0126891. doi: 10.1371/journal.pone.0126891.

Brito, H., Martins, A.C., Lavrado, J., Mendes, E., Francisco, A.P., Santos, S.A., Ohnmacht, S.A., Kim, N.S., Rodrigues, C.M., Moreira, R., Neidle. S., Borralho, P.M., & Paulo, A. (2015). Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives. PLoS One. 29; 10(5):e0126891. doi: 10.1371/journal.pone.0126891.

Carvalho, L.A.R., Ruivo, E.F.P., Lucas, S.D., Moreira, R. (2015) Activity Based Probes as Molecular Tools for Biomarker Discovery. MedChemComm. 6, 536-546.

Faustino, C., Bettencourt, A. F., Alfaia, A., Pinheiro, L. (2015). Introducing students to rheological classification of foods, cosmetics, and pharmaceutical excipients using common viscous materials. Journal of Chemical Education, 92, 936–939.

Faustino, C., Serafim, C., Ferreira, I., Pinheiro, L., Calado, A. (2015). Solubilization power of an amino acid-based gemini surfactant towards the hydrophobic drug amphotericin B. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 480, 426–432.

Figueiras, .M, Coelho, L., Wicht, K.J., Santos, S.A., Lavrado, J., Gut, J., Rosenthal, P.J., Nogueira, F., Egan, T.J., Moreira, R., Paulo A. (2015) N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: Design, synthesis and antiplasmodial activity. Bioorg. Med. Chem., 23, 1530–1539. Doi: 10.1016/j.bmc.2015.02.007

Gomes, L. F. R., Veiros, L. F., Maulide, N., and Afonso, C. A. M. (2015) Diazo- and Transition-Metal-Free C-H Insertion: A Direct Synthesis of beta-Lactams, Chemistry-a European Journal 21, 1449-1453.

Gomes, R. F. A., Coelho, J. A. S., Frade, R. F. M., Trindade, A. F., and Afonso, C. A. M. (2015) Synthesis of Symmetric Bis(N-alkylaniline)triarylmethanes via Friedel-Crafts-Catalyzed Reaction between Secondary Anilines and Aldehydes, Journal of Organic Chemistry 80, 10404-10411.

Hartmann, D. O., Shimizu, K., Siopa, F., Leitao, M. C., Afonso, C. A. M., Lopes, J. N. C., and Pereira, C. S. (2015) Plasma membrane permeabilisation by ionic liquids: a matter of charge, Green Chemistry 17, 4587-4598.

Hofbauer, S., Brito, J. A., Mulchande, J., Nogly P., Pessanha, M., Moreira, R., Archer M. (2015). Stabilization of porcine pancreatic elastase (PPE) crystals by glutaraldehyde cross-linking. Acta Cryst. Section F. 71, 1346-1351.

Lavrado, J., Brito, H., Borralho, P.M., Ohnmacht, S.A., Kim, N.S., Leitão, C., Pisco, S., Gunaratnam, M., Rodrigues, C.M.P., Moreira, R., Neidle, S., Paulo, A. (2015) KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines. Sci. Rep., 5, 9696. doi:10.1038/srep09696.

Lavrado, J., Ohnmacht, S.A., Correia, I., Leitão, C., Pisco, S., Gunaratnam, M., Moreira, R., Neidle, S., dos Santos, D.J.V.A., Paulo A. (2015) Novel indolo[3,2-c]quinolines G-quadruplex stabilisers: A structural binding analysis to the human telomeric G-quadruplex. ChemMedChem, 10, 836-849. doi: 10.1002/cmdc.201500067.

Lucas, S. D., Carrasco, M. P., Goncalves, L. M., Moreira, R., & Guedes, R. C. (2015). Discovery of C-shaped aurone human neutrophil elastase inhibitors, MEDCHEMCOMM, 6, 1508-1512; doi: 10.1039/c5md00164a

Mariz, I. F. A., Siopa, F., Rodrigues, C. A. B., Afonso, C. A. M., Chen, X., Martinho, J. M. G., and Macoas, E. M. S. (2015) A 1,3,5-triazine based polymer as a nonlinear near-infrared antenna for two-photon activated volumetric optical memory devices, Journal of Materials Chemistry C 3, 10775-10782.

Matos, A. C., Ribeiro, I. A. C.; Guedes, R. C., Pinto, R., Vaz, M. A., Goncalves, L. M., Almeida, A. J., Bettencourt, A. F.  2015 “Key-properties outlook of a levofloxacin-loaded acrylic bone cement with improved antibiotic delivery” International Journal of Pharmaceutics, 485, 317-328; doi: 10.1016/j.ijpharm.2015.03.035

Monteiro, C. M., Lourenco, N. M. T., Ferreira, F. C., and Afonso, C. A. M. (2015) PEG(600)-Carboxylates as Efficient Reusable Reaction Media and Acylating Agents for the Resolution of sec-Alcohols, Chempluschem 80, 42-46.

Oliveira R., Miranda D., Magalhães J., Capela R., Perry M. J., O’Neill P. M., Moreira R., Lopes F. (2015). From hybrids compounds to targeted drug delivery in antimalarial therapy. Bioorg. Med. Chem., 23, 5120-5130. doi: 10.1016/j.bmc.2015.04.017.

Pereira, N. A. L., Monteiro, A., Machado, M., Gut, J., Molins, E., Perry, M. J., Dourado, J., Moreira, R., Rosenthal, P. J., Prudêncio, M., Santos, M. M. M. (2015). Enantiopure Indolizinoindolones with In Vitro Efficiency against Blood- and Liver-Stage Malaria Parasites, ChemMedChem, 10, 12, 2080-2089. doi: 10.1002/cmdc.201500429

Pérez, M., Espadinha, M., Santos, M. M. M. (2015). Indolo[2,3-a]quinolizidines and derivatives: Bioactivity and asymmetric Synthesis, Curr. Pharm. Design (thematic issue “Challenging organic syntheses and pharmacological applications of natural products and their derivatives”), 21, 5518-5546. doi: 10.2174/1381612821666151002112934

Restolho, J., Barroso, M., Dias, M., Afonso, C. A. M., and Saramago, B. (2015) Capture of Opiates by Ionic Liquids, Journal of Solution Chemistry 44, 440-453.

Restolho, J., Barroso, M., Saramago, B., Dias, M., and Afonso, C. A. M. (2015) Development, optimization, and validation of a novel extraction procedure for the removal of opiates from human hair’s surface, Drug Testing and Analysis 7, 385-392.

Ribeiro, I. A. C., Faustino, C. M. C., Guerreiro, P. S., Frade, R. F. M., Rosário Bronze, M., Castro, M. F., Ribeiro, M. H. L. (2015). Development of novel sophorolipids with improved cytotoxic activity toward MDA-MB-231 breast cancer cells. Journal of Molecular Recognition, 28, 155–165.

Ribeiro, I. A. C.; Faustino, C. M. C.; Guedes, R. C., Alfaia, A., Ribeiro, M. H., (2015)”, Journal of Chemical Education, 92, 924-927; doi: 10.1021/ed500384z

Rodrigues, C. A. B., Frade, R. F. M., Albuquerque, I. S., Perry, M. J., Gut, J., Machado, M., Rosenthal, P. J., Prudencio, M., Afonso, C. A. M., and Moreira, R. (2015) Targeting the Erythrocytic and Liver Stages of Malaria Parasites with s-Triazine-Based Hybrids, Chemmedchem 10, 883-890.

Rodrigues, C. A. B., Martinho, J. M. G., and Afonso, C. A. M. (2015) Synthesis of a Biologically Active Oxazol-5-(4H)-one via an Erlenmeyer-Plochl Reaction, Journal of Chemical Education 92, 1543-1546.

Santos, S.A., Lukens, A.K., Coelho, L., Nogueira, F., Wirth, D.F., Mazitschek, R., Moreira, R., Paulo, A. (2015) Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype. Eur. J. Med. Chem, 102, 320-333. doi: 10.1016/j.ejmech.2015.07.047

Soares, J., Pereira, N. A. L., Monteiro, A., Leão, M., Bessa, C., dos Santos, D. J. V. A., Raimundo, L., Queiroz, G., Bisio, A., Inga, A., Pereira, C., Santos, M. M. M., Saraiva, L. (2015). Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction, Eur. J. Pharm. Sci., 66, 138-147. doi: 10.1016/j.ejps.2014.10.006

Soares, J., Raimundo, L., Pereira, N. A. L., dos Santos, D. J. V. A., Pérez, M., Queiroz, G., Leão, M., Santos, M. M. M., Saraiva, L. (2015). A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins, Pharmacol. Res., 95-96, 42-52. doi: 10.1016/j.phrs.2015.03.006

Sousa, T., Castro, R. E., Pinto, S. N., Coutinho, A., Lucas, S. D., Moreira, R., C. Rodrigues, M.P., Prieto,M., Fernandes, F. (2015). Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties, J. Lip. Res., 56, 2158-71.

Sowmiah, S., Veiros, L. F., Esperanca, J., Rebelo, L. P. N., and Afonso, C. A. M. (2015) Organocatalyzed One-Step Synthesis of Functionalized N-AlkylPyridinium Salts from Biomass Derived 5-Hydroxymethylfurfural, Organic Letters 17, 5244-5247.

Book chapters

Faustino, C., Pinheiro, L. (2015). Antimicrobial properties and therapeutic benefits of honey in the quest for more efficient antimicrobial agents. In: The Battle Against Microbial Pathogens: Basic Science, Technological Advances and Educational Programs. A. Mendez-Vilas (Ed.), Formatex: Badajoz, pp.98–108.

Lopes, F., Santos, M. M. M., Moreira, R. (2015).Designing covalent inhibitors: A medicinal Chemistry challenge. In: Biomedical Chemistry: Current Trends and Developments, ed. N. Vale, De Gruyter Open Ltd, Warsaw/Berlin, section 1.2, 44-60.

Neto, Í., Faustino, C., Rijo, P. (2015). Antimicrobial abietane diterpenoids against resistant bacteria and biofilms. In: The Battle Against Microbial Pathogens: Basic Science, Technological Advances and Educational Programs. A. Mendez-Vilas (Ed.), Formatex: Badajoz, pp.15–26.

Pires, D., Valente, E., Simões, M.F., Carmo, N., Testa, B., Constantino, L., and Anes, E. (2015) Esters of Pyrazinoic Acid Are Active against Pyrazinamide-Resistant Strains of Mycobacterium tuberculosis and other Naturally Resistant Mycobacteria In Vitro and Ex Vivo within Macrophages. Antimicrob. Agents Chemother., 59 (12): 7693-7699. DOI:10.1128/AAC.00936-15

Ribeiro, I., Faustino, C. (2015). Phospholipid-based drug delivery systems: scopes and limitations. In: Lecithins and Phospholipids: Biochemistry, Properties and Clinical Significance. J. Hernandez (Ed.), Biochemistry Research Trends, Nova Science Publishers: New York, pp.

Rosatella, A. A., and Afonso, C. A. M. (2015) Metal-Catalyzed Oxidation of C-X (X = S, O) in Ionic Liquids, In Ionic Liquids (Dupont, J., and Kollar, L., Eds.), pp 163-184.

