SELECTED PAPERS IN PEER-REVIEWED JOURNALS
• Woischnig A-K, Gonçalves LM, Ferreira M, Kuehla K, Kikhney J, Moter A, Ribeiro IAC, Almeida AJ, Khanna N, Bettencourt A (2018). Daptomycin-loaded acrylic microparticles increase intracellular and anti-biofilm activity against Staphylococcus aureus. Int J of Pharm, 550 (1-2), 372-379.
• Silva T, Silva JC, Colaço B, Gama A, Araújo M, Fernandes MH, Bettencourt A, Gomes P (2018). Tissue response and antibacterial efficacy of PMMA-loaded minocycline bone cements in a translational experimental animal model. J. of Biomaterials Applications, DOI: 10.1177/0885328218795290.
• Hernandez JF, Ribeiro IAC, Martin V, Martija OL, Zuza E, Bettencourt AF, Sarasua JR (2018). Release mechanisms of urinary tract antibiotics when mixed with bioabsorbable polyesters. Mater Sci Eng C Mater Biol Appl, 93:529-538.
• Ferreira M, Bettencourt A, Gaspar M (2018). Lipid-based nanosystems as drug delivery carriers for specific targeting of bone infections: current approaches and future endeavours. Expert Opinion on Drug Delivery (accepted).
• Marques CF, Olhero SM, Torres PMC, Abrantes JCC, Fateixa S, Nogueira HIS, Ribeiro IAC, Bettencourt A, Sousa A, Granja P, Ferreira JMF (2019). Novel sintering-free scaffolds obtained by additive manufacturing for concurrent bone regeneration and drug delivery: Proof of concept. Mater Sci Eng C Mater Biol Appl, C94, 426-436.
• Santos-Ferreira I, Bettencourt A, Gonçalves LM, Kasper S, Bétrisey B, Kikhney J, Moter A, Trampuz A, Almeida AJ. Activity of Daptomycin and Vancomycin-loaded poly-epsilon-caprolactone microparticles against mature staphylococcal biofilms. Int J Nanomedicine (2015) vol 15, pages 4351- 4351-4366.
• Martin V, Bettencourt A (2018). Bone regeneration: biomaterials as local delivery systems with improved osteoinductive properties. Mat Sci Eng 82:363-371.
• Silva T, Grenho L, Barros J, Silva JC, Pinto R, Matos A, Colaço B, Fernandes MH, Bettencourt A, Gomes P (2017). Minocycline-releasing PMMA system as a space maintainer for staged bone reconstructions – in vitro antibacterial, cytocompatibility and anti-inflammatory characterization. Biomed Mater, 6;12(3):035009.
• Graça D, Louro H, Santos J, Dias K, Gonçalves LM, Almeida AJ, Silva MJ, Bettencourt A (2017). Toxicity screening of novel poly(methylmethacrylate)-Eudragit nanocarriers on L929 fibroblast cells. Tox Letters, 276:129-137.
• Ferreira M, Rzhepishevska O, Grenho L, Malheiros D, Gonçalves L, Almeida AJ, Jordão L, Ribeiro IA, Ramstedt M, Gomes P, Bettencourt A (2017). Levofloxacin-loaded bone cement delivery system: Highly effective against intracellular bacteria and Staphylococcus aureus biofilms. Int J Pharm, 30;532(1):241-248.
• Matos A, Ribeiro I, Guedes R, Pinto R, Vaz M, Gonçalves L, Almeida AJ, Bettencourt A. Key-properties Outlook of a levofloxacin-loaded acrylic bone cement with improved antibiotic delivery. Int. J. of Pharm. (2015) 15;485(1-2):317-28. doi: 10.1016/j.ijpharm.2015.03.035.
