The ProteinConjugates is an innovative science & training program that aims to develop new site-selective bioconjugation methodologies that explore natural proteinogenic amino acids and their use to build protein conjugates for the treatment of serious conditions such as cancer or reumathoid arthritis, by providing advanced training to the next generation of excellent European researchers.
Major goal of the project include:
The development of innovative and highly efficient site-selective protein modification reactions.
Validation of new targeting antibodies and protein-based nanoparticle scaffolds for active targeted drug delivery.
The construction, characterization and biological evaluation of chemically defined therapeutically useful protein conjugates.
The translation of novel tools and conjugates into novel anti-cancer therapeutics with improved selectivity, safety and efficacy.
ProteinConjugates is an inter- and multi-disciplinary network for the education of talented young scientists who will learn how to rationally design and construct the next generation of chemically-defined and innovative protein drug-conjugates. A well devised complementary interaction between academy and pharmaceutical industry is at the centre of such a network, which involves 8 academic groups and 2 leading European industrial partner organizations that will host secondments while providing training.
Academic Participants: Dr. Gonçalo Bernardes (IMM, Portugal), Dr. Pedro Gois (FF, Portugal), Prof. Stephen Caddick (UCL, UK), Prof. Tanja Weil (Ulm Uni., Germany), Dr. Francisco Corzana (Uni. De la Rioja), R. Tuomas Knowles (Uni. Cambridge, UK), Dr. Ludger Johannes (Institute Curie, France), Prof. Christian Becker (Uni. Vienne, Austria).
Industrial Participants: Carmen Cuevas (PharmaMar, SA), Dr. Willian Heggie (Hovione SA, Portugal).
Members of the International Advisory Board
Dr Peter Senter - VP Chemistry, Seattle Genetics, United States.
Prof Luisa De Cola - Institut de Science et d'Ingénierie Supramoléculaires, France.
Prof Derek Tan - Memorial Sloan–Kettering Cancer Center, United States.
Prof Dario Neri - Department of Chemistry and Applied Biosciences, ETH, Switzerland.
ProteinConjugates a European Training Network