 

Antonio, J. P. M., Frade, R. F. M., Santos, F. M. F., Coelho, J. A. S., Afonso, C. A. M., Gois, P. M. P., & Trindade, A. F. (2014). NHC catalysed direct addition of HMF to diazo compounds: synthesis of acyl hydrazones with antitumor activity. RSC Advances, 4(55), 29352–29356. doi:10.1039/C4RA03710C

Carrasco, M. P., Newton, A. S., Gonçalves, L., Góis, A., Machado, M., Gut, J., … Moreira, R. (2014). Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity. European Journal of Medicinal Chemistry, 80, 523–534. doi:10.1016/j.ejmech.2014.04.076

Coelho, J. A. S., Trindade, A. F., André, V., Teresa Duarte, M., Veiros, L. F., & Afonso, C. A. M. (2014). Trienamines derived from 5-substituted furfurals: remote ε-functionalization of 2,4-dienals. Org. Biomol. Chem., 12, 9324–9328. doi:10.1039/C4OB01759E

Ferreira, J. P., Viveiros, R., Lourenco, A., Silva, M. S. da, Rosatella, A., Casimiro, T., & Afonso, C. A. M. (2014). Integrated desulfurization of diesel by combination of metal-free oxidation and product removal by molecularly imprinted polymers. RSC Advances, 4(98), 54948–54952. doi:10.1039/C4RA11666F

Ferreira, M. J. U., Duarte, N., Reis, M., Madureira, A. M., & Molnár, J. (2014). Euphorbia and Momordica metabolites for overcoming multidrug resistance. Phytochemistry Reviews, 1–21. doi:10.1007/s11101-014-9342-8

Ferreira, R. J., Ferreira, M. J. U., & Santos, D. J. V. A. (2014). Reversing cancer multidrug resistance: Insights into the efflux by ABC transports from in silico studies. Wiley Interdisciplinary Reviews: Computational Molecular Science, 5(February), 27–55. doi:10.1002/wcms.1196

Frade, R. F. M., Coelho, J. A. S., Simeonov, S. P., & Afonso, C. A. M. (2014). An emerging platform from renewable resources: selection guidelines for human exposure of furfural-related compounds. Toxicology Research, 3(5), 311–314. doi:10.1039/C4TX00019F

Frija, L. M. T., & Afonso, C. A. M. (2014). Supported acid-catalyzed flash vacuum thermolysis on the valorisation of labdanum resin. Biomass and Bioenergy, 71, 363–369. doi:10.1016/j.biombioe.2014.09.020

Griffiths, K., Sharma, K., Marcos, P. M., Ascenso, J. R., Nind, J., Cottet, K., & Cragg, P. J. (2014). Cation binding, transport and theoretical calculations of   cone – p-tert -butylhexahomotrioxacalix[3]arene tris(acetic acid). Supramolecular Chemistry, 27(February), 167–173. doi:10.1080/10610278.2014.918269

Madeira, P. J. A., Sitoe, A. R. F., Gonçalves, D., Rodrigues, T., Guedes, R. C., Lopes, F., … Bronze, M. R. (2014). Antiplasmodial Drugs in the Gas Phase: A CID and DFT Study of Quinolon-4(1H)-Imine Derivatives. Journal of The American Society for Mass Spectrometry, 25(9), 1650–1661. doi:10.1007/s13361-014-0940-x

Mansoor, T. A., Borralho, P. M., Luo, X., Mulhovo, S., Rodrigues, C. M., Ferreira, M. J. F. (2014). 6-Acetonyldihydrochelerythrine Is a Potent Inducer of Apoptosis in HCT116 and SW620 Colon Cancer Cells. Nat. Prod., 77(8), 1825–1830. DOI: 10.1021/np500161n.

Marcos, P. M., Teixeira, F. A., Segurado, M. A P., Ascenso, J. R., Bernardino, R. J., Michel, S., & Hubscher-Bruder, V. (2014). Bidentate urea derivatives of p-tert-butyldihomooxacalix[4]arene: Neutral receptors for anion complexation. Journal of Organic Chemistry, 79, 742–751. doi:10.1021/jo4026012

Marcos, P. M., Teixeira, F. A., Segurado, M. A. P., Ascenso, J. R., Bernardino, R. J., Brancatelli, G., & Geremia, S. (2014). Synthesis and anion binding properties of new dihomooxacalix[4]arene diurea and dithiourea receptors. Tetrahedron, 70, 6497–6505. doi:10.1016/j.tet.2014.07.020

Martins, A. N. C., Simeonov, S. P., Frija, L. M. T., Viveiros, R., Lourenço, A., Silva, M. S. da, … Afonso, C. A. M. (2014). Isolation, analytical quantification and seasonal variation of labdanolic acid from the Portuguese-grown Cistus ladaniferus. Industrial Crops and Products, 60, 226–232. doi:10.1016/j.indcrop.2014.06.012

Mendes, E., Perry, M. D. J., & Francisco, A. P. (2014a). Design and discovery of mushroom tyrosinase inhibitors and their therapeutic applications. Expert Opinion on Drug Discovery, 9(5), 533–554. doi:10.1517/17460441.2014.907789

Mendes, E., Perry, M. de J., & Francisco, A. P. (2014b). Design and discovery of mushroom tyrosinase inhibitors and their therapeutic applications. Expert Opinion on Drug Discovery, 9(5), 533–554. doi:10.1517/17460441.2014.907789

Miranda, D., Capela, R., Albuquerque, I. S., Meireles, P., Paiva, I., Nogueira, F., … Lopes, F. (2014). Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities. ACS Medicinal Chemistry Letters, 5, 108–112. doi:10.1021/ml4002985

Pereira, N. A. L., & Santos, M. M. M. (2014). Antagonistas do receptor NMDA: três décadas de evolução no combate às doenças neurodegenerativas. Química, 135, 55–62.

Pereira, N. A. L., Sureda, F. X., Esplugas, R., Pérez, M., Amat, M., & Santos, M. M. M. (2014). Tryptophanol-derived oxazolopiperidone lactams: Identification of a hit compound as NMDA receptor antagonist. Bioorganic and Medicinal Chemistry Letters, 24(15), 3333–3336. doi:10.1016/j.bmcl.2014.05.105

Pires, E., Rosa, M., Gut, J., Rosenthal, P. J., & Prude, M. (2014). Tetraoxane − Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials. doi:10.1021/jm5004528

Oliveria, R., Guedes, R., Meireles, P., Albuquerque, I., Gonçalves, L., Pires, E., et al. (2014). Tetraoxane-Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials. J. Med. Chem., 57, 4916–4923.

Ramalhete, C., Da Cruz, F. P., Mulhovo, S., Sousa, I. J., Fernandes, M. X., Prudêncio, M., & Ferreira, M. J. U. (2014). Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite. Bioorganic and Medicinal Chemistry, 22, 3887–3890. doi:10.1016/j.bmc.2014.06.019

Reis, M. A., Paterna, A., Ferreira, R. J., Lage, H., & Ferreira, M. J. U. (2014). Macrocyclic diterpenes resensitizing multidrug resistant phenotypes. Bioorganic and Medicinal Chemistry, 22(14), 3696–3702. doi:10.1016/j.bmc.2014.05.006

Ribeiro, C. J. A., Amaral, J. D., Rodrigues, C. M. P., Moreira, R., & Santos, M. M. M. (2014). Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents. Bioorganic and Medicinal Chemistry, 22(1), 577–584. doi:10.1016/j.bmc.2013.10.048

Rijo, P., Duarte, A., Francisco, A. P., Semedo-Lemsaddek, T., & Simões, M. F. (2014). In vitro antimicrobial activity of royleanone derivatives against gram-positive bacterial pathogens. Phytotherapy Research, 28, 76–81. doi:10.1002/ptr.4961

Rijo, P., Falé, P. L., Serralheiro, M. L., Simões, M. F., Gomes, A., & Reis, C. (2014). Optimization of medicinal plant extraction methods and their encapsulation through extrusion technology. Measurement, 58, 249–255. doi:10.1016/j.measurement.2014.08.045

Rijo, P., Matias, D., Fernandes, A. S., Simões, M. F., Nicolai, M., & Reis, C. P. (2014). Antimicrobial plant extracts encapsulated into polymeric beads for potential application on the skin. Polymers, 6, 479–490. doi:10.3390/polym6020479

Santos, E., Albo, J., Rosatella, A., Afonso, C. A. M., & Irabien, Á. (2014). Synthesis and characterization of Magnetic Ionic Liquids (MILs) for CO 2 separation. Journal of Chemical Technology & Biotechnology, 89(May 2013), 866–871. doi:10.1002/jctb.4323

Santos, M. M. M. (2014). Recent advances in the synthesis of biologically active spirooxindoles. Tetrahedron, 70(52), 9735–9757. doi:10.1016/j.tet.2014.08.005

Scovazzo, P., Portugal, C. A. M., Rosatella, A. A., Afonso, C. A. M., & Crespo, J. G. (2014). Hydraulic pressures generated in Magnetic Ionic Liquids by paramagnetic fluid/air interfaces inside of uniform tangential magnetic fields. Journal of Colloid and Interface Science, 428, 16–23. doi:10.1016/j.jcis.2014.04.023

Silva, F. A., Siopa, F., Figueiredo, B. F. H. T., Gonçalves, A. M. M., Pereira, J. L., Gonçalves, F., … Ventura, S. P. M. (2014). Sustainable design for environment-friendly mono and dicationic cholinium-based ionic liquids. Ecotoxicology and Environmental Safety, 108, 302–310. doi:10.1016/j.ecoenv.2014.07.003

Trindade, A. F., Frade, R. F. M., Maçôas, E. M. S., Graça, C., Rodrigues, C. A. B., Martinho, J. M. G., & Afonso, C. A. M. (2014). “Click and go”: simple and fast folic acid conjugation. Organic & Biomolecular Chemistry, 12, 3181–90. doi:10.1039/c4ob00150h

Vieira, C., Duarte, N., Reis, M. A., Spengler, G., Madureira, A. M., Molnár, J., & Ferreira, M. J. U. (2014). Improving the MDR reversal activity of 6,17-epoxylathyrane diterpenes. Bioorganic & Medicinal Chemistry, 22, 6392–6400. doi:10.1016/j.bmc.2014.09.041

Zancajo, V. M. R., Brito, J., Carrasco, M. P., Bronze, M. R., Moreira, R., & Lopes, A. (2014). Analytical profiles of “legal highs” containing cathinones available in the area of Lisbon, Portugal. Forensic Science International, 244, 102–110. doi:10.1016/j.forsciint.2014.08.010

Patentes

Saraiva, L. H. A., Santos, M. M., Pereira, N. A. L., Pereira, C. I. F., Moreira, S. G., Leão, M. V. C. F., … Soares, J. O. G. (2014, December 31). Tryptophanol-derived oxazoloisoindolinones: small-molecule p53 activators.

 

Burmistrova O, Simões MF, Rijo P, Quintana J, Bermejo J, Estevez F. Antiproliferative activity of abietane diterpenoids in human tumor cells. J. Nat. Prod. 2013;76(8):1413–1423.

Carreiras MC, Mendes E, Perry M J, Francisco A P, Marco-Contelles J. The multifactorial nature of Alzheimer’s disease for developing potential therapeutics. Curr. Top. Med. Chem. 2013;13(15):1745-1770.

Ferreira RJ, Ferreira MJU, dos Santos DJVA. Assessing the stabilization of P-glycoprotein’s nucleotide-binding domains by the linker, using molecular dynamics. Mol Inf 2013;32(5-6): 529-40.

Ferreira RJ, Ferreira MJU, dos Santos DJVA. Molecular Docking characterizes substrate-binding sites and efflux modulation mechanisms within P-glycoprotein. J Chem Inf Model. 2013;53(7):1747-60.

Guerra KP and Afonso CAM, Synthetic survey and activity of 2′-deoxy-methanocarba nucleosides. Curr Org Synth 2013;10(2):210-240.

Juárez-Jimenez J, Mendes E, Galdeano C, Martins C, Silva DB, Marco-Contelles J, Carreiras MC, Luque FJ, Ramsay RR. Exploring the structural basis of the selective inhibition of monoamine oxidase A by dicarbonitrile aminoheterocycles: Role of Asn181 and Ile335 validated by spectroscopic and computational studies. Biochim Biophys Acta. Epub ahead of print 15 Nov 2013. DOI: 10.1016/j.bbapap.2013.11.003.

Lavrado J, Borralho PM, Ohnmacht SA, Castro RE, Rodrigues CMP, Moreira R, dos Santos DJVA, Neidle S, Paulo A. Synthesis, G-Quadruplex Stabilisation, Docking Studies and Effect on Cancer Cells of Indolo[3,2-b]quinolines with One, Two, or Three Basic Side Chains. Chem Med Chem. 2013;8:1648-61.