• Ferreira IFS, Bettencourt A, Betrisey B, Gonçalves LM, Trampuz A, Almeida AJ. Improvement of the Antibacterial Activity of Daptomycin-loaded Polymeric Microparticles by Eudragit RL 100: an Assessment by Isothermal Microcalorimetry. Int. J. of Pharm. 485 (2015) 171–182. 2015. doi:10.1016/j.ijpharm.2015.03.016
• Matos AC, Marques CF, Pinto RV, Ribeiro IA, Gonçalves LM, Vaz MA, Ferreira JM, Almeida AJ, Bettencourt AF. Novel doped calcium phosphate-PMMA bone cement composites as levofloxacin delivery systems. Int J Pharm. (2015) 25;490(1-2):200-8. doi: 10.1016/j.ijpharm.2015.05.038.
• Matos A, Gonçalves L, Rijo P, Vaz M, Almeida AJ, Bettencourt A. A Novel Modified Acrylic Bone Cement Matrix. A Step Forward On Antibiotic Delivery Against Multiresistant Bacteria Responsible For Prosthetic Joint Infections. Mat Sci & Engineer C, 2014;38(1):218–226.
• Neves B, Lopes L, Miranda J, Castro M, Bettencourt A. Ethanol post-polymerization treatment for improving the biocompatibility of acrylic relin resins. Biomed Res International. Vol 2013 (2013), article ID 485246.
• Vilhena C, Bettencourt A. Daptomycin: A Review of Properties, Clinical Use, Drug Delivery and Resistance. MiniReviews in Medicinal Chemistry, 2012, 12 (3), 202-209.
• Bettencourt A, Almeida AJ. "Poly (methyl methacrylate) Particulate Carriers in Drug Delivery". J Microencapsul 2012; 29(4): 353–367.
• Bettencourt A, Florindo HF, Ferreira IFS, Matos A, Monteiro J, Neves C, Lopes P, Castro M, Almeida AJ. Incorporation of Tocopherol Acetate-containing Particles in Acrylic Bone Cement. J Microencapsul, 2010;27(6):91-101.
• Bettencourt A, Calado A, Amaral J, Vale FM, Rico JMT, Monteiro J, Lopes A, Pereira L, Castro M (2000). In vitro release studies of methylmethacrylate liberation from acrylic cement powder. Int J Pharm, 197:161-168.
• Bettencourt A, Calado A, Amaral J, Vale FM, Rico JMT, Monteiro J, Castro M (2001). The influence of vacuum mixing on methylmethacrylate liberation from acrylic cement powder. Int J Pharm, 219: 89-93.
• Bettencourt A, Calado A, Amaral J, Vale FM, Rico JMT, Monteiro J, Montemor MF, Ferreira MGS, Castro M (2002). The effect of ethanol on acrylic bone cement. Int J Pharm, 241:97-102.
• Bettencourt A, Calado ART, Amaral J, Vale F, Toscano Rico J M, Monteiro J, Montemor MF, Ferreira MGS, Castro M (2004). Surface studies on acrylic bone cements. Int J Pharm, 278:181-186.
Other publications available at
Researcher ID,
ORCID and
Scopus.
BOOK CHAPTERS
• Martin V, Bettencourt A (2018). Bone regeneration: biomaterials as local delivery systems with improved osteoinductive properties. In: Shiffan RA (ed). Bone regeneration. Springer (by invitation, submitted).
• Bettencourt A., Almeida AJ. Poly(methyl methacrylate): Drug Delivery Applications. Mishra MK (ed.), “Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, CRC Press, Taylor and Francis, ISBN1-13: 9781439898796) (2015).
• Louro H., Bettencourt A., Gonçalves LM, Almeida AJ, Silva MJ. Role of nanogenotoxicology studies in safety evaluation of nanomaterials. S. Thomas, Y. Grohens, N. Ninan: Nanotechnology Applications for Tissue Engineering. ISBN: 978-0-323-32889-0. 2015 Elsevier Inc. DOI: http://dx.doi.org/10.1016/B978-0-323-32889-0.00016-9 (2015).
PATENT
Rodrigues MA, Padrela L, Matos HA, Azevedo EG, Pinheiro L, Bettencourt A, Castro M, Almeida AJ, Duarte A (2013). Crystalline minocycline thermo-resistant minocycline obtained by recrystallization with carbon dioxide. Patente Portuguesa nº 106063. Concedida em 25/05/2017.