Luo X, Pires D, Aínsa JA, Gracia B, Duarte N, Mulhovo S, Anes E, Ferreira MJU. Zanthoxylum capense constituents with antimycobacterial activity against Mycobacterium tuberculosis in vitro and ex vivo within human macrophages. J Ethnopharmacol. 2013;146(1):417-22.

Mansoor TA, Borralho PM, Luo X, Mulhovo S, Rodrigues CM, Ferreira MJU. Monoterpene bisindole alkaloids, from the African medicinal plant Tabernaemontana elegans, induce apoptosis in HCT116 human colon carcinoma cells. J Ethnopharmacol. 2013;149(2):463-70.

Mansoor TA, Borralho PM, Luo X, Mulhovo S, Rodrigues CM, Ferreira MJU. Apoptosis inducing activity of benzophenanthridine-type alkaloids and 2-arylbenzofuran neolignans in HCT116 colon carcinoma cells. Phytomedicine. 2013;20(10):923-9.

Matos, A.M., & Francisco, A.P. (2013). Targets, structures, and recent approaches in malignant melanoma chemotherapy. Chem Med Chem, 8, 1751-1765 doi: 10.1002/cmdc.201300248

Mendes SAC, Mansoor TA, Rodrigues A, Armas JB, Ferreira MJU.  Anti-inflammatory guaiane-type sesquiterpenes from the fruits of Pittosporum undulatum. Phytochemistry 2013. Epub 2013 Jul 28, pii: S0031-9422(13)00247-1 doi: 10.1016/j.phytochem.2013.06.019

Monteiro AS, Almeida J, Cabral G, Severino P, Videira AP, Sousa A, Nunes R, Pereira JD, Francisco AP, Perry MJ , Mendes E. “Synthesis and evaluation of N-acylamino acids derivatives of triazenes”. Activation by tyrosinase in human melanoma cell lines”. Eur J Med Chem. 2013.in press

Oliveira R, Newton AS, Guedes RC, Miranda D, Amewu RK, Srivastava A, Gut J, Rosenthal PJ, O’Neill PM, Ward SA, Lopes F, Moreira R. An Endoperoxide-Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites. Chem Med Chem 2013;8(9):1528–1536.

Paula M. Marcos, Carla S. Proença, Filipa A. Teixeira, José R. Ascenso, Raul J. Bernardino, Peter J. Cragg, “Synthesis, NMR and DFT conformational studies of homooxacalixarene (cyanoprpyl)oxy derivatives, precursors to urea-terminated compounds”, Tetrahedron 2013, 69 (35), 7430-7437.

Paula M. Marcos, Filipa A. Teixeira, Manuel A. P. Segurado, José R. Ascenso, Raul J. Bernardino, Peter J. Cragg, Sylvia Michel, Véronique Hubscher-Bruder, Françoise Arnaud-Neu, “Complexation and DFT Studies of Lower Rim Hexahomotrioxacalix[3]arene Derivatives Bearing Pyridyl Groups with Transition and Heavy Metal Cations.Cone versus Partial Cone Conformation”, J. Phys. Org. Chem. 2013, 26, 295-305.

Paula M. Marcos, Filipa A. Teixeira, Manuel A. P. Segurado, José R. Ascenso, Raul J. Bernardino, Peter J. Cragg, Sylvia Michel, Véronique Hubscher-Bruder, Françoise Arnaud-Neu, ”Complexation and DFT Studies of Lanthanide Ions by (2-Pyridylmethoxy)-Homooxacalixarene Derivatives”, Supramol. Chem. 2013, 25 (8), 522-532.

Prigol M, Nogueira C W, Zeni G, Bronze MR, Constantino L. Physicochemical and biochemical profiling of diphenyl diselenide. Appl Biochem Biotechnol. 2013;169:885-93. doi: 10.1007/s12010-012-0042-9.

Reis MA, Ferreira RJ, Santos MM, Dos Santos DJ, Molnár J, Ferreira MJU. Enhancing macrocyclic diterpenes as multidrug-resistance reversers: structure-activity studies on jolkinol D derivatives. J Med Chem. 2013;56(3):748-60.

Ribeiro IA, Bronze MR, Castro MF, Ribeiro MHL. Sophorolipids: improvement of the selective production by Starmerellabombicola through the design of nutritional requirements. Appl Microbiol Biotechnol. 2013; 97(5): 1875-1887.

Ribeiro IA, Bronze MR, Castro MF, Ribeiro MHL. Sophorolipids: improvement of the selective production by Starmerellabombicola through the design of nutritional requirements. Appl Microbiol Biotechnol. 2013;97(5):1875-1887.

Rijo P, Duarte A, Francisco AP, Semedo-Lemsaddek T, Simões MF. In vitro Antimicrobial Activity of Royleanone Derivatives Against Gram-Positive Bacterial Pathogens. Phytother. Res. Epub 2013 Mar 11. doi: 10.1002/ptr.4961.

Santos SA, Paulo A. Small Molecule Inhibitors of Multidrug Resistance Gene (MDR1). Expression: Preclinical Evaluation and Mechanisms of Action. Current Cancer Drug Targets. 2013;13:814-828.

Silva D, ChiouaM, Samadi A, Agostinho P, GarçãoP, Lajarín-CuestaR, de los RíosC, IriepaI, MoraledaI, Gonzalez-LafuenteL, MendesE, PérezC, Rodríguez-Franco, MI, Marco-Contelles, J, CarreirasMC. Synthesis, Pharmacological assessment and Molecular modeling of Acetylcolinesterase/butyrylcholinesterase inhibors: Effect against amyloid-beta – induced neurotoxicity. ACS Chem. Neurosci. 2013;4:547-565.

Sousa IJ, Ferreira MJU, Molnár J, Fernandes MX. QSAR studies of macrocyclic diterpenes with P-glycoprotein inhibitory activity. Eur J Pharm Sci. 2013;48(3): 542–53

Books and book chapters

Faustino CMC, Calado ART, Garcia-Rio L. Micelles from Lipoamino Acids. In: Micelles: Structural Biochemistry, Formation and Functions & Usage. Nova Science Publishers; 2013 (in press).

Ribeiro IA, Castro MF, Ribeiro MHL. Sophorolipids: production, characterization and biologic activity. In: Gupta VK, Schmoll M, Maki M, Tuohy M, Mazutti MA, editors. Applications of Microbial Engineering. Boca Raton: CRC Press, Taylor & Francis; 2013. p. 367-407.

Rijo P, Faustino C, Simões MF. Antimicrobial natural products from Plectranthus plants. In: A. Méndez-Vilas editor. Microbial pathogens and strategies for combating them: science, technology and education. Badajoz: Formatex Research Center; 2013 (in press).

Conference Proceedings

Luo X, Pires D, Aínsa JA, Gracia B, Duarte N, Mulhovo S, Anes E, Ferreira MJU. Searching for natural antituberculars from Mozambican medicinal plants. Atas do Congresso Internacional Saber Tropical em Moçambique: História, Memória e Ciência Instituto de Investigação Cientifica Tropical, Lisboa, 2013, p1-10. ISBN 978-989-742-006-1.

Calado, S., Pereira, J., Eleuterio, C., Mendes, E., Francisco, A.P., Perry, M.J., & Gaspar, M.M. (2013). Nanoformulations with specific affinity to human melanoma. In proceedings of the 18th Meeting of the European Society for Pigment Cell Research Lisbon, Portugal, 9–12 September. Pigment Cell & Melanoma Research, 26(5), 603-783. doi: 10.1111/pcmr.12152

 

Albo J, Santos E, Neves LA, Simeonov SP, Afonso CAM, Crespo JG, Irabien A. Separation performance of CO2 through Supported Magnetic Ionic Liquid Membranes (SMILMs). Separation and Purification Technology. 2012, 97, 26-33. (IF = 2.921). DOI: 10.1016/j. seppur.2012.01.034.

Cal PM, Vicente JB, Pires E, Coelho AV, Veiros LF, Cordeiro C, Gois PM. Iminoboronates: a new strategy for reversible protein modification. J Am Chem Soc. 2012, 134: 10299-10305. (IF = 9.907). DOI: 10.1021/ja303436y.

Candeias NR, Afonso CAM, Gois PMP. Making expensive dirhodium(II) catalysts cheaper: Rh(II) recycling methods. Org Biomol Chem. 2012;10:3357-3378. (IF = 3.696). DOI: 10.1039/C2OB06731E.

Candeias NR, Cal PMSD, Gois PMP. A sustainable protocol for the aqueous multicomponent Petasis-borono Mannich reaction. J Chem Edu. 2012;89:799-802. (IF = 0.739).DOI: 10.1021/ed200509q.

Candeias NR, Carias C, Gomes LFR, André V, Duarte M, Gois PMP, Afonso CAM. Asymmetric intramolecular C-H insertion of alfa-diazo acetamides in water by Dirhodium(II) catalysts derived from natural amino acids. Adv Synth Cat. 2012, 354, 2921-2927. (IF = 6.048). DOI: 10.1002/adsc.201200101.

Capucha V, Mendes E, Francisco AP, Perry MJ. Development of triazene prodrugs for ADEPT strategy: New insights into drug delivery system based on carboxypeptidase G2 activation. Bioorg Med Chem Lett. 2012, 22: 6903-6908. (IF = 2.554) DOI: 10.1016/j.bmcl.2012.09.029

Carmine Gaeta, Carmen Talotta, Francesco Farina, Filipa A. Teixeira, Paula M. Marcos, José R. Ascenso, Placido Neri, “Alkylammonium Cation Complexation into the Narrow Cavity of Dihomooxacalix[4]arene Macrocycle”, J. Org. Chem. 2012, 77,10285-10293.

Carvalho T, Augusto V, Brás AR, Lourenço NMT, Afonso CAM, Barreiros S, Correia NT, Vidinha P, Cabrita EJ, Dias CJ, Dionísio M, Roling B. Understanding the Ion Jelly Conductivity Mechanism, J Phys Chem B. 2012;116:2664−2676. (IF = 3.696). DOI: dx.doi.org/10.1021/jp2108768.

Cruz FP, Martin C, Buchholz K, LafuenteMonasterio MJ, Rodrigues T, Sönnichsen B, Moreira R, Gamo FJ, Marti M, Mota MM, Hannus M, Prudêncio M. High throughput drug screen targeted at Plasmodium liver stages identifies a potent multistage Antimalarial drug. J Inf Dis, 2012, 205: 1278-1286. (IF = 6.410). DOI: 10.1093/infdis/jis184.

Dias C, Testa B, Soveral G, Dias M, Constantino L. Development of a screening method to assess the effect of drugs on alcohol metabolism. Toxicol in vitro. 2012;26:1177–1180. (IF = 2.755). DOI: 10.1016/ j.tiv.2012.06.011

Dias T, Liu B, Jones P, Houghton PJ, Mota-Filipe H, Paulo A. Cytoprotective effect of Coreopsis tinctoria extracts and flavonoids on tBHP and cytokine-induced cell injury in pancreatic MIN6 cell. J Ethnopharmacol. 2012;139:485-92. (IF = 3.014). DOI: 10.1016/j.jep.2011.11.038.

Faustino CMC, Calado ART, Garcia-Rio L. Interactions between β-cyclodextrin and an amino acid-based anionic gemini surfactant derived from cysteine. J Colloid Interface Sci 2012;367(1):286-292.

Ferreira RJ, Ferreira MJU, dos Santos DJVA. Insights on P-Glycoprotein’s Efflux Mechanism Obtained by Molecular Dynamics Simulations. J Chem Theory Comput. 2012;8:1853-1864. (IF = 5.215). DOI: 10.1021/ct300083m.

Frija LMT, Afonso CAM. Amberlyst-15: a reusable heterogeneous catalyst for the dehydration of tertiary alcohols. Tetrahedron. 2012;68:7414-7421. (IF = 3.025). DOI: 10.1016/j.tet.2012.06.083.

Kevin Cottet, Paula M. Marcos, Peter J. Cragg, “Fifty Years of Oxacalix[3]arenes: a Review”, Beilstein J. Org. Chem. 2012, 8, 201-226.

Kulkarni PS, Neves LA, Coelhoso IM, Afonso CAM, Crespo JG. Supported Ionic Liquid Membranes for Removal of Dioxins from High-Temperature Vapor Streams, Environ Sci Technol. 2012, 46: 462–468. (IF = 5.228). DOI: 10.1021/es2024302.

Kumar SP, Glória PMC, Gonçalves LM, Gut J, Rosenthal PJ, Moreira R, Santos MMM. Squaric acid: a valuable scaffold for developing antimalarials?. Med. Chem. Commun. 2012, 3: 489-493. (IF = 2.800). DOI: 10.1039/C2MD20011B.

Lai B, Teixeira G, Moreira I, Correia AI, Duarte A, Madureira AM. Evaluation of the antimicrobial activity in species of a Portuguese “Montado” ecosystem against multidrug resistant pathogens. J Med Plants Res. 2012, 6: 1846-1852. (IF = 0.600). DOI: 10.5897/JMPR11.994.

Lavrado J, Mackey Z, Hansell E, McKerrow JH, Paulo A, Moreira R. Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives. Bioorg Med Chem Lett. 2012;22:6256-6260. (IF = 2.554) DOI: 10.1016/j.bmcl.2012.07.104

Lavrado J, Paulo A, Bichenkova E, Douglas KT, Moreira R. 1H NMR spectroscopic identification of protonable sites in cryptolepines with C-11-substituents containing two amino functionalities. Magn Reson Chem. 2012;50:216-220. (IF = 1.437) DOI: 10.1002/mrc.2873

Lucas SD, Gonçalves L, Cardote TAF, Moreira R, Guedes RC. Structure based virtual screening for discovery of novel human neutrophil elastase inhibitors. Med Chem Comm. 2012;3:1299-1304. (IF = 2.800). DOI: 10.1039/c2md20090b.

Luo X, Pedro L, Milic V, Mulhovo S, Duarte A, Duarte N, Ferreira MJU. Antibacterial Benzofuran Neolignans and Benzophenanthridine Alkaloids from the Roots of Zanthoxylum capense. Planta Med. 2012;78:148-153. (IF = 2.153). DOI: 10.1055/s-0031-1280289.

Madureira AM, Duarte A, Teixeira G. Antimicrobial activity of selected extracts from Hakea salicifolia and H. sericeae (Proteaceae) against Staphylococcus aureus multiresistant strains. South Afr J Bot. 2012;81:40-43. (IF = 1.655) DOI: 10.1016/j.sajb.2012.05.002.

Madureira AM, Ramalhete C, Mulhovo S, Duarte A, Ferreira, MJU. Antibacterial activity of some African medicinal plants used traditionally against infectious diseases. Pharm Biol. 2012, 50: 481-489 (IF = 0.878). DOI: 10.3109/13880209.2011.615841.

Mansoor TA, Ramalho RM, Rodrigues CMP, Ferreira MJU. Dibenzylbutane- and Butyrolactone-type Lignans as Apoptosis Inducers in Human Hepatoma HuH-7 Cells. Phytoth Res. 2012;26:692-696. (IF = 2.086). DOI: 10.1002/ptr.3629.

Mata G, Casimiro C, do Rosário VE, Constantino L, Moreira R. Carbamate Derivatives of Primaquine: Antimalarial Activity, Chemical Stability and Enzymatic Activation. Bioorg Med Chem. 2012, 20: 886-892. (IF = 2.921).

Matos APA, Vale FF, Vítor JMB. Helicobacter pylori association with amoeba: a natural reservoir of the bacteria? Microscopy and Microanalysis. 2012, 18: 27-28. (IF = 3.007). DOI: 10.1017/S1431927612012792.

Matos J, da Cruz FP, Cabrita E, Gut J, Nogueira F, do Rosário VE, Moreira R, Rosenthal P, Prudêncio M, Gomes P. New potent metallocenes against liver stage malaria. Antimicrob. Agents Chemother. 2012, 56: 1564-1570. (IF = 4.841). DOI: 10.1128/AAC.05345-11.

Montalbano F, Candeias NR, Veiros LF, André V, Duarte MT, Bronze MR, Moreira R, Gois PMP. Four-Component Assembly of Chiral N-B Heterocycles with a Natural Product-Like Framework. Org Lett. 2012, 14: 988-891. (IF = 5.862). DOI: 10.1021/o1203224n.

Piçarra S, Afonso CAM, Kurteva VB, Fedorov A, Martinho JMG, Farinha JPS. The influence of nanoparticle architecture on latex film formation and healing properties, Journal of Colloid and Interface Science. 2012, 368: 21–33. (IF = 3.070). DOI: 10.1016/j.jcis.2011.10.077.

Pimenta AFR, Baptista AC, Carvalho T, Brogueira P, Lourenço NMT, Afonso CAM, Barreiros S, Vidinha P, Borges JP. Electrospinning of Ion Jelly fibers. Material Letters. 2012, 83, 161-164. (IF = 2.307). DOI: 10.1016/j.matlet.2012.04.146.

Prigol M, Nogueira C W, Zeni G, Bronze MR, Constantino L. In vitro metabolism of diphenyl diselenide in rat liver fractions. Reaction with GSH and binding to thiol groups. Chem Biol Interact. 2012, 200: 65-72. (IF = 2.865). DOI: 10.1016/j.cbi.2012.09.007.

Ramalhete C, Magalhães LG, Rodrigues V, Mulhovo S, Da Silva Filho AA, Ferreira MJU. In vitro schistosomicidal activity of balsaminol f and karavilagenin C. Planta Med. 2012;78:1912-1917. (IF = 2.153). DOI: 10.1055/s-0032-1327832.

Reis M, Ferreira R, Serly J, Duarte N, Madureira A, Santos D, Molnár J, Ferreira MJU. Colon adenocarcinoma multidrug resistance reverted by Euphorbia diterpenes: structure-activity relationships and pharmacophore modeling. Anticancer Agents in Medicinal Chemistry. 2012, 12:1015-1024. (IF = 2.862). DOI: 10.3109/13880209.2011.615841

Ribeiro CJA, Kumar SP, Moreira R, Santos MMM. Efficient synthesis of spiroisoxazoline oxindoles. Tetrahedron Lett. 2012, 53:281-284. (IF = 2.618).DOI:10.1016/j.tetlet.2011.10.139.

Ribeiro IA, Bronze MR, Castro MF, Ribeiro MHL. Design of selective production of sophorolipids by Rhodotorula bogoriensis through nutritional requirements. J Mol Recognit. 2012; 25:630-640.

Ribeiro IA, Bronze MR, Castro MF, Ribeiro MHL. Design of selective production of sophorolipids by Rhodotorula bogoriensis through nutritional requirements. J Mol Recognit. 2012;25:630-640.

Ribeiro IA, Bronze MR, Castro MF, Ribeiro MHL. Optimization and correlation of HPLC-ELSD and HPLC-MS/MS methods for identification and characterization of sophorolipids. J Chromatogr B Analyt Technol Biomed Life Sci. 2012; 899:72– 80.

Ribeiro IA, Bronze MR, Castro MF, Ribeiro MHL. Optimization and correlation of HPLC-ELSD and HPLC-MS/MS methods for identification and characterization of sophorolipids. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;899:72– 80.

Rocha e Silva LF, Montoia A, Amorima RCN, Melo MR, Henrique MC, Nunomura SM, Costa MRF, Andrade Neto VF, Costa DS, Dantas G, Lavrado J, Moreira R, Paulo A, Pinto AC, Tadei WP, Zacardi RS, Eberlin MN, Pohlit AM. Comparative in vitro and in vivo antimalarial activity of the indole alkaloids ellipticine, olivacine, cryptolepine and a synthetic cryptolepine analog. Phytomedicine 2012, 20: 71-76. (IF = 3.268). DOI: 10.1016/j.phymed.2012.09.008

Rodrigues CAB, Mariz IFA, Maçôas EMS, Afonso CAM, Martinho JMG. Two-photon absorption properties of pushepull oxazolones derivatives. Dyes Pigments. 2012, 95: 713-722. (IF = 3.126). DOI: doi.org/10.1016/j.dyepig.2012.06.005.

Rodrigues T, Lopes F, Moreira R. Microwave-assisted wittig reaction of semistabilized nitro-substituted benzyltriphenyl-phosphorous ylides with aldehydes in phase¬transfer conditions, Syn Comm. 2012, 42: 747¬755. (IF = 0.937). DOI: 10.1080/00397911.2010.530378

Rodrigues T, Prudêncio M, Moreira R, Mota MM, Lopes F. Targeting the Liver Stage of Malaria Parasites: An Yet Unmet Goal. J Med Chem. 2012, 55, 995¬1012. (IF = 5.207). DOI: 10.1021/jm201095h

Santana AB, Lucas SD, Gonçalves LM, Correia HF, Cardote TAF, Guedes RC, Iley J, Moreira R. N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases. Bioorg Med Chem Lett. 2012, 22: 3993–3997. (IF = 2.554). DOI: 10.1016/j.bmcl.2012.04.093.

Simeonov SP, Coelho JAS, Afonso CAM. An Integrated Approach for the Production and Isolation of 5-Hydroxymethylfurfural from Carbohydrates. ChemSusChem. 2012, 5: 1388-1391. (IF = 6.827) DOI: 10.1002/cssc.201200236.

Sousa IJ, Ferreira MJU, Molnár J, Fernandes MX. QSAR studies of macrocyclic diterpenes with P-glycoprotein inhibitory activity. Eur J Pharm Sci. 2012. (IF = 3.212). DOI: pii: S0928-0987(12)00470-8. 10.1016/j.ejps.2012.11.012.

Teixeira G, Correia AI, Vasconcelos T, Duarte A, Oliveira N, Madureira AM. Lavandula stoechas subsp. luisieri and L. pedunculata: comparative antibacterial activity. J Phytoth Pharmacol. 2012;6:11-15. DOI: 6. 2012/RA-738-JPCOL.

Timoteo A, Breurec S, Oleastro M, Roxo-Rosa M, Vitor JMB,  Lehours P,Vale FF. Secreening of Prophage Sequences among Helicobater Isolates. Helicobacter. 2012, 17: 67-67. ISSN: 1083-4389.

Trindade A, Coelho JAS, Afonso CAM, Veiros LF, Gois PMP. Fine tuning of dirhodium(II) complexes: Exploring the axial modification. ACS Catal. 2012, 2: 370–383. DOI: 10.1021/cs200597a.

Vale N, Fernandes I, Moreira R, Mateus N, Gomes P. Comparative analysis of in vitro rat liver metabolism of the antimalarial primaquine and a derived imidazoquine. Drug Metabolism Letters. 2012, 6:15-20.

Vale-Costa S, Vale N, Tomás A, Moreira R, Gomes P, Gomes MS. Evaluation of dipeptide and peptidomimetic derivatives of primaquine against Leishmania infantum. Antimicrob. Agents Chemother. 2012, 56: 5774-5781. (IF = 4.841). DOI: 10.1128/AAC.00873-12

Valente I, Reis M, Duarte N, Serly J, Molnar J, Ferreira MJU. Jatrophane Diterpenes from Euphorbia mellifera and Their Activity as P-Glycoprotein Modulators on Multidrug-Resistant Mouse Lymphoma and Human Colon Adenocarcinoma Cells. J Nat Prod. 2012, 75: 1896-1902. (IF = 3.128). DOI: 10.1021/np3004003.

Ventura SPM, Marques CS, Rosatella A, Afonso C, Gonçalves F, Coutinho JAP. Toxicity assessment of various ionic liquid families towards Vibrio fischeri marine bacteria. Ecotoxicology and Environmental Safety. 2012;76:162–168. (IF = 2.294). DOI: 10.1016/j.ecoenv.2011.10.006.

Wesolowska O, Wisniewski J, Sroda-Pomianek K, Bielawska-Pohl A, Paprocka M, Dus D, Duarte N, Ferreira MJU, Michalak K. Multidrug Resistance Reversal and Apoptosis Induction in Human Colon Cancer Cells by Some Flavonoids Present in Citrus Plants. J Nat Prod. 2012, 75: 1915-1921. (IF = 3.128). DOI: 10.1021/np3003468.

Zakrzewskaa ME, Cal PMSD, Candeias NR, Bogel-Łukasik R, Afonso CAM, Ponte MN, Gois PMP. Intramolecular CH insertion catalyzed by dirhodium(II) complexes using CO2 as the reaction. Media, Green Chemistry Letters and Reviews. 2012, 5, 211-240. (IF = 0.976). DOI: http://dx.doi.org/10.1080/17518253.2011.620009.

Books and book chapters

Carreiras MC, Soriano E, Marco JL. Multipotent 1,8-Naphthyridines, as new tacrine analogues, for the treatment of Alzheimer’s disease. In: Bioactive Heterocycles: Synthesis and Biological Evaluation. Ameta KL, Pawar RP, Domb AJ (Eds). Nova Science Publishers, N.Y. 2012. ISBN:978-1-62257-636-4.

Ferreira MJU, Duarte N, Lage H, Molnár J. Reversal of multidrug resistance by macrocyclic and polycyclic diterpenoids from Euphorbia species. In: Govil JN and Kaushik G (Eds). Recent Progress in Medicinal Plants: Ethnomedicine and Therapeutic Validation. 2012, 32, Chapter 8: 193-213. Studium Press LLC. ISBN: 1-933699-22-1.

Trindade A, Gois PMP, Monteiro C, Afonso CAM. Catalytic Methods in Asymmetric Synthesis: Advanced Materials, Techniques, and Applications. Gruttadauria M, Wiley FG (Eds) 2012. Book chapter: Chapter 3. Recyclable stereoselective catalysts. 2012, 3-64. ISBN: 978-0-470-64136-1.

 

Almeida AR, Peixoto AF, Calvete MJF, Gois PMP, Pereira MM. Rhodium(I) N-heterocyclic Carbene Complexes as Catalysts for Hydroformylation of Olefins: an Overview. Curr Org Synth. 2011, 12: 764-775. (IF= 3.615). DOI: http://dx.doi.org/10.2174/157017911796957339.

Ascenso A, Guedes R, Bernardino R, Diogo H, Silva AM, Marques HC. Complexation and full characterization of tretinoin with dimethyl-beta-cyclodextrin. AAPS PharmSciTech. 2011, 12: 553-563. (IF = 1. 211). DOI: 10.1208/s12249-011-9612-3.

Capela R, Cabal GG, Rosenthal PJ, Gut J, Mota MM, Moreira R, Lopes F, Prudêncio M. Design and Evaluation of Primaquine-Artemisinin Hybrids as a Multistage Anti-Malarial Strategy. Antimicrob Agents Chemother. 2011, 55: 4698-4706. (IF = 4. 680). DOI: 10.1128/AAC.05133-11.

dos Santos DJVA, Saenz-Méndez P, Eriksson LA, Guedes RC. Properties and behaviour of tetracyclic allopsoralen derivatives inside a dppc lipid bilayer model. Phys Chem Chem Phys. 2011, 13: 10174–10182. (IF = 3.454). DOI: 10.1039/C0CP02245D.

Estácio SG, Moreira R, Guedes RC. Characterizing the dynamics and ligand specific interactions in the human leukocyte elastase through molecular dynamics simulations. J Chem Inf Model. 2011, 51: 1690-1702. (IF = 3.722). DOI: 10.1021/ci200076k.

Faustino CMC, Calado ART, Garcia-Rio L. Mixed micelle formation between amino acid-based surfactants and phospholipids. J Colloid Interface Sci 2011;359(2):493-498.

Ferreira RJ, dos Santos DJ, Ferreira MJ, Guedes RC. Toward a better pharmacophore description of P-glycoprotein modulators, based on macrocyclic diterpenes from Euphorbia species. J Chem Inf Model. 2011, 51: 1315-24. (IF = 3.822). DOI: 10.1021/ci200145p.

Frija LMT, Frade RFM, Afonso CAM. Isolation, Chemical and Bio-transformation Routes of Labdane-type Diterpenes. Chem Rev. 2011, 111: 4418-4452. (IF = 33.036). DOI: 10.1021/cr100258k.

Glória PMC, Coutinho I, Gonçalves LM, Baptista C, Soares J, Newton AS, Moreira R, Saraiva L, Santos MMM. Aspartic vinyl sulfones: inhibitors of a caspase-3-dependent pathway.  Eur J Med Chem. 2011, 46: 2141-2146. (IF = 3. 356). DOI: 10.1016/j.ejmech.2011.02.067.

Glória PMC, Gut J, Gonçalves LM, Rosenthal PJ, Moreira R, Santos MMM. Aza vinyl sulfones: synthesis and evaluation as antiplasmodial agents. Bioorg Med Chem. 2011, 19: 7635-7642. (IF = 3.108). DOI: 10.1016/j.bmc.2011.10.018.

Guerra KP, Afonso CAM. An efficient and simple Morita-Baylis-Hillman reaction based on the N-methylpyrrolidineeBa(OH)2 catalytic system. Tetrahedron. 2011, 67:2562-2569. (IF = 3.011). DOI:10.1016/j.tet.2011.02.020.

Guerra KP, Afonso CAM. Efficient tandem Morita Baylis Hillman-double cross-aldol reaction between cyclic enones and formaldehyde promoted by N-methylpyrrolidine. Eur J. Org Chem. 2011, 2372–2379. (IF = 3.206). DOI: 10.1002/ejoc.201001612.

Kumar SP, Gut J, Guedes RC, Rosenthal PJ, Santos MMM, Moreira R. Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials. Eur J Med Chem. 2011, 46:927-933. (IF = 3. 356).  DOI: 10.1016/j.ejmech.2011.01.008.

Lavrado J, Cabal G, Prudêncio M, Mota MM, Gut J, Rosenthal PL, Diaz C, Guedes RC, dos Santos DJVA, Bichenkova E, Douglas KT, Moreira R, Paulo A. Incorporation of Basic Side-Chains into Cryptolepine Scaffold. Structure-Antimalarial Activity Relationships and Mechanistic Studies. J Med Chem. 2011, 54:734-750. (IF = 5. 180). DOI: 10.1021/jm101383f.

Luo X, Pires D, Aínsa JA, Gracia B, Mulhovo S, Duarte A, Anes E, Ferreira MJ. Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique. J Ethnopharmacol. 2011, 137:114-20. (IF = 2. 466). DOI: 10.1016/j.jep.2011.04.062.

Mansoor TA, Ramalho RM, Luo X, Ramalhete C, Rodrigues CM, Ferreira MJ. Isoflavones as apoptosis inducers in human hepatoma HuH-7 cells. Phytother Res. 2011, 25: 1819-24. (IF = 1.878). DOI: 10.1002/ptr.3498.

Martins C, Carreiras MC, León R, de los Ríos C, Bartolini M, Andrisano V, Iriepa I, Moraleda I, Gálvez E, García M, Egea J, Samadi A, Chioua M, and Marco-Contelles J. Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues. Eur J Med Chem. 2011, 46: 6119-30. (IF = 3.193). DOI: 10.1016/j.ejmech.2011.09.038.

Mulchande J, Simões SI, Gaspar MM, Eleutério CV, Oliveira R, Cruz MEM, Moreira R, Iley J. Synthesis, Stability, Biochemical and Pharmacokinetic Properties of a New Potent and Selective 4-Oxo-beta beta-lactam Inhibitor of Human Leukocyte Elastase. J Enzym Inhib Med Chem. 2011, 26: 169-175. (IF = 1. 630). DOI: 10.3109/14756366.2010.486794.

Nunes JPM, Veiros LF, Vaz PD, Afonso CAM, Caddick S. Asymmetric synthesis of trans-4,5-dioxygenated cyclopentenone derivatives by organocatalyzed rearrangement of pyranones and enzymatic dynamic kinetic resolution. Tetrahedron 2011, 67: 2779-2787. (IF = 3.011). DOI: 10.1016/j.tet.2011.02.018.

Paula M. Marcos, José R. Ascenso, Manuel A. P. Segurado, Peter J. Cragg, Sylvia Michel, Véronique Hubscher-Bruder, Françoise Arnaud-Neu, “Lanthanide Cation Binding Properties of Homooxacalixarene Diethylamide Derivatives”, Supramol. Chem. 2011, 23 (1-2), 93-101.

Pérez M, Arioli F, Rigacci G, Santos MMM, Gómez-Esqué A, Escolano C, Florindo P, Ramos C, Bosch J, Amat M. Stereocontrolled Generation of Benzo[a]- and Indolo[2,3-a]quinolizidines from (S)-Tryptophanol and (S)-(3,4-Dimethoxyphenyl)alaninol Derived Lactams. Eur J Org Chem. 2011, 3858-3863. (IF = 3.206). DOI: 10.1002/ejoc.201100294.

Ramalhete C, da Cruz FP, Lopes D, Mulhovo S, Rosário VE, Prudêncio M, Ferreira MJ. Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections. Bioorg Med Chem. 2011, 19: 7474-81. (IF = 2. 978). DOI: 10.1016/j.bmc.2011.10.044.

Ramalhete C, Lopes D, Molnár J, Mulhovo S, Rosário VE, Ferreira MJ. Karavilagenin C derivatives as antimalarials. Bioorg Med Chem. 2011, 19:330-338.(IF = 2.978). DOI: 10.1016/j.bmc.2010.11.015.

Ramalhete C, Spengler G, Martins A, Martins M, Viveiros M, Mulhovo S, Ferreira MJ, Amaral L. Inhibition of efflux pumps in meticillin-resistant Staphylococcus aureus and Enterococcus faecalis resistant strains by triterpenoids from Momordica balsamina. Int J Antimicrob Agents. 2011, 37:70-74.  (IF = 3.787). DOI: 10.1016/j.ijantimicag.2010.09.011.

Reddy RS, Rosa JN, Veiros LF, Caddick S, Gois PMP. NHC/Iron cooperative catalysis: aerobic oxidative esterification of aldehydes with phenols. Org Biomol Chem. 2011, 9: 3126-3129. (IF = 3. 219). DOI: 10.1039/c1ob05151b.

Ressurreição ASM, Delatouche R, Gennari C, Piarulli U. Bifunctional 2,5-Diketopiperazines as Rigid Three-Dimensional Scaffolds in Receptors and Peptidomimetics. Eur J Org Chem. 2011, 217 – 218. (IF = 3. 206). DOI: 10.1002/ejoc.201001330.

Rijo P, Rodríguez B, Duarte A, Simões MF. Antimicrobial properties of Plectranthus ornatus extracts, 11-acetoxyhalima-5,13-dien-15-oic acid metabolite and its derivatives. The Natural Products Journal. 2011, 1: 57-64. (IF = N/ A). DOI: 10.2174/2210316311101010057.

Rodrigues T, dos Santos DJVA, Moreira R, Lopes F, Guedes RC. A quantum mechanical study of novel potential inhibitors of cytochrome bc (1) as antimalarial compounds. Int J Quantum Chem. 2011, 111: 1196-1207. DOI: 10.1002/qua.22741. (IF = 1. 305).

Rodrigues T, Moreira R, Gut J, Rosenthal PJ, O’Neill PM, Biagini GA, Lopes F, dos Santos DJVA, Guedes RC. Identification of new antimalarial leads by use of virtual screening against cytochrome bc1. Bioorg Med Chem. 2011, 19: 6302-6308. (IF = 3.108). DOI: 10.1016/j.bmc.2011.09.004.

Rodrigues T, Moreira R, Lopes F. New hope in the fight against malaria? Future Med Chem. 2011, 3: 1-3. (IF = 1. 424). DOI: 10.4155/FMC.10.274.

Rosatella AA, Afonso CAM, Branco LC. Oxidation of cyclohexene to trans-1,2-cyclohexanediol promoted by p-toluenesulfonic acid without organic solvents. J Chem Educ. 2011, 88: 1002-1003. (IF = 0. 571). DOI: 10.1021/ed1006772.

Rosatella AA, Afonso CAM. Brønsted Acid-Catalyzed Dihydroxylation of Olefins in Aqueous Medium. Adv Synth Catal. 2011, 353: 2920 – 2926. (IF = 5. 250). DOI: 10.1002/adsc.201100187.

Rosatella AA, Frade RFM, Afonso CAM. Dissolution and Transformation of Carbohydrates in Ionic Liquids. Curr Org Synth. 2011, 8: 840-860. (IF= 3.952).

Rosatella AA, Simeonov SP., Frade RFM, Afonso CAM. 5-Hydroxymethylfurfural (HMF) as a Building Block Platform: Biological Properties, Synthesis and Synthetic Applications. Green Chem. 2011, 13: 754-793. (IF = 5. 472). DOI: 10.1039/C0GC00401D.

Samadi A, Silva DB, Chioua M, Carreiras MC, Marco-Contelles J. Microwave irradiation-assisted amination of 2-chloropyridine derivatives with amide solvents. Synth Commun. 2011, 41: 2859-69. (IF = 0. 937). DOI: 10.1080/00397911.2010.515360.

Santos MMM. Caspases como alvo terapêutico para o tratamento de doenças neurodegenerativas. Química, Boletim da Sociedade Portuguesa de Química. 2011, 121: 47-51.

Silva DB, Chioua M, Samadi A, Carreiras MC, Jimeno ML, Mendes E, de los Ríos C, Romero A, Villarroya M, López MG, Marco-Contelles J. Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives. Eur J Med Chem. 2011, 46: 4676-81. (IF = 3. 193). DOI: 10.1016/j.ejmech.2011.05.068.

Sucunza D, Samadi A, Chioua M, Silva DB, Yunta C, Infantes L, Carreiras MC, Soriano E, Marco-Contelles J. A practical two-step synthesis of imidazo[1,2-a]pyridines from N-(prop-2-yn-1-yl)pyridin-2-amines. Chem Commun. 2011, 47: 5043-45. (IF= 5. 787). DOI: 10.1039/c1cc10641d.

Tan B, Candeias NR, Barbas CF. Construction of bispirooxindoles containing three quaternary stereocentres in a cascade using a single multifunctional organocatalyst. Nat Chem. 2011, 3: 473-477. (IF = 17. 927). DOI: 10.1038/nchem.1039.

Tan B, Candeias NR, Barbas CF. Core-Structure-Motivated Design of a Phosphine-Catalyzed [3+2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles. J Am Chem Soc. 2011, 133: 4672-4675. (IF = 9. 023). DOI: 10.1021/ja110147w.

Valente E, Simões MF, Testa B, Constantino L. Development of a method to investigate the hydrolysis of xenobiotic esters by a Mycobacterium smegmatis homogenate. J Microbiol Methods 2011, 85: 98-102. (IF = 2. 470). DOI 10.1016/j.mimet.2011.02.003.

Vila-Real H, Alfaia A, Rosa J, Gois PMP, Rosa ME, Calado A, Ribeiro MH. Alpha-Rhamnosidase and b-glucosidase expressed by naringinase immobilized on new ionic liquid sol-gel matrices: Activity and stability studies. J Biotech. 2011, 110: 6169. (IF = 2.881). DOI: 10.1016/j.jbiotec.2010.08.005.

Vítor J, Vale F. Alternative therapies for Helicobacter pylori: probiotics and phytomedicine. FEMS Immunol Med Microbiol. 2011, 63:153–164. (IF = 2. 494). DOI: 10.1111/j.1574-695X.2011.00865.x.

Books and book chapters

Afonso CAM, Simão DP, Ferreira LP, Serra MES, Raposo MMM. 100 Experiências de Química Orgânica. IST Press. 2011. ISBN: 978- 989-8481-09-2.

Ferreira MJ, Duarte N, Michalak K, Varga A, Molnár J. Euphorbia seeds: Piceatannol, an antitumor compound from Euphorbia lagascae. In: Preedy VR, Watson RR, Vatel VB (Eds). Nuts & Seeds in Health and Disease Prevention (1st ed.). San Diego: Academic Press. 2011, 453-460. ISBN: 9780123756886.

Kulkarni PS, Crespo JP, Afonso CAM. Dioxins. In: Encyclopedia of Environmental Health. Nriagu JO (ed.). Burlington, Elsevier. 2011, 2: 83–92. ISBN 10: 0-444-52273-5. ISBN-13: 978-0444522634.

Lavrado J, Moreira R, Paulo A. Synthetic strategies towards bioactive indolo[3,2-b]quinolines. In: Heterocyclic Targets in Advanced Organic Synthesis. Carreiras MC, Marco-Contelles J (Eds). Research Signpost. 2011, 109-124. ISBN: 978-81-308-0431-6.

Mendes E, Perry MJ, Francisco AP. The synthetic utility of triazenes in heterocyclic synthesis. In: Carreiras MC, Marco-Contelles, J (eds). Heterocyclic Targets in Advanced Organic Synthesis Transworld Research Network, Kerala, India. 2011, 125-144. ISBN-1: 978-81-308-0431-6.

Monteiro CM, Trindade AF, Góis PMP, Afonso CAM. Recyclable Stereoselective Catalysis. In: Catalytic Methods in Asymmetric Synthesis: Advanced Materials, Techniques and Applications. Gruttadauria M, Giacalone F (Eds). Wiley. 2011, chapter 1: 3-82. ISBN: 978-0-470-64136-1.

Mulchande J, Lopes F, Moreira R. Azetidin-2-ones and related systems as enzyme inhibitors: synthesis and reactivity. In: Heterocyclic Targets in Advanced Organic Synthesis. Carreiras MC, Marco-Contelles J (Eds). Research Signpost. 2011. ISBN: 978-81-308-0431-6.

Santos MMM. Tryptophanol-Derived Oxazolopiperidone Lactams: Valuable Building Blocks for the Enantioselective Synthesis of Piperidine-Containing Alkaloids. In: Heterocyclic Targets in Advanced Organic Synthesis. M. C. Carreiras, J. Marco-Contelles (Eds). Research Signpost, Trivandrum, Kerala, India. 2011, 69-82. ISBN-1: 978-81-308-0431-6.

 

Bui T, Candeias NR, Barbas CF. Dimeric Quinidine‐Catalyzed Enantioselective Aminooxygenation of Oxindoles: An Organocatalytic Approach to 3‐Hydroxyoxindole Derivatives. J Am Chem Soc. 2010, 132: 5574-5475. (IF = 8.580).

Candeias NR, Cal PMSD, Andre V, Duarte MT, Veiros LF, Gois PMP. Water as the reaction medium for multicomponent reactions based on boronic acids. Tetrahedron. 2010, 66: 2736–2745. (IF = 3.219).

Candeias NR, Montalbano F, Cal PMSD, Gois PMP. Boronic acids and esteres in the Petasis-Borono Mannich multicomponent reaction. Chem Rev. 2010, 110: 6169-6193. (IF = 35.957).

Candeias NR. Carbenos em Água: Reactivos, mas pouco (Carbenes in water: a mediated reactivity). Química – Boletim da Sociedade Portuguesa de Química (Magazine of the Portuguese Chemical Society). 2010, 118: 35-39.

Castro RE, Santos MMM, Glória PMC, Ribeiro CJA, Ferreira DMS, Xavier JM, Moreira R, Rodrigues CMP. Cell Death Targets and Potential Modulators in Alzheimer’s Disease. Curr Pharm Design. 2010, 16: 2710-2723. (IF = 4. 414).

Dias T, Bronze MR, Houghton PJ, Mota-Filipe H, Paulo A. The flavonoid-rich fraction of Coreopsis tinctoria promotes glucose tolerance regain through pancreatic function recovery in streptozotocin-induced glucose-intolerant rats. J. Ethnopharmacol. 2010, 132: 483-490. (IF = 2.322).

Dias T, Mota-Filipe H, Liu B, Jones P, Houghton PJ, Paulo A. Recovery of oral glucose tolerance by Wistar rats after treatment with Coreopsis tinctoria infusion. Phytother Res. 2010, 24: 699-705. (IF = 1.746).

Duarte N, Lage H, Abrantes M, Ferreira MJ. Phenolic compounds as selective antineoplasic agents against multidrug-resistant human cancer cells. Planta Med. 2010, 76: 975-980. (IF = 2.037).

Faustino CMC, Calado ART, Garcia-Rio L. Dimeric and monomeric surfactants derived from sulfur-containing amino acids. J Colloid Interface Sci 2010;351(2):472-477.

Frade RFM, Candeias NR, Duarte CMM, André V, Duarte MT, Gois PMP, Afonso CAM. New dirhodium complex with activity towards colorectal cancer. Bioorg Med Chem Lett. 2010, 20: 3413–3415. (IF = 2.650).

Gibbons P, Verissimo E, Araujo NC, Barton V, Nixon GL, Amewu RK, Chadwick J, Stocks PA, Biagini GA, Srivastava A, Rosenthal PJ, Gut J, Guedes RC, Moreira R, Sharma R, Berry N, Cristiano MLS, Shone AE, Ward SA, O’ Neill PM. Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotheraphy of Malaria through a Single Chemical Entity. J Med Chem. 2010, 53: 8202-8206. (IF = 4. 802).

Kolaczkowski M, Kolaczkowska A, Sroda K, Ramalhete C, Michalak K, Mulhovo S, Ferreira MJ. Substrates and modulators of the multidrug transporter Cdr1p of Candida albicans in antifungal extracts of medicinal plants. Mycoses. 2010, 53: 305-310. (IF = 1.402).

Kulkarni PS, Afonso CAM. Deep desulfurization of diesel fuel using ionic liquids: current status and future challenges. Green Chem. 2010, 12: 1139-1149. (IF = 5.836).

Kulkarni PS, Brazinha C, Afonso CAM, Crespo JG. Selective extraction of natural products with benign solvents and recovery by organophilic pervaporation: fractionation of D-limonene from orange peels. Green Chem. 2010, 12: 1990-1994. (IF = 5.836).

Lage H, Duarte N, Coburger C, Hilgeroth A, Ferreira MJ. Antitumor activity of terpenoids against classical and atypical multidrug resistant cancer cells. Phytomedicine. 2010, 17: 441-448. (IF = 2.174).

Lavrado J, Gani K, Nobre PA, Santos SA, Lopes D, Rosário V, Gut J, Rosenthal PJ, Moreira R, Paulo A. Bis-alkylamine quindolone derivatives as new antimalarial leads. Bioorg Med Chem Lett. 2010, 20: 5634–5637. (IF = 2.650).

Lavrado J, Moreira R, Paulo A. Indoloquinolines as scaffolds for drug discovery. Curr Med Chem. 2010, 17: 2348-2370. (IF = 4. 708).

Lavrado J, Reszkab AP, Moreira R, Paulo A, Neidle S. C-11 diamino cryptolepine derivatives NSC748392, NSC748393 and NSC748394: anticancer profile and G-quadruplex stabilization. Bioorg Med Chem Lett. 2010, 20: 7042-7045. (IF = 2. 650).

Lourenço NMT, Monteiro CM, Afonso CAM. Ionic Acylating Agents for Enzymatic Resolution of sec-Alcohols in Ionic Liquids. Eur J Org Chem. 2010, 6938-6943. (IF = 3.096).

Marco-Contelles J, Gómez-Sánchez E, Samadi A, Soriano E, Valderas C, Alvarez-Pérez M, Carreiras MC. Synthesis of new 7-azabicyclo[2.2.1]heptane derivatives. Arkivoc. 2010, 56-73. (IF = 1.377).

Martins TM, Gonçalves LMD, Capela R, Moreira R, do Rosário VE, Domingos A. Effect of synthesized inhibitors on Babesipain-1, a New Cysteine protease from the bovine piroplasm Babesia bigemina. Transbound Emerg Dis. 2010, 57: 68-69. (IF = 1.854).

Matos J, Vale N, Collins MS, Gut J, Rosenthal PJ, Cushion MT, Moreira R, Gomes P. Primacenes: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity. Med Chem Commun. 2010, 1: 199-201.

Monteiro CM, Lourenço NMT, Afonso CAM. Separation of secondary alcohols via enzymatic kinetic resolution using fatty esters as reusable acylating agents. Tetrahedron: Asymmetr. 2010, 21: 952-956. (IF = 2.625).

Mulchande J, Oliveira R, Carrasco M, Gouveia L, Guedes RC, Iley J, R. Moreira. 4-Oxo-b-lactams (azetidine-2,4-diones) are potent inhibitors of human leukocyte elastase. J Med Chem. 2010, 53: 241-253. (IF = 4.802).

Newton AS, Gonçalves LM, Glória PMC, dos Santos DJVA, Moreira R, Guedes RC, Santos MMM. Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study. Eur J Med Chem. 2010, 45: 3858-3863. (IF = 3. 269).

Petrovski Z, Martins BMR, Afonso CAM. Short synthesis of methylenecyclopentenones by intermolecular Pauson–Khand reaction of allyl thiourea. Tetrahedron Lett. 2010, 51: 3356–3359. (IF = 2.660).

Pusztai R, Abrantes M, Serly J, Duarte N, Molnar J, Ferreira MJ. Antitumor-promoting activity of lignans: inhibition of human cytomegalovirus IE gene expression. Anticancer Res. 2010, 30: 451-454. (IF = 1.428).

Ramalhete C, Lopes D, Mulhovo S, Molnár J, Rosário VE, Ferreira MJ. New antimalarials with a triterpenic scaffold from Momordica balsamina. Bioorg Med Chem. 2010, 18: 5254-5260. (IF = 2.822).

Reis M, Trinca A, Ferreira MJ, Monsalve-Puello AR, Grácio MA. Toxocara canis: potential activity of natural products against second-stage larvae in vitro and in vivo. Exp Parasitol. 2010, 126: 191-197. (IF = 1.773).

Rijo P, Simões MF, Francisco AP, Rojas R, Gilman RH, Vaisberg AJ, Rodriguez B, Moiteiro C. Antimycobacterial Metabolites from Plectranthus: Royleanone Derivatives against Mycobacterium tuberculosis Strains. Chem Biodivers. 2010, 7: 922-932. (IF = 1.926).

Rodrigues T, Lopes F, Moreira R. Inhibitors of the Mitochondrial Electron Transport Chain and de novo Pyrimidine Biosynthesis as Antimalarials: The Present Status. Curr Med Chem. 2010, 17: 929-956. (IF = 4.708).

Rosa JN, Reddy RS, Candeias NR, Cal PMSD, Gois PMP. NHC-Iron-Catalyzed Aerobic Oxidative Aromatic Esterification of Aldehydes using Boronic Acids. Org Lett. 2010, 12: 2686–2689. (IF = 5.425).

Santos MMM, Faria N, Iley J, Coles SJ, Hursthouse MB, Martins ML, Moreira R. Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3-d]isoxazole-4,9-diones. Bioorg Med Chem Lett. 2010, 20: 193-195. (IF = 2. 650)

Silva D, Samadi A, Chioua M, Carreiras MC, Marco-Contelles J. The Sandmeyer reaction on some selected heterocyclic ring systems: Synthesis of useful 2-chloroheterocyclis-3-carbonitrile intermediates. Synthesis. 2010, 16: 2725-2730 (IF = 2.572).

Silva DB, Samadi A, Infantes L, Carreiras MC, Marco-Contelles J. Synthesis of (E)-diethyl 6,6’-(diazene-1,2-diyl)bis(5-cyano-2-methyl-4-phenylnicotinates), a new type of 2,2’-azopyridine dyes. Tetrahedron Lett. 2010, 51: 6278-6281. (IF = 2.660).

Simões MF, Rijo P, Duarte A, Barbosa D, Matias D, Delgado J, Cirilo N, Rodríguez B. Two new diterpenoids from Plectranthus species. Phytochem Lett. 2010, 3: 221–225. (IF = 0.957).

Simões MF, Rijo P, Duarte A, Matias D, Rodríguez B. An easy and stereoselective rearrangement of an abietane diterpenoid into a bioactive microstegiol derivative. Phytochem Lett. 2010, 3: 234–237. (IF = 0.957).

Trindade AF, André V, Duarte MT, Veiros LF, Gois PMP, Afonso CAM. Selective arylation of aldehydes with dirhodium(II)-NHC catalysts. Tetrahedron. 2010, 66: 8494-8502. (IF = 3.219).

Wesolowska O, Wisniewski J, Bielawska-Pohl A, Paprocka M, Duarte N, Ferreira MJ, Dus D, Michalak K. Stilbenes as multidrug resistance modulators and apoptosis inducers in human adenocarcinoma cells. Anticancer Res. 2010, 30:4587-4593. (IF = 1.428).

Books and book chapters

Marco L, Carreiras MC. Galantamine, a natural product for the treatment of Alzheimer`s disease. In: Frontiers in CNS Drug Discovery. Atta-ur-Rahman, Iqbal Choudary MI (Eds), Bentham, 2010. Bentham online Book series: eISBN: 978-1-60805-159-5. DOI: 10.2174/97816080515951100101.

 

Amat M, Gómez-Esqué A, Escolano C, Santos MMM, Molins E, Bosch J. Enantioselective Formal Synthesis of (+)-Dihydrocorynantheine and (─)-Dihydrocorynantheol, J Org Chem. 2009, 74: 1205-1211. (IF = 4.219).

Candeias NR, Branco LC, Gois PMP, Afonso CAM, Trindade AF. More Sustainable Approaches for the Synthesis of N-Based Heterocycles. Chem Rev. 2009, 109: 2703-2902. (IF = 35.957).

Candeias NR, Veiros LF, Afonso CAM, Gois PMP. Water: A Suitable Medium for the Petasis Borono-Mannich Reaction. Eur J Org Chem. 2009: 1859-1863. (IF = 3.096).

Capela R, Oliveira R, Gonçalves LM, Domingos A, Gut J, Rosenthal PJ, Lopes F, Moreira R. Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition. Bioorg Med Chem Lett. 2009, 19: 3229-3232. (IF = 2.650).

Coutinho I, Pereira G, Simões MF, Côrte-Real M, Gonçalves J, Saraiva L. Selective activation of protein kinase C-δ and – by 6,11,12,14-tetrahydroxy-abieta-5,8,11,13-tetraene-7-one (coleon U).  Biochem Pharmacol. 2009, 78: 449-459. (IF = 4.254).

Duarte N, Ramalhete C, Varga A, Molnár J, Ferreira MJU. Multidrug Resistance Modulation and Apoptosis Induction of Cancer Cells by Terpenic Compounds Isolated From Euphorbia Species. Anticancer Res. 2009, 29: 4467-4472. (IF = 1.428).

Erdtman, E, dos Santos, DJVA, Löfgren, L, Eriksson, LA. Erratum to ‘Modelling the behavior of 5-aminolevulinic acid and its alkyl esters in a lipid bilayer’ [Chem. Phys. Lett. 463 (2008) 178]. Chem Phys Lett. 2009, 470: 369-369. (IF = 2.291).

Eriksson, ESE, dos Santos, DJVA, Guedes, RC, Eriksson, LA. Properties and permeability of hypericin and brominated hypericin in lipid membranes. J Chem Theor Comp. 2009, 5:3139-3149. (IF = 4.804).

Faustino CMC, Calado ART, Garcia-Rio L. Gemini Surfactant-Protein Interactions: Effect of pH, Temperature and Surfactant Stereochemistry. Biomacromolecules 2009;10(9):2508-2514.

Faustino CMC, Calado ART, Garcia-Rio L. New Urea-based Surfactants Derived from α,ω-Amino Acids. J Phys Chem B 2009;113(4):977-982.

Fernandes I, Vale N, Freitas V, Moreira R, Mateus N, Gomes P. Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine. Bioorg Med Chem Lett. 2009, 19:6914-6917. (IF = 2.650).

Gomes LFR, Trindade AF, Candeias NR, Veiros LF, Gois PMP, Afonso CAM. Cyclization of Diazoacetamides Catalyzed by N-Heterocyclic Carbene Dirhodium(II) Complexes. Synthesis-Stuttgart. 2009, 20:3519-3526. IF = 2.572).

Leroy, F, dos Santos, DJVA, Müller-Plathe, F. Interfacial excess free energies of solid-liquid interfaces by molecular dynamics simulation and thermodynamic integration.  Macromol Rapid Comm. 2009, 30: 864–870. (IF = 4.263).

Mansoor TA, Ramalhete C, Molnár J, Mulhovo S, Ferreira MJU. Tabernines A-C, beta-carbolines from the leaves of Tabernaemontana elegans. J Nat Prod. 2009, 72: 1147-1150. (IF = 3.159).

Mansoor TA, Ramalho RM, Mulhovo S, Rodrigues CMP, Ferreira MJU. Induction of apoptosis in HuH-7 cancer cells by monoterpene and beta-carboline indole alkaloids isolated from the leaves of Tabernaemontana elegans. Bioorg Med Chem Lett. 2009, 19: 4255-4258. (IF = 2.650).

Marco-Contelles J, Léon R, de los Ríos C, Samadi A, Bartolini M, Andrisano V, Huertas O, Barril X, Luque FJ, Rodríguez-Franco MI, López B, López MG, García AG, Carreiras MD, Villarroya M. Tacripyrines, the first tacrine-dihydropyridine hybrids, as multi-target-directed ligands for the treatment of Alzheimer`s disease. J Med Chem. 2009, 52: 2724-32. (IF = 4.802).

Marco-Contelles J, Pérez-Mayoral E, Samadi A, Carreiras MD, Soriano E. Recent Advances in the Friedländer Reaction. Chem Rev. 2009, 109: 2652-2671. (IF = 35.957).

Maria Bocheńska, Peter J. Cragg, Marcin Guziński, Artur Jasiński, Joanna Kulesza, Paula M. Marcos, Radosław Pomećko, “Ion-Selective Electrodes Based on p-tert-Butyl-homooxacalixarene di(ethyl)amides”, Supramol. Chem. 2009, 21 (8),732-737.

Martins C, Eleutério A, Carreiras MC, Samadi A, Soriano E, Léon R, Marco-Contelles J. A reinvestigation of the acid-promoted heterocyclization of 2-(2-oxo-2-arylethyl)malononitriles in the presence of amines. Mol Divers. 2009, 13: 459-68.(IF = 2.071).

Moreira R. The Portuguese Chemical Society. One century of history, on the way to the future. Med Chem Watch. 2009, 6: 6.

Paula M. Marcos, José R. Ascenso, “Synthesis, Structural Characterisation and Metal Ion Binding Properties of a New p-tert-Butyldihomooxacalix[4]-crown-6”, Supramol. Chem. 2009, 21 (1-2), 61-67.

Paula M. Marcos, José R. Ascenso, Manuel A. P. Segurado, Raul J. Bernardino, Peter J. Cragg, “Synthesis, Binding Properties and Theoretical Studies of p-tert-Butylhexahomotrioxacalix[3]arene Tri(adamantyl)ketone with Alkali, Alkaline Earth, Transition, Heavy Metal and Lanthanide Cations”, Tetrahedron 2009, 65 (2), 496-503.

Perry MJ, Mendes E, Simplício AL, Coelho A, Soares R V, Iley J, Moreira R, Francisco AP. Dopamine- and tyramine-based derivatives of triazenes: activation by tyrosinase and implications for prodrug design. Eur J Med Chem, 2009, 44: 3228-3234. (IF = 3.269).

Ramalhete C, Mansoor TA, Mulhovo S, Molnár J, Ferreira MJU. Cucurbitane-type Triterpenoids from the African Plant Momordica balsamina. J Nat Prod. 2009, 72: 2009-2013. (IF = 2.843).

Ramalhete C, Molnár J, Mulhovo S, Rosário VE, Ferreira MJU. New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells. Bioorg Med Chem. 2009, 17: 6942-6951. (IF = 2.822).

Rijo P, Simões MF, Duarte A, Rodríguez B. Isopimarane diterpenoids from Aeollanthus rydingianus and their antimicrobial activity. Phytochemistry. 2009, 70: 1161-1165. (IF = 3.104).

Rodrigues T, Guedes RC, Santos DJVA, Gut J, Rosenthal PJ, Moreira R, Lopes F. Design, synthesis and Structure Activity-Relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials. Bioorg Med Chem Lett. 2009, 19: 3476-3480. (IF = 2.531).

Rodrigues T, Moreira R, Dacunha-Marinho B, Lopes F. Bis{(E)-3-[(diethylmethylammonio)methyl]-N-[3-(N,N-dimethylsulfamoyl)-1-methylpyridin-4-ylidene]-4-methoxyanilinium} tetraiodide pentahydrate. Acta Crystallogr E. 2009, 65: O283-U1828. (IF = 0.367).

Santos CR, Capela R, Pereira CSGP, Valente E, Gouveia L, Pannecouque C, De Clercq E, Moreira R, Gomes P. Structure-activity relationships for dipeptide prodrugs of acyclovir: implications for prodrug design. Eur J Med Chem. 2009, 44: 2339-2346. (IF = 3.269).

Santos DM, Santos MMM, Viana RJS, Castro RE, Moreira R,Rodrigues CMR. Naphtho[2,3-d]isoxazole-4,9-dione-3-carboxylates: potent, non-cytotoxic, anti-apoptotic agents. Chem-Biol Interact. 2009, 180: 175-182. (IF = 2.457).

Simões MF, Valente E, Gomez MJR, Anes E, Constantino L. Lipophilic POA Amide and Ester Prodrugs. Stability, Activation and activity against M. tuberculosis. Eur J Pharm Sci. 2009, 37: 257-263. (IF= 2.608).

Spengler G, Ramalhete C, Martins M, Martins A, Serly J, Viveiros M, Molnár J, Duarte N, Mulhovo S, Ferreira MJU, Amaral L. Evaluation of cucurbitane-type triterpenoids from Momordica balsamina on P-glycoprotein (ABCB1) by flow cytometry and real-time fluorometry. Anticancer Res. 2009, 29: 3989-3993. (IF = 1.428).

Teisseyre A, Duarte N, Ferreira MJU, Michalak K. Influence of the multidrug transporter inhibitors on the activity of kv1.3 voltage-gated potassium channels. J Physiol Pharmacol. 2009, 60: 69-76. (IF = 1.489).

Trindade AF, Gois PMP, Afonso CAM. Recyclable Stereoselective Catalysts. Chem Rev. 2009, 109: 418–514. (IF = 35.957).

Vale FF, Mégraud F, Vítor JMB. Geographic distribution of methyltransferases of Helicobacter pylori: evidence of human host population isolation and migration. BMC Microbiol. 2009, 9: 193. (IF = 2.890).

Vale N, Matos J, Moreira R, Gomes P. Electrospray ionization mass spectrometry as a valuable tool in the characterization of novel primaquine peptidomimetic derivatives. Eur J Mass Spectrom. 2009,15:627-640. (IF = 1.340).

Vale N, Moreira R, Gomes P. Primaquine revisited six decades after its discovery. Eur J Med Chem. 2009, 44: 937-953. (IF = 3.269).

Vale N, Nogueira F, do Rosário VE, Gomes P, Moreira R. Primaquine dipeptide derivatives bearing an imidazolidin-4-one moiety at the N-terminus as potential antimalarial prodrugs. Eur J Med Chem. 2009, 44: 2506-2516. (IF = 3.269).

Vale N, Prudêncio M, Marques CA, Collins MS, Gut J, Nogueira F, Matos J, Rosenthal PJ, Cushion MT, do Rosário VE, Mota MM, Moreira R, Gomes P. Imidazoquines as antimalarial and anti-pneumocystis agents. J. Med. Chem. 2009, 52: 7800-7807. (IF = 4.802).

 

Abrantes M, Mil-Homens T, Duarte N, Lopes D, Cravo P, Madureira MC, Ferreira MJU.Antiplasmodial Activity of Lignans and Extracts from Pycnanthus angolensis. Planta Med., 2008, 74: 1408-1412. IF = 1.848

André V, Duarte MTD, Trindade AF, Gois PMP, Afonso CAM. Tetra-μ-acetato-bis{[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]rhodium(II)}(Rh—Rh) tetrahydrofurantetrasolvate. Acta Cryst. 2008, C64: m345–m348. IF = 0.719

Candeias NR, Gois PMP, Afonso CAM. C-H Carbene Insertion of α-Diazo Acetamides by Photolysis in Non-Conventional Media. J. Org. Chem.  2008, 73: 5926-5932. IF = 3.959

dos Santos DJVA, Müller-Plathe F, Weiss V. Consistency of ion adsorption and excess surface tension in molecular dynamics simulations of aqueous salt solutions. J. Phys. Chem. C, 2008, in press.

dos Santos, DJVA, Newton, AS, Bernardino, R, Guedes, RC. Substituent effects on O-H and S-H bond dissociation enthalpies of disubstituted phenols and thiophenols. Int. J. Quantum Chem., 2008, 108: 754-761. IF= 1.368

Duarte N, Járdánházy A, Hilgeroth A, Molnár J, Ferreira MJU. Synergistic interaction between p-glycoprotein modulators and epirubicin on resistant cancer cells. Bioorg. Med. Chem., 2008, 16: 9323-9330. IF = 2.662.

Duarte N, Kayser O, Abreu P, Ferreira MJU. Antileishmanial activity of Piceatannol isolated from Euphorbia lagascae seeds. Phytother. Res. 2008, 22: 455-457. IF = 1.430

Duarte N, Lage H, Ferreira MJU. Three new jatrophane polyesters and antiproliferative constituents from Euphorbia tuckeyana. Planta Med., 2008, 74: 61-68. IF = 1.848

Erdtman E, dos Santos DJVA, Löfgren L, Eriksson LA. Modelling the behavior of 5-aminolevulinic acid and its alkyl esters in a lipid bilayer. Chem. Phys. Lett., 2008, 463: 178-182. IF= 2.207

Eriksson, ESE, Guedes, RC, Eriksson, LA. Redox and debromination reactions of brominated hypericin. Int. J. Quantum Chem., 2008, 108: 1921-1929. IF= 1.368

Esposito O, Gois PMP, Lewis AKK, Caddick S, Cloke FGN, Hitchcock PB. Alkylpalladium N-Heterocyclic Carbene Complexes, Synthesis, Reactivity and Catalytic Properties. Organometallics 2008, 27: 6411-6418. IF = 3.833

Gaspar-Marques C, Simões MF, Valdeira ML, Rodríguez B. Terpenoids and phenolics from Plectranthus strigosus, bioactivity screening. Nat Prod Research, 2008, 22: 167–177. IF=0.683

Gomes LFR, Trindade AF, Candeias NR, Gois PMP, Afonso CAM. Intramolecular C-H Insertion using NHC-Di-Rhodium(II) Complexes: The Influence of Axial Coordination Tet. Lett 2008, 49: 7372-7375. IF = 2.615

Lavrado J, Paulo A, Gut J, Rosenthal PJ, Moreira R. Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity and cytotoxicity. Bioorg. Med. Chem. Lett., 2008, 18: 1378-1381. IF = 2.604.

Martinelli A, Moreira R, Cravo PVL. Malaria Combination Therapies: Advantages and Shortcomings. Mini-Rev. Med. Chem., 2008, 8: 201-212. IF = 3.060.

Mulchande J, Guedes RC, Tsang W-Y, Page MI, Moreira R, Iley J. Azetidine-2,4-diones (4-oxo-b-lactams) as scaffolds for designing elastase inhibitors. J. Med. Chem., 2008, 51: 1783-1790. IF = 4.895.

Paulo A, Martins S, Branco P, Dias T, Borges C, Rodrigues AI, Costa MC, Teixeira A, Mota-Filipe H. The opposing effects of the flavonoids isoquercitrin and sissotrin, isolated from Pterospartum tridentatum, on oral glucose tolerance in rats. Phytother. Res. 2008; 22: 539-543. IF=1.430

Peihua, G, Constantino, L, Zhang Y. Enhancement of the antituberculosis activity of weak acids by inhibitors of energy metabolism but not by anaerobiosis suggests that weak acids act differently from the front-line tuberculosis drug pyrazinamide. J. Med. Microbiol. 2008, 57: 1129-1134 IF= 2.091

Ribeiro IA, Ribeiro MHL. Kinetic modelling of naringin hydrolysis using a bitter sweet alfa-rhamnopyranosidase immobilized in k-carrageenan. J Mol Catal B Enzym. 2008; 51: 10-18.

Ribeiro IA, Ribeiro MHL. Naringin and naringenin determination and control in grapefruit juice by a validated HPLC method. Food Control. 2008; 19: 432-438.

Ribeiro IA, Rocha J, Sepodes B, Mota-Filipe H, Ribeiro MHL. Effect of naringin enzymatic hydrolysis towards naringenin on the anti-inflammatory activity of both compounds. J Mol Catal B Enzym. 2008; 52-53: 13-18.

Rodrigues T, Moreira R, Guedes R, Lopes F. Unanticipated acyloxymethylation of sumatriptan indole nitrogen atom and its implications in prodrug design. Arch. Pharm., 2008, 341: 344-350. IF = 1.300.

Santos C, Morais J, Gouveia L, De Clercq E, Pannecouque C, Nielsen CU, Steffansen B, Moreira R, Gomes P. Dipeptide derivatives of AZT: synthesis, chemical stability, activation in human plasma, hPEPT1 affinity and antiviral activity. ChemMedChem, 2008, 3: 970-978. IF = 2.825.

Serrano R, Ferreira P, Gomes ET, Silva O, The Use of SEM and Light Microscopy for the Characterization of Hypericum foliosum Aerial Part as a Medicinal Plant. Microsc. Microanal. 2008, 14: 107-108. IF=2.108

Silva O, Serrano R, Gomes ET, Botanical Characterization of Guiera senegalensis Leaves, Microsc. Microanal. 2008, 14: 398–404. IF=2.108

Vale F, Encarnação P, Vítor J. A new algorithm for cluster analysis of genomic methylation: the Helicobacter pylori case, Bioinformatics, 2008, 24: 383-388. IF = 5.039

Vale F, Matos A, Carvalho P, Vítor J, Helicobacter pylori phage screening, Microsc. Microanal. 2008, 14:150-151. IF=2.108

Vale N, Collins MS, Gut J, Ferraz R, Rosenthal PJ, Cushion MT, Moreira R, Gomes P. Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones. Bioorg. Med. Chem. Lett., 2008, 18: 485-488. IF = 2.604.

Vale N, Matos J, Gut J, Nogueira F, do Rosário V, Rosenthal PJ, Moreira R, Gomes P. Imidazolidin-4-one peptidomimetic derivatives of primaquine: synthesis and antimalarial activity. Bioorg. Med. Chem. Lett., 2008, 18, 4150-4153. IF = 2.604.

Vale N, Matos J, Moreira R, Gomes P. Amino acids as selective acylating agents: regiosselective N1-acylation of imidazolidin-4-one derivatives of the antimalarial drug primaquine. Tetrahedron, 2008, 64: 11144–11149. IF = 2.869.

Vale N, Matos J,Moreira R, Gomes P. Electrospray ionization-ion trap mass spectrometry study of PQAAPro and PQProAA mimetic derivatives of the antimalarial primaquine. J Am Soc Mass Spectrom, 2008, 19:1476-1490. IF = 3.664.

Vale N, Moreira R, Gomes P. Characterization of primaquine imidazolidin-4-ones with antimalarial activity by electrospray ionization ion trap mass spectrometry. Int. J. Mass Spect., 2008, 270: 81-93. IF = 2.411.

Books / Book Chapters

Francisco AP, Perry MJ, Moreira R, Mendes E. Chapter 9: Alkylating Agents. In: Missailidis S. (ed.), Anticancer Therapeutics, John Wiley and Sons, 2008, 133-158. ISBN/ISSN: 0470723033